复旦大学,青年研究员
地点:复旦大学上海医学院西七号楼323
主要研究方向为肿瘤代谢和肿瘤微环境。包括(1)关键代谢物或代谢酶与肿瘤免疫逃逸;(2)代谢物的经典功能和新功能;(3)亚细胞器重塑与肿瘤发生。主持国家自然科学(青年)和博士后面上等项目。相关成果发表在在Nature Cell Biology,National Science Review和Signal Transduction and Targeted Therapy等杂志。
教育经历
复旦大学 硕博 系统生物学 生物医学研究院 09/2013—06/2018
新乡医学院 学士 生物工程 生命科学技术学院 09/2009—06/2013
工作经历
复旦大学基础医学院 青年研究员 02/2023—至今
复旦大学附属肿瘤医院 博士后 05/2020—05/2022
复旦大学附属肿瘤医院 科研助理 09/2018—04/2020
代表性论著
Jin-Tao Li#, Hai Yang#, Ming-Zhu Lei#, Wei-Ping Zhu#, Ying Su, Kai-Yue Li, Wen-Ying Zhu, Jian Wang, Lei Zhang, Jia Qu, Lei Lv, Hao-Jie Lu, Zheng-Jun Chen, Lu Wang, Miao Yin, Qun-Ying Lei. Dietary folate drives methionine metabolism to promote cancer development by stabilizing MATIIA. Signal Transduction and Targeted Therapy. (IF: 38.1027), 2022 Jun 22;7(1):192.
Jin-Tao Li#, Kai-Yue Li#, Ying Su, Yuan Shen, Ming-Zhu Lei, Fan Zhang, Miao Yin, Zheng-Jun Chen, Wen-Yu Wen, Wei-Guo Hu, Dan Su, Jia Qu, Qun-Ying Lei. Diet High in Branched-chain Amino Acid Promotes PDAC Development by USP1-mediated BCAT2 Stabilization. National Science Review (IF: 23.1784). 2022 May 9(5): nwab212.
Jin-Tao Li#, Miao Yin#, Di Wang#, Jian Wang, Ming-Zhu Lei, Ye Zhang, Ying Liu, Lei Zhang, Shao-Wu Zou, Li-Peng Hu, Zhi-Gang Zhang, Yi-Ping Wang, Wen-Yu Wen, Hao-Jie Lu, Zheng-Jun Chen, Dan Su, Qun-Ying Lei. BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma. Nature Cell Biology (IF: 28.8243). 2020 Feb;22(2):167-174. Highlight by Nature Cell Biology.
Qi-Xiang Ma, Wen-Ying Zhu, Xiao-Chen Lu, Duo Jiang, Feng Xu, Jin-Tao Li, Lei Zhang, Ying-Li Wu, Zheng-Jun Chen, Miao Yin, Hai-Yan Huang, Qun-Ying Lei. BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16. Nature Metabolism(IF:13.51). 2022 Jan;4(1):106-122.
Ming-Zhu Lei, Xu-Xu Li, Zhang Ye, Jin-Tao Li, Fan Zhang, Yi-Ping Wang, Miao Yin, Jia Qu, Qun-Ying Lei. Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth. Signal Transduction and Targeted Therapy (IF:13.49). 2020 May 29;5(1):70
获得的基金项目
2024 国家自然科学基金(面上项目) No.82472642 主持 在研
2021 博士后面上项目 No.2021M690676 主持 结题
2020 国家自然科学基金(青年项目) No.82002951 主持 结题