• 细胞生物学：蛋白质机器与细胞命运

• 医学免疫学：抗病毒感染与免疫

• 医学蛋白质组：生物前沿技术与抗体药物研发

主要从事感染、免疫和肿瘤发生研究，揭示了机体抗病毒感染以及炎症诱发肿瘤相关的重要分子事件，为自身免疫性疾病治疗和干预炎症促发肿瘤的进程提供了基础。近年来主要科研成果发表在Cell、Nature Immunology、Nature Cell Biology等著名学术杂志，其中“基于DNA感受器调控的自身免疫性疾病治疗方案”入选2019年度中国科学十大进展。

• 荣获谈家桢生命科学成就奖、何梁何利基金奖、国家自然科学奖、国家科技进步创新团队奖等。

发表论文：

• Acetylation blocks cGAS activity and inhibits self-DNA-induced autoimmunity. Cell. 2019, 176 (6), 1447-1460.e14.

• AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression. Nature Cell Biology. 2019, Apr; 21 (4):476-486.

• G3BP1 promotes DNA binding and activation of cGAS. Nature Immunology. 2018, Jan; 20 (1):18-28.

• Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. Nature Communications. 2018, Dec 11; 9 (1):5277.

• SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores. Nature Communications. 2016 Oct 3; 7:12969.

• NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Nature Communications. 2014 Jul 29; 5:4513.

• Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. Nature Medicine. 2011 Jun; 17(6):708-14.

• Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability. Nature Cell Biology. 2011 Jul 10; 13(8):924-33.

• Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells. J Clin Invest. 2010 Aug; 120 (8):2829-41.

• Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nature Immunology. 2008, 9(5):533-41.