汪 军

博士、副教授、硕士生导师、教学、研究生招生培养助理
 

研究方向：

     针刺与中药改善神经退行性疾病的神经免疫机制    

学习和工作简历

        1996年毕业于上海医科大学获学士学位，同年留校，历任助教（1996~），讲师（2001~），副教授（2009 ~）。2005年获复旦大学中西医结合基础硕士学位，2009年获复旦大学中西医结合基础博士学位。2007-2008年作为访问学者在美国Illinois Institute of Technology和Blood Center of Wisconsin进修，2013-2014年作为高级访问学者到哈佛大学医学院Dana-Farber Cancer Institute访学。

        主要研究内容为中枢胶质细胞在神经系统损伤中的作用机制及中西医结合防治脱髓鞘疾病的效应和免疫调节机制，研究工作曾获得国家自然科学基金、上海市科委创新性行动计划、国家攀登计划、“973”计划、国家重点研发计划等多项国家级与省部级基金资助，以通讯作者和第一作者在Signal Transduction & Target Therapy ，PNAS, Oncogene, Exp Neurol等SCI杂志发表论文二十余篇，申请发明专利两项。担任Signal Transduction & Target Therapy，Glia， Acta Pharmaceutica Sinica，、CNS Neurosci Ther、Clin Exp Immunol等SCI杂志审稿人。在阐明中枢胶质细胞在脱髓鞘疾病发病机制方面取得了许多重要的研究进展。2010年获得中国针灸学会科学技术三等奖，2016获中西医结合学会科技进步二等奖。任中国生理学会应激专业委员会委员、中国中西医结合学会青年工作专业委员会委员，上海市免疫学会中医药专业委员会委员,美国神经科学学会、亚太神经化学学会、中国神经科学学会、细胞生物学学会会员。

科研项目：

国家自然科学基金面上项目（82074538）：GSDMD细胞焦亡途径调控“疾病相关小胶质细胞(DAM)”表型介导针刺促进髓鞘修复的效应机制，2021.01-2024.12，55万，项目负责人

论文论著 （第一作者#，通讯作者*）： 

1. Sun JX, Zhu KY, Wang YM, Wang DJ, Zhang MZ, Sarlus H, Benito-Cuesta I, Zhao XQ, Zou ZF, Zhong QY, Feng Y, Wu S, Wang YQ, Harris RA, Wang J*. Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function. Acta Pharmacol Sin. 2023 Apr;44(4):766-779. （封面文章）

2.Wang Y, Sun J, Zhu K, Wang D, Zhao X, Zhang H, Wu S, Wang Y, Wang J*. Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination. J Neuroinflammation. 2023 Mar 25;20(1):83.

3.Zhang H, Wang D, Sun J, Wang Y, Wu S, Wang J*. Huperzine-A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation. Int J Mol Sci. 2022 Dec 19;23(24):16182. doi: 10.3390/ijms232416182. 

4.Gao S, Jiang Y, Chen Z, Zhao X, Gu J, Wu H, Liao Y, Sun H, Wang J*, Chen W*. Metabolic Reprogramming of Microglia in Sepsis-associated Encephalopathy: Insights from Neuroinflammation. Curr Neuropharmacol. 2022 Dec 16. doi: 10.2174/1570159X21666221216162606. 

5. Zou Z, Sun J, Kang Z, Wang Y, Zhao H, Zhu K, Wang J*. Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model. Evid Based Complement Alternat Med. 2020 Jul 4;2020:3205176

6. Chen Y, Sun JX, Chen WK, Wu GC, Wang YQ, Zhu KY, Wang J*. miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation. Signal Transduct Target Ther. 2019 Aug 16;4:27. doi: 10.1038/s41392-019-0061-x.

7. Zhu K, Sun J, Kang Z, Zou Z, Wu X, Wang Y, Wu G, Harris RA, Wang J*. Repurposing of omeprazole for oligodendrocyte differentiation and remyelination. Brain Res 2019 May 1;1710:33-42

8. Zhu K, Sun J, Kang Z, Zou Z, Wu G, Wang J*. Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance. Front Neurosci  2017 Jan 10;10:613.

9. Lou W, Chen Y, Zhu KY, Deng H, Wu T, Wang J*. Polyphyllin I Overcomes EMT-Associated Resistance to Erlotinib in Lung Cancer Cells via IL-6/STAT3 Pathway Inhibition. Biol Pharm Bull. 2017 Aug 1;40(8):1306-1313

10. Wang J#, Mikse O, Liao RG, Li Y, Tan L, Janne PA, Gray NS, Wong KK, Hammerman PS. Ligand associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3 dependent cancer cells. Oncogene. 2015 Apr 23;34(17):2167-77.

11. Tan L#, Wang J#(co-first), Tanizaki J, Huang ZF, Aref AR, Rusan M, Zhu SJ, Zhang YY, Ercan D, Liao RG , Capelletti M, Zhou WJ , Hur W , Kim N, Sim T, Gaudet S, Barbie DA, Yeh JJ, Yun CH, Hammerman PS, Mohammadi M, Janne PA, Gray NS. Development of covalent inhibitors that can overcome resistance to first generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77

12. Tian GX, Zhu XQ, Chen Y, Wu GC and Wang J*. Huperzine A inhibits CCL2 production in experimental autoimmune encephalomyelitis mice and in cultured astrocyte. Int J Immunopathol Pharmacol, 2013，26(3): p. 757-64.

13. Wang J^#*, Chen F, Zheng P, Deng W, Yuan J, Peng B, Wang R, Liu W, Zhao H, Wang Y and Wu G. Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice. Exp Neurol, 2012， 236(1): p. 79-87.

14. Wang J^#, Li J, Sheng X, Zhao H, Cao XD, Wang YQ and Wu GC*. Beta-adrenoceptor mediated surgery-induced production of pro-inflammatory cytokines in rat microglia cells. J Neuroimmunol, 2010, 223(1-2): p. 77-83.

15. Wang J^#, Zhao H, Cao XD: Neuroimmuno-effect of acupuncture on immune-mediated disorders, (Editors: Ying Xia, Xiaoding Cao, Gencheng Wu, Jieshi Cheng, Acupuncture therapy for neurological diseases: A neurobiological view).  TSINGHUA and Springer; 1st Edition 2010， pp365-388（英文专著）

联系方式 
Email：jwangf@shmu.edu.cn
电话： 021-54237526
通讯地址:上海市医学院路138号，复旦大学基础医学院中西医结合系291信箱，200032