刘贇

  • 职    称: 研究员

  • 联系电话: 021-5423-7278

  • 电子邮箱: yliu39@fudan.edu.cn

  • 办公地点: 上海市东安路131号二号科研楼A4-015

  • 个人主页/课题组网页: https://liulab.fudan.edu.cn/

  • 教育经历

  • 工作经历

  • 获得人才项目

  • 研究方向

  • 科研项目

  • 课程讲授

  • 学术兼职

  • 代表性论著

  • 2003/09-2009/09,美国约翰霍普金斯大学,医学院分子生物与遗传学系,博士

  • 2007/09-2009/09,美国约翰霍普金斯大学,公共卫生学院生物统计学系,硕士

  • 1999/09-2003/07,复旦大学,生命科学学院,学士

  • 2014/06-至今,复旦大学,基础医学院生物化学与分子生物学系,研究员

  • 2009/10-2014/05,美国约翰霍普金斯大学,医学院表观遗传中心,博士后

  • 2020年 上海市优秀学术带头人(青年)

  • 2014年 国家高层次人才计划

  • DNA甲基化在人类常见病及肿瘤发生中的机理机制;

  • DNA甲基化作为分子标志物,在个体精准诊疗中的临床运用。

  • 2021,国家自然科学基金面上项目,“自闭症相关基因DLGAP2的鉴定及致病机制研究”,主持

  • 2021,科技部重点研发计划,“儿童结构性出生缺陷防控和救助体系的构建及示范应用”,参与

  • 2020,上海市科委优秀学术带头人(青年),“人类常见病的表观遗传调控及机制研究”,主持

  • 2020,上海市科委面上,“酒精成瘾相关蛋白DLGAP2介导下的液-液相分离结构及其对突出信号传递的影响”,主持

  • 2018,国家自然科学基金面上项目,“ORMDL3在类风湿关节炎中的作用及机制研究”,主持

  • 2015,国家自然科学基金面上项目,“人类淋巴母细胞系中基因与DNA甲基化上位效应对基因表达作用的研究”,主持

本科生课程:

  • 生物化学、脑科学前沿

研究生课程:

  • 医学人工智能与机器学习、分子医学导论、医学分子生物学

  • 2020-今 全国卫生产业企业管理协会精准医疗分会 理事

  • 2018-今 上海市医学会医学遗传学专科分会 委员

  1. Meng, W.#, Sjöholm, LK.#, Kononenko, O.#, Tay, N.#, Zhang, D.#, Sarkisyan, D.#, Geske, JR., Ing, A., Qiu, W., Watanabe, H., Almamoun, R., Frieling, H., Bleich, S., Cui, D., Biernacka, JM., Mayfield, RD., Dang, Y., Karpyak, VM., Schumann, G.; IMAGEN Consortium, Bakalkin, G.#, Ekström, TJ.#,*, Rüegg, J.#, Liu, Y.#,* Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence. Mol Psychiatry. (2021) 26(8):4367-4382. (影响因子: 11.64)

  2. Qiu, W., Xu, Z., Zhang, M., Zhang, D., Fan, H., Li, T., Wang, Q., Liu, P., Zhu, Z., Du, D., Tan, M., Wen, B., Liu, Y.*. Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system. Nucleic Acids Res. (2019) doi: 10.1093/nar/gkz134 (影响因子: 11.56)

  3. Tay N#, Macare C#, Liu Y#, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J#, Ekström TJ#, Bakalkin G#, Schumann G#,*; IMAGEN Consortium. Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse. American Journal of Psychiatry. (2019) 176(2):146-155 (影响因子: 13.40)

  4. Kular L#, Liu Y#, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M, Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U, Schmidt CO, Kacprowski T, Franke A, Laudes M, Dilthey AT, Celius EG, Søndergaard HB, Tegnér J, Harbo HF, Oturai AB, Olafsson S, Eggertsson HP, Halldorsson BV, Hjaltason H, Olafsson E, Jonsdottir I, Stefansson K, Olsson T, Piehl F, Ekström TJ, Kockum I#, Feinberg AP#,*, Jagodic M#,* DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis. Nature Communications. (2018) 9:2397 (影响因子: 12.35)

  5. Zhu, Z., Meng, W., Liu, P., Zhu, X., Liu, Y.*, Zou, H.* DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding. Clin Epigenetics (2017) 9:99

  6. Meng, W., Zhu, Z., Jiang, X., Too, CL., Uebe, S., Jagodic, M., Kockum, I., Murad, S., Ferrucci, L., Alfredsson, L., Zou, H., Klareskog, L., Feinberg, AP., Ekström, TJ., Padyukov, L.*, Liu, Y. * DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis. Arthritis Res Ther (2017) 19:71

  7. Liu, Y., Duong, W., Krawczyk, C., Bretschneider, N., Borbely, G., Varshney, M., Zinser, C., Schar, P., Ruegg, J. Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase. Epigenetics & Chromatin (2016) 9:7

  8. Liu, Y., Li, X., Aryee, MJ., Ekstrom, TJ., Padyukov, L., Klareskog, L., Vandiver, A., Moore, AZ., Tanaka, T., Ferrucci, L., Fallin, MD., Feinberg, AP. GeMes: Clusters of DNA methylation under genetic control can inform genetic and epigenetic analysis of disease. Am J Hum Genet (2014) 94:485-495 (影响因子: 11.2)

  9. Liu, Y., Aryee, MJ., Padyukov, L., Fallin, MD., Hesselberg, E., Runarsson, A., Reinius, L., Acevedo, N., Taub, M., Ronninger, M., Shchetynsky, K., Scheynius, A., Kere, J., Alfredsson, L., Klareskog, L., Ekstrom, TJ., Feinberg, AP. Epigenome-wide association data implicate DNA methylation as an intermediary of generic risk in Rheumatoid Arthritis. Nat. Biotechnol. (2013) 31:142-147 (影响因子: 32.44)

  10. Comment in Nature Rev Rheumatol.

    Highlights:The New York Times (http://www.nytimes.com/2013/01/21/health/study-pinpoints-what-activates-disease-causing-genes.html)


  11. Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. and Desiderio, S. A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement. Immunity. (2007) 27:561-571 (封面故事, 影响因子: 21.64)

    Preview:Targeting V(D)J recombinase: putting a PHD to work. Immunity

    Highlights:Faculty of 1000 (http://f1000.com/prime/1092746)