研究方向
学术任职
学术报告
重要学术贡献
荣誉与获奖
科研成果
多能干细胞与心血管疾病的病理生理学
心血管疾病的药物筛选与转化
器官间对话的分子机制与中西医结合研究
国内外：
2015-今 中国病理生理学会 理事
2013-今 中国生理学会 理事
2013-今 中国微循环学会 理事
2014-今 上海市病理生理学会 理事
Ning Sun, RNA-binding protein QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function, ISHR 2019 Conference, Beijing China, June 26th-29th 2019
Ning Sun,Pluripotent stem cell as a model for dilated cardiomyopathy, AHA 2011, Orlando Florida, USA, November 11th-15th
在斯坦福大学留学期间率先建立了脂肪干细胞重编程为诱导多能干细胞的新方法 (PNAS, 2009, 引用: 610次)。首次建立了人类家族遗传性扩张型心肌病诱导多能干细胞的模型并进行了疾病新机制的研究 (Science Translational Medicine, 2012，引用: 598次)。回国后建立了人类诱导多能干细胞分化来源的心室肌细胞的纯化新技术，制备了可用于移植的人造人类心室肌组织，拓展了生物新材料治疗人类心肌梗塞的应用研究，提出了心外膜补片材料最佳特性的新理论 (Biomaterials 2016；Nature Biomedical Engineering 2019; Acta Biomaterialia 2019)；开拓了家族遗传性心肌病基因治疗的临床前转化研究等（Nature Communications, 2021; Protein Cell, 2020, 2021; JMCC, 2018）。已发表包括Nature Biomedical Engineering, Science Translational Medicine, Nature Methods, Cell Stem Cell, Nature Communications, Biomaterials, Protein Cell等杂志在内的SCI论文50余篇，论文被引用2000余次
2013 入选国家第四批“青年qr计划”
2014 入选国家自然科学基金“优秀青年科学基金”
2017 入选上海市科委“优秀学术带头人计划”
2020年度上海市科学技术奖科技进步奖 一等奖，《免疫性疾病的间充质干细胞关键技术的创新与临床应用》（赵春华、白雪源、吴际、曹翠红、孙宁、陈思锋等）
发表论文：
Chen X#, Liu Y#, Xu C#, Ba L, Liu Z, Sheng W, Huang G*, Shou W*, Sun N*. RNA-binding protein QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function. Nature Communications, 2021, 12:89. IF=12.121
Li E, Li X, Huang J, Xu C, Liang Q, Ren K, Bai A, Lu C*, Qian R*, Sun N*. BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy. Protein Cell, 2020, 11(9):661-679. IF=10.164
Yufan Zheng#, Baiping Cui#, Wenrui Sun, Sining Wang, Xu Huang, Han Gao, Fei Gao, Yanpeng An, Xiaobo Li*, Ning Sun*. Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury. International Journal of Biological Science, 2020,16(7):1166-79. IF=4.858
Lin X, Liu Y, Bai A, Cai H, Bai Y, Jiang W, Yang H, Wang X, Yang L*, Sun N*, Gao H*. A viscoelastic adhesive epicardial patch for treating myocardial infarction. Nature Biomedical Engineering, 2019, 3(8):632-643. (同行评论) IF=18.952
Cui B, Zheng Y, Sun N*. Repair of Adult Mammalian Heart after Damages by Oral Intake of Gu Ben Pei Yuan San. Frontiers in Physiology, 2019, May 22; 10:607. IF=3.367
Yang H, Wei L, Liu C, Zhong W, Li B, Chen, Han R, Zhuang J, Qu JX, Tao H, Chen H, Wang W*, Sun N*. Engineering Human Ventricular Heart Tissues Based on Macroporous Iron Oxide Scaffolds. Acta Biomaterialia, 2019, 88:540-553. IF=7.242
Zhan Y, Sun X, Li B, Cai H, Xu C, Liang Q, Lu C, Qian R, Chen S, Yin L, Sheng W, Huang G, Sun A*, Ge J*, Sun N*. Establishment of a PRKAG2 Cardiac Syndrome Disease Model and Mechanism Study Using Human Induced Pluripotent Stem Cells. J Mol Cell Cardiol. 2018, 13(117):49-61. IF=4.133
Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G*, Liang P*, Sun N*. Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cells Res Ther, 2017, 8(1):202. IF=5.116
Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N*. Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials, 2016, 105: 52-65 IF=10.317
10.Chao Lu, Yang Yang, Ran Zhao, Bingxuan Hua, Chen Xu, Zuoqin Yan, Ning Sun*, Ruizhe Qian*. Role of Circadian Gene Clock during Differentiation of Mouse Pluripotent Stem Cells. Protein Cell. 2016, 7:820-32.封面文章（Cover Article） IF=10.164
专著：
1.《病理生理学精讲精练》，世界图书出版社
2.《病理生理学实验指导》，人民卫生出版社
3.《病理生理学》，复旦大学出版社
专利：
一种弹性导电胶体、制备方法及应用，专利授权号：ZL 201510004341.0
人类多能干细胞来源的人类心室肌细胞的筛选于制备方法，专利申请号：201611271273.5
一种治疗心力衰竭的复方制剂，专利申请号：201810862112.6
ABRA在制备改善扩张型心肌病功能药物中的用途，专利申请号：20190241255.X
