张扬 博士 副高级工程师
个人简介:
张扬博士，复旦大学生物医学研究院副高级工程师。1997~2001年就读于浙江大学生物学专业本科；2001~2004年就读于浙江大学生物系生物信息学专业，获得硕士学位；2008~2012年就读于复旦大学生命科学学院生化与分子生物学专业，获得博士学位。2004年至今在复旦大学生物医学研究院蛋白质组学和系统生物学实验室工作，负责生物信息学方面的硬件与软件平台的架设，同时参与以蛋白质组学数据为核心的癌症生物标志物挖掘方法与糖蛋白质组学研究。在糖蛋白质组学研究中利用现有主流的质谱技术，开发了糖肽谱图自动化搜索平台，并在标准品与实际样品的测试中已取得较好的结果，相关软件有望投入到大规模的疾病蛋白质组学中。
代表性论文:
1. Shen, F.*, Y. Zhang*, Y. Yao, W. Hua, H. S. Zhang, J. S. Wu, P. Zhong and L. F. Zhou (2014). "Proteomic analysis of cerebrospinal fluid: toward the identification of biomarkers for gliomas." Neurosurg Rev 37(3): 367-380.
2. Liu, Y., W. Ying, Z. Ren, W. Gu, Y. Zhang, G. Yan, P. Yang, Y. Liu, X. Yin, C. Chang, J. Jiang, F. Fan, C. Zhang, P. Xu, Q. Wang, B. Wen, L. Lin, T. Wang, C. Du, J. Zhong, T. Wang, Q. Y. He, X. Qian, X. Lou, G. Zhang and F. Zhong (2014). "Chromosome-8-coded proteome of Chinese Chromosome Proteome Data set (CCPD) 2.0 with partial immunohistochemical verifications." J Proteome Res 13(1): 126-136.
3. Jin, H. *, Y. Zhang*, L. Q. Xie, H. L. Shen, C. Y. Fang, H. J. Lu, M. X. Gao, H. Z. Fan and P. Y. Yang (2014). "Multiple technical routes to obtain a proteomics expression profile of French liver samples." Analytical Methods 6(9): 2950-2958.
4. Jiang, Y., L. Guo, L. Q. Xie, Y. Y. Zhang, X. H. Liu, Y. Zhang, H. Zhu, P. Y. Yang, H. J. Lu and Q. Q. Tang (2014). "Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS." J Proteome Res 13(3): 1307-1314.
5. Liu, M., Y. Zhang, Y. Chen, G. Yan, C. Shen, J. Cao, X. Zhou, X. Liu, L. Zhang, H. Shen, H. Lu, F. He and P. Yang (2014). "Efficient and accurate glycopeptide identification pipeline for high-throughput site-specific N-glycosylation analysis." J Proteome Res 13(6): 3121-3129.
6. Yin, X., X. Liu, Y. Zhang, G. Yan, F. Wang, H. Lu, H. Shen and P. Yang (2014). "Rapid and sensitive profiling and quantification of the human cell line proteome by LC-MS/MS without prefractionation." Proteomics.
7. Yu, H., H. Shen, Y. Zhang, F. Zhong, Y. Liu, L. Qin and P. Yang (2014). "CAV1 Promotes HCC Cell Progression and Metastasis through Wnt/beta-Catenin Pathway." PLoS One 9(9): e106451.
8. Zhang, Y., C. Fang, H. Bao, H. Fan, H. Shen and P. Yang (2013). "Nuclear proteome profile of C57BL/6J mouse liver." Sci China Life Sci 56(6): 513-523.
9. Zhang, Y., G. Yan, L. Zhai, S. Xu, H. Shen, J. Yao, F. Wu, L. Xie, H. Tang, H. Yu, M. Liu, P. Yang, P. Xu, C. Zhang, L. Li, C. Chang, N. Li, S. Wu, Y. Zhu, Q. Wang, B. Wen, L. Lin, Y. Wang, G. Zheng, L. Zhou, H. Lu, S. Liu, F. He and F. Zhong (2013). "Proteome atlas of human chromosome 8 and its multiple 8p deficiencies in tumorigenesis of the stomach, colon, and liver." J Proteome Res 12(1): 81-88.
10. Yu, H., J. Zhao, L. Lin, Y. Zhang, F. Zhong, Y. Liu, Y. Yu, H. Shen, M. Han, F. He and P. Yang (2012). "Proteomic study explores AGR2 as pro-metastatic protein in HCC." Mol Biosyst 8(10): 2710-2718.
专利:
1. 一种鉴定糖基化肽段的方法及装置，专利号：ZL 2009 1 0199086.4
2. 一种人肿瘤标志物-Tim17多肽及其用途，专利号：ZL 2009 1 0174168.3
软件著作权
1. 张扬，糖肽注释平台软件，2010.1，中国，2010SR00134