米文丽
博士、副教授、博士生导师
研究方向：
1. 慢性疼痛及针刺/中药/运动镇痛的神经生物学机制研究
2. 慢性瘙痒及针刺/中药止痒的神经生物学机制研究
率先在国际上研究并报道了中枢IL-33/ST2通路在急慢性疼痛、瘙痒及吗啡耐受中的作用及机制，已发表第一或通讯作者SCI论文16篇、SCI综述4篇，累计影响因子逾百分,包括Science Signaling, Anesthesiology, Glia, Phytomedicine, Analgesia & Anesthesia等专业领域权威期刊，另参与SCI论文30余篇；获国家专利授权5项。
先后主持国家自然科学基金青年/面上项目（3项）、教育部博士点新教师基金、上海市自然科学基金等，科技创新2030-脑科学与类脑研究重大项目研究骨干，上海市教委高水平地方高校试点建设创新团队成员。入选中英联合创新基金暨牛顿基金(上海)、复旦大学上海医学院研究学者、复旦大学卓学计划和复旦大学基础医学院尚学计划。兼任上海市疼痛医学会青年委员会副主任委员、中国神经科学学会胶质细胞委员会委员、中国中西医结合学会科研院所委员会委员、中国针灸学会针麻分会委员。
学习和工作简历：
2015.12 - ，复旦大学基础医学院中西医结合学系副教授
2013.11- 2014.11，美国哈佛大学医学院附属麻省总医院博士后
2009.7 - 2015.12，复旦大学基础医学院中西医结合学系讲师
2004.9 - 2009.6，复旦大学上海医学院中西医结合基础专业研究生（硕博连读）
1999.9 - 2004.7，新乡医学院临床医学专业本科
论文论著：
仅列出第一作者和通讯作者（*）论文：
1. Chenghao Wang1, Hui He1, Tianchi Gao, Xinzheng Sun, Lixia Du, Yayue Yang, Jianyu Zhu, Yachen Yang, Yanqing Wang, Wenli Mi*. Analgesic Effect of Exercise on Neuropathic Pain via Regulating the Complement Component 3 of Reactive Astrocytes. Anesthesia & Analgesia. 2024 Jan 31. doi: 10.1213/ANE.0000000000006884.
2．Tianchi Gao1, Chenghao Wang1，Yanqing Wang，Wenli Mi*. IL-33/ST2 Signaling in the Pathogenesis of Chronic Pain and Itch. Neuroscience 529 (2023) 16–22.（综述，封面文章）
3. Yayue Yang1, Lixia Du1, Jianyu Zhu, Ting Yi, Yachen Yang, Zheng Qiao, Qiliang Maoying, Yuxia Chu, Yanqing Wang, Wenli Mi*. Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling. Phytomedicine. 2023 119:154969.
4.Xinyi Gao1, Yayue Yang1, Jianyu Zhu, Yuxin Zhang, Chenghao Wang, Zhifei Wang*, Wenli Mi*, Lixia Du*. Xanthotoxol relieves itch in mice via suppressing spinal GRP/GRPR signaling. European Journal Of Pharmacology. 2023: 960:176147.
5.Ling Xu，Mingzhe Liu; Yayue Yang; Yan Wang; Xiaoxiao Hua; Lixia Du; Jianyu Zhu; Yang Shen; Yanqing Wang; Ling Zhang; Wenli Mi*; Di Mu*; Geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice, Phytomedicine, 2022,153965.
6. Lixia Du*, Jianyu Zhu, Wenli Mi*. Cytokines and Chemokines Modulation of Itch. Neuroscience. 2022 Jul 15:495:74-85. Review
7. Hu Xueming, Yang Wei, Zhang Mengting, Du Lixia, Tian Jiahe, Zhu Jianyu, Chen Yu, Hai Feng, Liu Shenbin, Maoying Qiliang, Chu Yuxia, Zhou Hong, Wang Yanqing*, Mi Wenli*. Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance. Science Signaling. 2021 Sep 7;14(699):eabe3773.（封面文章，Faculty Opinion推荐点评）
8. Lixia Du, Xueming Hu, Wei Yang, Hanikezi Yasheng, Shenbin Liu, Wenwen Zhang, Yang Zhou, Wenqiang Cui, Jianyu Zhu, Zheng Qiao, Qiliang Maoying, Yuxia Chu, Hong Zhou, Yanqing Wang, Wenli Mi*. Spinal IL-33/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2-STAT3 cascade. Glia. 2019 67(9):1680-1693.
