谢建辉


教授

话:021-54237569

电子邮箱:jhxie@fudan.edu.cn

办公地点:上海市东安路131号法医楼306





教育经历:

2003.09-2008.06,复旦大学上海医学院生物化学与分子生物学系,博士

1998.09-2003.06,复旦大学上海医学院(原上海医科大学),本科

  

工作经历:

2012.07-今,复旦大学基础医学院法医学系

2008.07-2012.06,复旦大学上海医学院生物化学与分子生物学系

  

获得人才项目:

2014,复旦大学卓学人才计划

  

获得奖项:

2018,复旦大学第一三共制药奖教金

  

研究方向:

1.疑难法医生物检材检测,发展新型检测方法技术、检测体系及检测结果解释算法,为疑难生物检材来源个体的个体识别提供策略

2. 复杂亲缘关系鉴定,发展新型检测体系和结果解释算法,为复杂亲缘关系鉴定及个体排查提供策略

  

科研项目:

l国家自然科学面上项目(312708628157185382171875

l国家自然科学青年基金(30900266

l教育部博士点基金新教师类(20090071120053

l上海市刑事科学技术研究院重点实验室开放课题(2017XCWZK09

  

课程教材:

l本科生课程讲授:

法医物证学、法医人类学、法医学、法医学概论等

l研究生课程讲授:

法医生物学、高级法医学

l教材:

《法医物证学》人卫出版社、第四版、编委

《法医学》复旦大学出版社、副主编

forensic Medicine》人卫出版社、编委


学术兼职:

l上海司法鉴定协会法医物证专业副主任委员

l中国遗传学会法医遗传学分会委员

l中国法医学会法医物证专业委员

l上海市法医学会理事

l法医学杂志、Genes杂志编委


代表性论著:

一、法医STR变异规律和特征研究

1.Yang Q, Yao Y, Shao C, Zhou Y, Li H, Li C, Tang Q, Xie J*. Calculation of the Paternity Index for STR with tri-allelic patterns in paternity testing. Forensic Sci Int. 2021:110832.

2.Yang Q, Shen Y, Shao C, Liu Y, Xu H, Zhou Y, Liu Z, Sun K, Tang Q, Xie J*. Genetic analysis of tri-allelic patterns at the CODIS STR loci. Mol Genet Genomics. 2020; 295(5):1263-68.

3.Yang Q, Li M, Sun K, Wang Q, Shao C, Liu Y, Xu H, Zhang S, Bian Y*, Gao Y*, Li C*, Liu Y*, Xie J*. Genetic analysis of type 2 tri-allelic pattern at TPOX locus in the Chinese Han population. Mol Genet Genomics. 2020; 295(4):933-39.

4.Yang Q, Liu B, Shao C, Zhou Y, Yao Y, Pan Y, Sun K, Xu H, Li C, Wei T, Zhou Y, Tang Q, Xie J*. Characterization of the extra copy of TPOX locus with tri-allelic pattern. BMC Genet. 2019; 20(1):18.

5.Yao Y, Yang Q, Shao C, Liu B, Zhou Y, Xu H, Zhou Y, Tang Q, Xie J*. Null alleles and sequence variations at primer binding sites of STR loci within multiplex typing systems. Leg Med (Tokyo). 2018; 30:10-13.

6.Shao C, Lin M, Zhou Z, Zhou Y, Shen Y, Xue A, Zhou H, Tang Q, Xie J*. Mutation analysis of 19 autosomal short tandem repeats in Chinese Han population from Shanghai. Int J Legal Med. 2016; 130(6):1439-44.

二、疑难生物检材检测策略研究

1.Yao Y, Sun K, Yang Q, Zhou Z, Shao C, Qian X, Tang Q, Xie J*. Assessing autosomal InDel loci with multiple insertions or deletions of random DNA Sequences in human genome. Front Genet. 2022; 12: 809815.

2.Yang Q, Liu B, Zhou Y, Yao Y, Zhou Z, Li H, Shao C, Sun K, Xu H, Tang Q, Shen Y*, Xie J*. Evaluation of one-step RT-PCR multiplex assay for body fluid identification. Int J Legal Med. 2021; 135(5):1727-1735.

3.Liu B, Yang Q, Meng H, Shao C, Jiang J, Xu H, Sun K, Zhou Y, Yao Y, Zhou Z, Li H, Shen Y, Zhao Z, Tang Q, Xie J*. Development of a multiplex system for the identification of forensically relevant body fluids. Forensic Sci Int Genet. 2020; 47:102312.

4.Liu B, Song F, Yang Q, Zhou Y, Shao C, Shen Y, Zhao Z, Tang Q, Hou Y, Xie J*. Characterization of tissue-specific biomarkers with the expression of circRNAs in forensically relevant body fluids. Int J Legal Med. 2019; 133(5):1321-31.

5.Sun K, Yun L, Zhang C, Shao C, Gao T, Zhao Z, Hou Y, Xie J*, Tang Q*. Evaluation of 12 Multi-InDel markers for forensic ancestry prediction in Asian populations. Forensic Sci Int Genet. 2019; 43:102155.

6.Zhang Y, Liu B, Shao C, Xu H, Xue A, Zhao Z, Shen Y*, Tang Q, Xie J*. Evaluation of the inclusion of circular RNAs in mRNA profiling in forensic body fluid identification. Int J Legal Med. 2018; 132(1):43-52.

三、复杂亲缘关系鉴定研究

1.Zhou Z, Zhou Y, Li Z, Yao Y, Yang Q, Qian J, Shao C, Qian X, Sun K, Tang Q, Xie J*. Identification and assessment of a subset of Y-SNPs with recurrent mutation for forensic purpose. Forensic Sci Int. 2022; 334:111270.

2.Zhou Z, Zhou Y, Yao Y, Qian J, Liu B, Yang Q, Shao C, Li H, Sun K, Tang Q, Xie J*. A 16-plex Y-SNP typing system based on allele-specific PCR for the genotyping of Chinese Y-chromosomal haplogroups. Leg Med (Tokyo). 2020; 46:101720.

3.Zhou Y, Yao Y, Liu B, Yang Q, Zhou Z, Shao C, Li S, Tang Q, Xie J*. Characterizing Y-STRs in the Evaluation of Population Differentiation Using the Mean of Allele Frequency Difference between Populations. Genes (Basel). 2020; 11(5): 566.

4.Zhou Y, Shao C, Li L, Zhang Y, Liu B, Yang Q, Tang Q, Li S, Xie J*. Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai. Forensic Sci Int Genet. 2018; 32:e1-e4.

  

代表性专利:

  1. 一种人类常染色体InDel位点的荧光复合扩增检测试剂盒及其应用, 2022-2-21, 中国, CN202210157030.8 申请

一种检测人18个基因的转录产物的复合扩增试剂盒及其应用, 2019-11-15 , 中国, CN201911125324.7 申请