刘贇
发表时间：2017-11-08 阅读次数：4690次
刘贇，复旦大学基础医学院生物化学与分子生物学系研究员
联系方式
E-MAIL: yliu39@fudan.edu.cn
实验室网址：
liulab.fudan.edu.cn
研究方向
1. DNA甲基化在自身免疫性疾病（如类风湿关节炎）及肿瘤发生中的作用
2. DNA甲基化作为分子标志物在疾病临床诊疗中的运用
重要学术贡献
刘贇课题组研究方向主要集中于运用表观遗传组学的方法，研究人类复杂疾病的成因，以及致病的生化机理机制。2013年，运用全基因组DNA甲基化谱的手段，第一次揭示了DNA甲基化对类风湿关节炎病的发生的关系。这项工作发表于Nature Biotechnology上。除此以外，课题组在此领域的其它学术成果还被发表在 Nature Genetics、Immunity、The American Journal of Human Genetics等国际第一流的学术科研期刊上。在过去5年中，论文共被他引800多次，所作出的学术成果受到包括纽约时报在内的多家主要媒体广泛报道。担任Nature Communications、Epigenetics、Arthritis Research and Therapy等杂志审稿人。2009年获美国约翰霍普金斯大学32nd Young Investigator Award奖项，2014年入选入选国家高层次人才计划。
荣誉与获奖
2009 美国约翰霍普金斯大学32nd Young Investigator Award奖项
2014 入选国家高层次人才计划
国内外学术团体任职
2018-至今 上海市医学会医学遗传学专科分会委员
代表性论文（# 第一作者；* 通讯作者）
1. Meng, W.#, Sjöholm, LK.#, Kononenko, O.#, Tay, N.#, Zhang, D.#, Sarkisyan, D.#, Geske, JR., Ing, A., Qiu, W., Watanabe, H., Almamoun, R., Frieling, H., Bleich, S., Cui, D., Biernacka, JM., Mayfield, RD., Dang, Y., Karpyak, VM., Schumann, G.; IMAGEN Consortium, Bakalkin, G.#, Ekström, TJ.#,*, Rüegg, J.#, Liu, Y.#,* Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence. Mol Psychiatry. (2019) doi: 10.1038/s41380-019-0588-9. (影响因子: 11.64)
2. Qiu, W., Xu, Z., Zhang, M., Zhang, D., Fan, H., Li, T., Wang, Q., Liu, P., Zhu, Z., Du, D., Tan, M., Wen, B., Liu, Y.*. Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system. Nucleic Acids Res. (2019) doi: 10.1093/nar/gkz134 (影响因子: 11.56)
3. Tay N#, Macare C#, Liu Y#, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J#, Ekström TJ#, Bakalkin G#, Schumann G#,*; IMAGEN Consortium. Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse. American Journal of Psychiatry. (2019) 176(2):146-155 (影响因子: 13.40)
4. Cai, M., Zhu, Y., Li, Z., Josephs-Spaulding, J., Zhou, Y., Hu, Y., Chen, H., Liu, Y.*, He, W.*, Zhang, J.* Profiling the Gene Expression and DNA Methylation in the Mouse Brain after Ischemic Preconditioning. Neuroscience. (2019) 406:249-261
5. Kular, L.#, Liu, Y.#, et al., DNA methylation as a mediator of HLA-DRB1* 15: 01 and a protective variant in multiple sclerosis. Nat. Commun. (2018) 9(1):2397(影响因子: 12.35)
6. Zhu, Z., Meng, W., Liu, P., Zhu, X., Liu, Y.*, Zou, H.* DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding. Clin Epigenetics (2017) 9:99
7. Meng, W., Zhu, Z., Jiang, X., Too, CL., Uebe, S., Jagodic, M., Kockum, I., Murad, S., Ferrucci, L., Alfredsson, L., Zou, H., Klareskog, L., Feinberg, AP., Ekström, TJ., Padyukov, L.*, Liu, Y. * DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis. Arthritis Res Ther (2017) 19:71
8. Liu, Y.#, Duong, W.#, Krawczyk, C., Bretschneider, N., Borbely, G., Varshney, M., Zinser, C., Schar, P., Ruegg, J.* Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase. Epigenetics & Chromatin (2016) 9:7
9. Liu, Y.#, Li, X.#, Aryee, MJ., Ekstrom, TJ., Padyukov, L., Klareskog, L., Vandiver, A., Moore, AZ., Tanaka, T., Ferrucci, L., Fallin, MD.*, Feinberg, AP.* GeMes: Clusters of DNA methylation under genetic control can inform genetic and epigenetic analysis of disease. Am J Hum Genet (2014) 94:485-495 (影响因子: 10.8)
10. Liu, Y.#, Aryee, MJ.#, Padyukov, L.#, Fallin, MD.#, Hesselberg, E., Runarsson, A., Reinius, L., Acevedo, N., Taub, M., Ronninger, M., Shchetynsky, K., Scheynius, A., Kere, J., Alfredsson, L., Klareskog, L.*, Ekstrom, TJ.*, Feinberg, AP.* Epigenome-wide association data implicate DNA methylation as an intermediary of generic risk in Rheumatoid Arthritis. Nat. Biotechnol. (2013) 31:142-147 (影响因子: 43.1)
11. Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. and Desiderio, S.* A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement. Immunity. (2007) 27:561-571 (封面故事, 影响因子: 24.1)