9. Lixia Du, Yanqing Wang, Guoqiang Hua, Wenli Mi*. IL-33/ST2 Pathway as a Rational Therapeutic Target for CNS Diseases. Neuroscience 2018 369: 222–230.
10. Wenli Mi, Shuxing Wang, Zerong You, Grewo Lim, Michael F. McCabe, Hyangin Kim, Lucy Chen, Jianren Mao*. Nortriptyline Enhances Morphine-Conditioned Place Preference in Neuropathic Rats: Role of the Central Noradrenergic System. Anesthesia & Analgesia. 2017 125(3):1032-1041.
11. Shenbin Liu1, Qian Li1, Mengting Zhang, Qiliang Maoying, Langyue Hu, Gencheng Wu, Wen-Li Mi*, Yanqing Wang*. Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling. Scientific Reports, 2016;6:28956.
12. Shenbin Liu1, Wenli Mi1, Qian Li, Mengting Zhang, Ping Han, Shan Hu, Qiliang Maoying, Yanqing Wang*. Spinal IL-33/ST2 signaling contributes to neuropathic pain via neuronal CaMKII-CREB and astroglial JAK2-STAT3 cascades in mice. Anesthesiology, 2015 123(5):1154-1169.
13. Ping Han1, Shenbin Liu1, Mengting Zhang1, Jing Zhao, Yanqing Wang, Gencheng Wu, Wenli Mi*.Inhibition of spinal Interlukin-33/ST2 signaling and downstream ERK and JNK pathways in electroacupuncture analgesia in formalin mice. PLOS ONE, 0129576, 12, 2015.
14. Ping Han, Jing Zhao, Shen-Bin Liu, Chang-Jiang Yang, Yan-Qing Wang, Gen-Cheng Wu, Da-Mo Xu, Wen-Li Mi*. Interleukin-33 mediates formalin-induced inflammatory pain in mice. Neuroscience, 241:59-66, 2013
15. Wen-Li Mi, Qi-Liang Mao-Ying, Xiao-Wei Wang, Xiu Li, Chang-Jiang Yang, Jian-Wei Jiang, Jin Yu, Jun Wang, Qiong Liu, Yan-Qing Wang*, Gen-Cheng Wu. Involvement of spinal neurotrophin-3 in the electroacupuncture analgesia and inhibition of spinal glial activation in rat model of monoarthritis. Journal of Pain. 2011 12(9):974-84.
部分参编专著教材：
1. 感觉，225-256页，《医学神经科学基础》，孙凤艳主编，复旦大学出版社，2023年2月出版
2. Wenli Mi*, Lixia Du, Yayue Yang. Itch and the Antipruritic Effect of Acupuncture. 2022：515-538，In: Xia, Y. (eds) Advanced Acupuncture Research: From Bench to Bedside. Springer. （英文专著）
3. Qi-Liang Mao-Ying, Wen-Li Mi. Acupuncture Analgesia in Clinical Practice. Ying Xia, Xiaoding Cao, Gencheng Wu, Jieshi Cheng主编. 2009, 162-193.（英文专著）
部分国家授权发明专利：
1.米文丽，毛应启梁，杜利霞，王彦青，一种慢性瘙痒动物模型的制备器， ZL201820822114.8
2.米文丽，杨晓彤，王彦青，一种简易型电动抚触装置, ZL202223574272.1
3.米文丽，柳申滨，赵静，韩萍，王彦青，抗ST2/IL-1 R4抗体在制备镇痛药物中的用途， ZL201210517242.9
4.米文丽，史甜甜，杨天，王彦青，抗ST2/IL-1 R4抗体在制备防治瘙痒药物中的应用， ZL201210517244.8
联系方式：
Email wenlimi@fudan.edu.cn
电话 021-54237611
通讯地址 上海市东安路130号复旦大学上海医学院西13号楼711室（邮编：200032）