刘 颖

  • 电子邮箱:liu_ying@fudan.edu.cn

  • 办公地点:复旦大学枫林校区东1号楼214室

  • 电话:021-54237528-2142

  • 研究方向

  • 学术任职

  • 学术报告

  • 重要学术贡献

  • 科研成果

  • 方向一 胶质瘤血管新生

  • 方向二 胶质瘤代谢与肿瘤增殖

  • 2016-09 至今 上海市医学会病理专科分会第十届青年委员会委员

  • 2017-05 至今 中国研究型医院学会超微与分子病理学专业委员会神经系统疾病多学科诊断学组委员

  • 2018-01 至今 中华医学会病理学分会神经病理学组委员

  • 2018-10 至今 中华医学会病理教学委员会秘书

  • Liu Xueguang, Renal Pathology of Nephrotic Syndrome in Chinese Children, 13th 2015 Korea-China -Japan Pediatric Nephrology Seminar 2015, Seoul, South Korea, 9-10 May 2015

教学方面:研究生《现代组织化学》、《分子病理学》、《基础科研病理学》课程负责人,病理系及学院多项本科生课程教学;指导多名本科生科创及毕业课题;担任临床八年制,基础医学医学素养培训导师。主编研究生教材《现代组织化学原理及技术》;参编系《病理学》教材。

科研方面:主持国家自然基金面上项目3项,上海市自然基金1项;参加了973重大项目,国家自然基金重点项目,上海市重点项目等。

主要研究方向为肿瘤分子病理,先后发表30余篇科研论文,以第一作者或通讯作者发表SCI论文15篇,包括 Nature communications, JCI, JNEN, Cancer Cell, Oncogene, J Neuro-oncology, Acta Neuropathologica等。

发表论文:

  • Chenyue Xu, Luning Mao, Ji Xiong, Jianbo Wen, Yin Wang, Daoying Geng, Ying Liu*. TAZ Expression on Endothelial Cells Is Closely Related to Blood Vascular Density and VEGFR2 Expression in Astrocytomas. J Neuropathol Exp Neurol,2019 Feb 1;78(2):172-180

  • Xu YP(co-first author), Lv L(co-first author), Liu Y(co-first author), Smith MD, Li WC, Tan XM, Cheng M, Li Z, Bovino M, Aubé J, Xiong Y.Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy. J Clin Invest. 2019 Jul 16;130. pii: 129317. doi: 10.1172/JCI129317.

  • Yuan Liu(co-first author), Ji-Zheng Guo(co-first author), Ying Liu(co-first author), Kui Wang, Wencheng Ding, Hui Wang, Xiang Liu , Shengtao Zhou, Xiao-Chen Lu, Hong-Bin Yang, Chenyue Xu , Wei Gao , Li Zhou, Yi-Ping Wang , Weiguo Hu, Yuquan Wei, Canhua Huang, Qun-Ying Lei. Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth. Nat Commun. 2018;9:4429.

  • Ying Liu, Marwan Alahiri, Bianca Ulloa, Boxun Xie, Saud A. Sadiq. Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine-induced blood brain barrier dysfunction via suppression of MLCK signaling pathway. Immun Inflamm Dis. 2018 Mar;6(1):72-80.  doi: 10.1002/iid3.187.

  • Hui Yang (co-first author), Ying Liu(co-first author), Feng Bai, Jing-Ye Zhang, Sheng-Hong Ma, Jing Liu,Zu-De Xu, Hong-Guang Zhu, Zhi-Qiang Ling, Dan Ye, Kun-Liang Guan, Yue Xiong. Tumor development is associated with de crease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene, 2013,32,663-669. 被引用335次,高被引文章。

  • 6.Liu Y, Jiang W, Liu J, Zhao S, Xiong J, Mao Y, Wang Y. IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma. J Neurooncol. 2012 Sep;109(2):253-60.

  • Jia Z, Geng D, Xie T, Zhang J, Liu Y(corresponding author). Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging. J Clin Neurosci 2012;19(6):820-823.

  • Ke Rong-Hu, Xiong Ji, Liu Ying *(corresponding author). Adenosine A2a   receptor induces GDNF expression by Stat3 signal in vitro. Neuroreport. 2012 Nov 14;23(16):958-62.

  • Wei Xu(co-first author), Hui Yang(co-first author),Ying Liu (co-first author),Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang,  Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu, Qun-ying Lei, Kun-Liang Guan, Shi-min Zhao, Yue Xiong. Oncometabolite 2-Hydroxyglutarate is a Competitive Inhibitorof a-Ketoglutarate-Dependent Dioxygenases. Cancer Cell. 2011,19: 17–30. 被引用 1393次,是高被引文章。

  • Ying Liu, Maya Mimuro, Mari Yoshida, Yoshio Hashizume, Hisayoshi Niwa, Shinichi Miyao, Nobuko Ujihira,Hiroyasu Akatsu. Inclusion-positive cell types in adult-onset intranuclear inclusion body disease: implications for clinical diagnosis. Acta Neuropathologica, 2008; 116: 615-623.

专著:

  • 刘颖,朱虹光。现代组织化学原理及技术。 第三版,上海,复旦大学出版社,2017年。

  • 张志刚,刘颖。病理学实验教程。第一版,复旦大学出版社,2012年。