付永锋

  • 职称:副教授

  • 职务:无

  • 电子邮箱:yffu@fudan.edu.cn

  • 办公地点:枫林校区东一号楼323室

  • 电话:021-54237750

  • 个人网页/课题组主页:

  • 研究方向

  • 学术任职

  • 重要学术贡献

  • 科研成果

  • 方向一 医学原虫分子致病机制及其诊断研究

  • 方向二 高通量病原检测技术研究

国内外:

  • 2015-今 上海市预防医学会媒介生物预防与控制专业委员会 委员

  • 2008-今 中华预防医学会医学寄生虫分会 会员

       从事“医学原虫弓形虫分子致病及高通量病原检测技术研究”,通过制备高活性病原蛋白分子诊断标记物,结合蛋白芯片和微流控技术,建立免疫微流控芯片检测方法,开发高通量自动检测系统用于隐孢子虫病、尘螨变应原特异性IgE抗体等血清学检测。在SENSOR ACTUAT B-CHEM、Front Microbiol等杂志上发表论文12篇,授权专利6项。

发表论文:

  • Dai B, Yin C, Wu JD,  Li W,  Zheng LL,  Lin F,  Han XD, Fu YF*, Zhang DW,  Zhuang SL:A flux-adaptable pump-free microfluidics-based self-contained platform for multiplex cancer biomarker detection. Lab on a chip 2021, 21(1):143-153

  • Fu YF, Li W, Dai B, Zheng LL, Zhang ZG, Qi DM, Cheng XJ*, Zhang DW*, Zhuang SL: Diagnosis of mixed infections with swine viruses using an integrated microfluidic platform.Sensors & Actuators: B. Chemical 2020, 312:128005.

  • Dai B, Chen SJ, Li W, Zheng LL, Han XD, Fu YF*, Wu JD, Lin F, Zhang DW*, Zhuang SL: Fully-functional semi-automated microfluidic immunoassay platform forquantitation of multiple samples.Sensors & Actuators: B. Chemical 2019, 300:127017.

  • Zhou J, Wang Q, Zhu L, Li S, Li W, Fu Y*, Cheng X*: Development and evaluation of a rapid detection assay for severe fever with thrombocytopenia syndrome virus based on reverse-transcription recombinase polymerase amplification.Mol Cell Probes 2020, 52:101580.

  • Man S*, Fu Y*, Guan Y, Feng M, Qiao K, Li X, Gao H, Cheng X: Evaluation of a Major Surface Antigen of Babesia microti Merozoites as a Vaccine Candidate against Babesia Infection.Front Microbiol 2017, 8:2545.

  • Fu Y, Li S, Zhang Z, Man S, Li X, Zhang W, Zhang C, Cheng X: Phylogeographic analysis of severe fever with thrombocytopenia syndrome virus from Zhoushan Islands, China: implication for transmission across the ocean.Sci Rep 2016, 6:19563.

  • Man SQ, Qiao K, Cui J, Feng M, Fu YF*, Cheng XJ: A case of human infection with a novel Babesia species in China. Infect Dis Poverty 2016, 5:28.

  • 8.Zheng L*, Fu Y*, Jiang X, Man S, Ran W, Feng M, Liu S, Cheng X, Sui G: Microfluidic system for high-throughput immunoglobulin-E analysis from clinical serum samples.Talanta 2015, 143:83-89.

  • Wang X*, Fu YF*, Wang RY, Li L, Cao YH, Chen YQ, Zhao HZ, Zhang QQ, Wu JQ, Weng XH, Cheng XJ, Zhu LP: Identification of clinically relevant fungi and prototheca species by rRNA gene sequencing and multilocus PCR coupled with electrospray ionization mass spectrometry. PLoS One 2014, 9(5):e98110.

  • Fu YF, Feng M, Ohnishi K, Kimura T, Itoh J, Cheng XJ, Tachibana H: Generation of a neutralizing human monoclonal antibody Fab fragment to surface antigen 1 of Toxoplasma gondii tachyzoites.Infect Immun 2011, 79(1):512-517.

专利:

  • 一种抗刚地弓形虫表面抗原1人源抗体FAB片段及其编码基因。授权号:200910141029.0。授权时间:2011年12月。

  • 溶组织内阿米巴半乳糖/乙酰氨基半乳糖多肽片段及其制备方法和应用。授权号:201110001097.4。授权时间:2013年08月。(已转让)

  • 粉尘螨2类变应原特异的人源单抗IgG Fab片段及其制备方法与用途。授权号:200910051875.3。授权时间:2013年07月。

  • 一种人源抗人IgE的抗体Fab片段、编码基因及用途。授权号:201110325885.9。授权时间:2014年1月。

  • 基于微流控芯片的高通量快速检测疟疾血清的方法;授权号:CN201110105343;授权日 2016.02.24

  • 基于微流控芯片和蛋白质芯片检测血清过敏原特异性的IgE的方法;授权号:CN201410271147.4;授权日: 2018.01.16