职称:教授
电话:021-54237569
电子邮箱:jhxie@fudan.edu.cn
办公地点:上海市东安路131号法医楼306室
教育经历:
2003.09-2008.06,复旦大学上海医学院生物化学与分子生物学系,博士
1998.09-2003.06,复旦大学上海医学院(原上海医科大学),本科
工作经历:
2012.07-今,复旦大学基础医学院法医学系
2008.07-2012.06,复旦大学上海医学院生物化学与分子生物学系
获得人才项目:
2014,复旦大学卓学人才计划
获得奖项:
2018,复旦大学第一三共制药奖教金
研究方向:
1.疑难法医生物检材检测,发展新型检测方法技术、检测体系及检测结果解释算法,为疑难生物检材来源个体的个体识别提供策略
2. 复杂亲缘关系鉴定,发展新型检测体系和结果解释算法,为复杂亲缘关系鉴定及个体排查提供策略
科研项目:
l国家自然科学面上项目(31270862、81571853、82171875)
l国家自然科学青年基金(30900266)
l教育部博士点基金新教师类(20090071120053)
l上海市刑事科学技术研究院重点实验室开放课题(2017XCWZK09)
课程教材:
l本科生课程讲授:
法医物证学、法医人类学、法医学、法医学概论等
l研究生课程讲授:
法医生物学、高级法医学
l教材:
《法医物证学》人卫出版社、第四版、编委
《法医学》复旦大学出版社、副主编
《forensic Medicine》人卫出版社、编委
学术兼职:
l上海司法鉴定协会法医物证专业副主任委员
l中国遗传学会法医遗传学分会委员
l中国法医学会法医物证专业委员
l上海市法医学会理事
l法医学杂志、Genes杂志编委
代表性论著:
一、法医STR变异规律和特征研究
1.Yang Q, Yao Y, Shao C, Zhou Y, Li H, Li C, Tang Q, Xie J*. Calculation of the Paternity Index for STR with tri-allelic patterns in paternity testing. Forensic Sci Int. 2021:110832.
2.Yang Q, Shen Y, Shao C, Liu Y, Xu H, Zhou Y, Liu Z, Sun K, Tang Q, Xie J*. Genetic analysis of tri-allelic patterns at the CODIS STR loci. Mol Genet Genomics. 2020; 295(5):1263-68.
3.Yang Q, Li M, Sun K, Wang Q, Shao C, Liu Y, Xu H, Zhang S, Bian Y*, Gao Y*, Li C*, Liu Y*, Xie J*. Genetic analysis of type 2 tri-allelic pattern at TPOX locus in the Chinese Han population. Mol Genet Genomics. 2020; 295(4):933-39.
4.Yang Q, Liu B, Shao C, Zhou Y, Yao Y, Pan Y, Sun K, Xu H, Li C, Wei T, Zhou Y, Tang Q, Xie J*. Characterization of the extra copy of TPOX locus with tri-allelic pattern. BMC Genet. 2019; 20(1):18.
5.Yao Y, Yang Q, Shao C, Liu B, Zhou Y, Xu H, Zhou Y, Tang Q, Xie J*. Null alleles and sequence variations at primer binding sites of STR loci within multiplex typing systems. Leg Med (Tokyo). 2018; 30:10-13.
6.Shao C, Lin M, Zhou Z, Zhou Y, Shen Y, Xue A, Zhou H, Tang Q, Xie J*. Mutation analysis of 19 autosomal short tandem repeats in Chinese Han population from Shanghai. Int J Legal Med. 2016; 130(6):1439-44.
二、疑难生物检材检测策略研究
1.Yao Y, Sun K, Yang Q, Zhou Z, Shao C, Qian X, Tang Q, Xie J*. Assessing autosomal InDel loci with multiple insertions or deletions of random DNA Sequences in human genome. Front Genet. 2022; 12: 809815.
2.Yang Q, Liu B, Zhou Y, Yao Y, Zhou Z, Li H, Shao C, Sun K, Xu H, Tang Q, Shen Y*, Xie J*. Evaluation of one-step RT-PCR multiplex assay for body fluid identification. Int J Legal Med. 2021; 135(5):1727-1735.
3.Liu B, Yang Q, Meng H, Shao C, Jiang J, Xu H, Sun K, Zhou Y, Yao Y, Zhou Z, Li H, Shen Y, Zhao Z, Tang Q, Xie J*. Development of a multiplex system for the identification of forensically relevant body fluids. Forensic Sci Int Genet. 2020; 47:102312.
4.Liu B, Song F, Yang Q, Zhou Y, Shao C, Shen Y, Zhao Z, Tang Q, Hou Y, Xie J*. Characterization of tissue-specific biomarkers with the expression of circRNAs in forensically relevant body fluids. Int J Legal Med. 2019; 133(5):1321-31.
5.Sun K, Yun L, Zhang C, Shao C, Gao T, Zhao Z, Hou Y, Xie J*, Tang Q*. Evaluation of 12 Multi-InDel markers for forensic ancestry prediction in Asian populations. Forensic Sci Int Genet. 2019; 43:102155.
6.Zhang Y, Liu B, Shao C, Xu H, Xue A, Zhao Z, Shen Y*, Tang Q, Xie J*. Evaluation of the inclusion of circular RNAs in mRNA profiling in forensic body fluid identification. Int J Legal Med. 2018; 132(1):43-52.
三、复杂亲缘关系鉴定研究
1.Zhou Z, Zhou Y, Li Z, Yao Y, Yang Q, Qian J, Shao C, Qian X, Sun K, Tang Q, Xie J*. Identification and assessment of a subset of Y-SNPs with recurrent mutation for forensic purpose. Forensic Sci Int. 2022; 334:111270.
2.Zhou Z, Zhou Y, Yao Y, Qian J, Liu B, Yang Q, Shao C, Li H, Sun K, Tang Q, Xie J*. A 16-plex Y-SNP typing system based on allele-specific PCR for the genotyping of Chinese Y-chromosomal haplogroups. Leg Med (Tokyo). 2020; 46:101720.
3.Zhou Y, Yao Y, Liu B, Yang Q, Zhou Z, Shao C, Li S, Tang Q, Xie J*. Characterizing Y-STRs in the Evaluation of Population Differentiation Using the Mean of Allele Frequency Difference between Populations. Genes (Basel). 2020; 11(5): 566.
4.Zhou Y, Shao C, Li L, Zhang Y, Liu B, Yang Q, Tang Q, Li S, Xie J*. Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai. Forensic Sci Int Genet. 2018; 32:e1-e4.
代表性专利:
一种人类常染色体InDel位点的荧光复合扩增检测试剂盒及其应用, 2022-2-21, 中国, CN202210157030.8 申请
一种检测人18个基因的转录产物的复合扩增试剂盒及其应用, 2019-11-15 , 中国, CN201911125324.7 申请