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钱茂祥

发布者：张弦发布时间：2021-07-25浏览次数：1132

钱茂祥（1981~），青年研究员，硕导

个人简介：

       中国科学院大学遗传学博士，美国圣述德儿童研究医院（St. Jude Children’s Research Hospital）博士后。现为复旦大学生物医学研究院课题组组长，复旦大学附属儿科医院兼聘教授，美国血液学会会员、美国癌症研究会会员，中华医学会儿科学分会血液青年学组委员。主要专注于儿童肿瘤及其他儿科疾病的遗传学、表观遗传学和功能基因组学研究，通过灵活地运用各种组学手段，深入的生物信息分析和数据挖掘，并有机结合下游基因功能研究，探索儿童肿瘤及其他儿科疾病的发病机制和预后风险因素。代表性成果：儿童白血病亚型的界定（Genome Res, 2017），儿童白血病遗传易感及致病基因的鉴定（Cancer Cell, 2018; JCO, 2018; Blood, 2019; Nat Commun., 2019; JNCI, 2019/2020），儿童肿瘤基因多种调控模式的研究(Blood, 2017)等。迄今已在Cancer Cell, Lancet Oncology, JCO, Genome Res., PNAS, Blood，Nature Commun.等国际高水平学术期刊发表SCI论文20余篇，曾获美国癌症研究会年度青年学者奖和美国血液学学会年度突出摘要奖等荣誉，入选上海高校特聘教授（东方学者）岗位计划(2019)，上海海外高层次人才引进计划(2020)，获得国家自然科学基金等多个项目支持。

联系方式：

电话：021-64932792

地址：上海市闵行区万源路399号8号楼911室

邮箱：mxqian@fudan.edu.cn

代表论文：

  1. Lee SHR#, Qian M#*, Yang W, Diedrich JD, Raetz E, Yang W, Dong Q, Devidas M, Pei D, Yeoh A, Cheng C, Pui CH, Evans WE, Mullighan CG, Hunger SP, Savic D, Relling MV, Loh ML, Yang JJ*. Genome-wide association study of susceptibility loci for TCF3-PBX1 acute lymphoblastic leukemia in children. J Natl Cancer Inst. 2020 Sep 3:djaa133. PMID: 32882024.

  2. Vijayakrishnan J#, Qian M#, Studd JB, Yang W, Kinnersley B, Law PJ, Broderick P, Raetz EA, Allan J, Pui CH, Vora A, Evans WE, Moorman A, Yeoh A, Yang W, Li C, Bartram CR, Mullighan CG, Zimmerman M, Hunger SP, Schrappe M, Relling MV, Stanulla M, Loh ML, Houlston RS*, Yang JJ*. Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk. Nat Commun. 2019 Nov 25;10(1):5348. PMID: 31767839.

  3. Qian M, Zhao X, Devidas M, Yang W, Gocho Y, Smith C, Gastier-Foster JM, Li Y, Xu H, Zhang S, Jeha S, Zhai X, Sanda T, Winter SS, Dunsmore KP, Raetz EA, Carroll WL, Winick NJ, Rabin KR, Zweidler-Mckay PA, Wood B, Pui CH, Evans WE, Hunger SP, Mullighan CG, Relling MV, Loh ML, Yang JJ*. Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children. J Natl Cancer Inst. 2019 Dec 1;111(12):1350-1357. PMID: 30938820.

  4. Qian M#, Xu H#, Perez-Andreu V, Roberts KG, Zhang H, Yang W, Zhang S, Zhao X, Smith C, Devidas M, Gastier-Foster JM, Raetz E, Larsen E, Burchard EG, Winick N, Bowman WP, Martin PL, Borowitz M, Wood B, Antillon-Klussmann F, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, and Yang JJ*. Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. Blood. 2019 Feb 14;133(7):724-729.  PMID: 30510082

  5. Churchman ML#, Qian M#, Te Kronnie G#, Zhang R, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Peters JL, Devidas M, Larsen E, Moore IM, Gu Z, Qu C, Yoshihara H, Porter SN, Pruett-Miller SM, Wu G, Raetz E, Martin PL, Bowman WP, Winick N, Mardis E, Fulton R, Stanulla M, Evans WE, Relling MV, Pui CH, Hunger SP, Loh ML, Handgretinger R, Nichols KE, Yang JJ*, Mullighan CG*. Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. Cancer Cell. 2018 May 14;33(5):937-948.e8. doi: 10.1016/j.ccell.2018.03.021. Epub 2018 Apr 19. PMID: 29681510.

  6. Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema NA, Zhang H, Moriyama T, Gastier-Foster JM, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ*. TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children. J Clin Oncol. 2018 Jan 4; JCO2017755215. PMID: 29300620.

  7. Li L#, Qian M#, Chen IH, Finkelstein D, Onar-Thomas A, Johnson M, Calabrese C, Bahrami A, López-Terrada DH, Yang JJ, Tao WA, Zhu L*. Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice. Am J Pathol. 2017 Dec 14; PMID: 29248454.

  8. Hu S#*, Qian M#, Zhang H#, Guo Y#, Yang J, Zhao X, He H, Lu J, Pan J, Chang M, Du G, Lin TN, Kham SK, Quah TC, Ariffin H, Tan AM, Cheng Y, Li C, Yeoh AE, Pui CH, Skanderup AJ, Yang JJ*. Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations. Blood. 2017 Jun 15;129(24):3264-3268. PMID: 28408461.

  9. Qian M#, Zhang H#, Kham SK, Liu S, Jiang C, Zhao X, Lu Y, Goodings C, Lin TN, Zhang R, Moriyama T, Yin Z, Li Z, Quah TC, Ariffin H, Tan AM, Shen S, Bhojwani D, Hu S, Chen S, Zheng H, Pui CH, Yeoh AE*, Yang JJ*. Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP. Genome Res. 2017 Feb;27(2):185-195. PMID: 27903646.