师资队伍

  • 副教授

杨慧蓉

发布者：金嘉怡发布时间：2021-07-22浏览次数：1390

杨慧蓉（博士/副研究员/硕士生导师）

出生：1981年8月

地址：东安路131号，明道楼711室，上海200032

电话：021-54237880

邮件：yanhr@fudan.edu.cn


主要工作经历

  • 2013.12～今 复旦大学生物医学研究院 副研究员

  • 2011.01～2012.01 阿拉巴马伯明翰大学 访问学者

  • 2008.01～2013.11 复旦大学生物医学研究院 助理研究员

主要学习经历

  • 2002.09～2008.01 复旦大学 生命科学学院 博士

  • 1998.09～2002.07 山西医科大学 药学院 学士

主持基金项目

  • 国家自然基金面上  国家自然科学基金  2018

  • 复旦大学卓学人才 复旦大学 2015

  • 浦江人才计划 上海市科委 2013

  • 国家自然基金青年 国家自然科学基金 2012

  • 上海市自然基金 上海市科委 2009

科学研究和论文成果：

       申请人近年来研究了与肿瘤相关的mTOR信号通路的重要蛋白质复合体mTORC1和mTORC2复合体的结构和功能；研究了表观遗传领域多个重要修饰酶的结构和功能，在结构生物学领域做出了不错的成果。总共发表论文20篇，包括Nature Communications（2篇），Cell Res (3篇)，Protein & cell (2篇), Mol Cell (2篇), Gene & Dev（2篇）等。获国家自然基金面上项目以及青年项目各一项，上海市自然基金项目一项以及获得了“上海市浦江人才计划”以及“复旦大学卓学计划”等。发表第一作者以及共同第一作者9篇，通讯以及共同通讯作者4篇，总共影响因子100分，发表论文详细如下：

# 共同第一作者，*共同通讯作者

  1. Chen, X., Liu, M., Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J., Yang, H.*, Xu, Y.*(2018) Cryo-EM structure of human mTOR complex 2. Cell research 28, 518-528

  2. Yang H, Chen X, Liu M, Xu, Y.* (2018) The structure of mTOR complexes at a glance. Precis Cancer Med 1:7

  3. Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M. Q., Wong, C. C., Wang, J., Xu, Y.*, and Wang, H. W*. (2016) 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1. Protein & cell 7, 878-887

  4. Fang J, Cheng J, Wang J, Zhang Q, Liu M, Gong R, Wang P, Zhang X, Feng Y, Lan W, Wong J, Yang H*, Cao C*, Xu, Y.* (2016) Hemi-methylated DNA Opens a Closed Conformation of UHRF1 to Facilitate Its Histone Recognition. Nat Commun. 7:11197.

  5. Cheng J, Li Z, Gong R, Fang J, Yang Y, Sun C, Yang H, Xu Y.* (2015)Molecular mechanism for the substrate recognition of USP7. Protein Cell. Nov;6(11):849-52.

  6. Cheng J#, Yang H#, Fang J, Ma L, Gong R, Wang P, Li Z, Xu Y.* (2015) Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun. 6:7023

  7. Yang Y, Yin X, Yang H, Xu, Y.* (2015) Histone Demethylase LSD2 Acts as an E3 Ubiquitin Ligase and Inhibits Cancer Cell Growth through Promoting Proteasomal Degradation of OGT. Molecular cell 58, 47-59

  8. Zhang, Y#., Yang, H#., Guo, X#., Rong, N., Song, Y., Xu, Y., Lan, W., Zhang, X., Liu, M., Xu, Y.*, and Cao, C.* (2014) The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein & cell 5, 837-850

  9. Zhang, Z.，Yang, H.，Wang, H*. (2014) The histone H2A Yang, Huirong deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage. J Biol Chem，11.21，289（47）：32883~32894

  10. Yang, H. #, Gong, R. #, and Xu, Y.* (2013) Control of cell growth: Rag GTPases in activation of TORC1, Cellular and molecular life sciences : CMLS70, 2873-2885.

  11. Xu, Y. #, Yang, H. #, Joo, HY. #, Yu JH, Smith AD IV, Schneider D, Chow LT, Renfrow M, Wang H#.(2013) Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression. Cell Cycle. 12(19):3219-27.

  12. Fang, R. #, Chen, F. #, Dong, Z., Hu, D., Barbera, A. J., Clark, E. A., Fang, J., Yang, Y., Mei, P., Rutenberg, M., Li, Z., Zhang, Y., Xu, Y., Yang, H., Wang, P., Simon, M. D., Zhou, Q., Li, J., Marynick, M. P., Li, X., Lu, H., Kaiser, U. B., Kingston, R. E., Xu, Y.*, and Shi, Y. G.* (2013) LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation, Molecular cell 49, 558-570.

  13. Chen, F. #, Yang, H. #, Dong, Z. #, Fang, J., Wang, P., Zhu, T., Gong, W., Fang, R., Shi, Y. G., Li, Z.*, and Xu, Y.* (2013) Structural insight into substrate recognition by histone demethylase LSD2/KDM1b, Cell research 23, 306-309.

  14. Gong, R. #, Li, L. #, Liu, Y. #, Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K. L., and Xu, Y.* (2011) Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation, Genes & development 25, 1668-1673.

  15. Jeong, B. R. #, Lin, Y. #, Joe, A., Guo, M., Korneli, C., Yang, H., Wang, P., Yu, M., Cerny, R. L., Staiger, D., Alfano, J. R.*, and Xu, Y. * (2011) Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity, The Journal of biological chemistry 286, 43272-43281.

  16. Guo, X.#, Xu, Y. #, Wang, P., Li, Z., Xu, Y.*, and Yang, H.* (2011) Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B, Acta crystallographica 67, 907-910.

  17. Li, Z. #, Zhao, B. #, Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K. L.*, and Xu, Y.* (2010) Structural insights into the YAP and TEAD complex, Genes & development 24, 235-240.

  18. Yang, H. #, Wang, Z. #, Shen, Y.#, Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D.*, Murchie, A. I.*, and Xu, Y.* (2010) Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus, Biochemistry 49, 6440-6450.

  19. Yang, H.#, Wang, P.#, Dong, Z.#, Li, X., Gong, R., Yang, Y., Li, Z., Xu, Y., and Xu, Y.* (2010) Crystallization and preliminary crystallographic analysis of nosiheptide-resistance methyltransferase from Streptomyces actuosus in complex with SAM, Acta crystallographica 66, 579-582.

  20. Lin, Y.#, Wang, P.#, Yang, H.*, and Xu, Y.* (2010) Crystallization and preliminary crystallographic analysis of the ADP-ribosyltransferase HopU1, Acta crystallographica 66, 932-934.