青年研究员 (副高五级)
复旦大学基础医学院
电话/Tel: +86-15800887478
邮箱/E-mail: zhouqt@fudan.edu.cn;
教育经历
2005.9 − 2009.6 高分子化学学士 中国科学技术大学高分子科学与工程系
2009.9 − 2015.7 高分子化学与物理博士 中国科学技术大学高分子科学与工程系 梁好均教授
2012.9-2014.9 联合培养博士生 哈佛大学化学与生物化学系Eugene Shakhnovich课题组
2019.9-2019.12 访问学者 比利时鲁汶大学癌症研究中心Diether Lambrechts课题组
工作经历
2015.7 − 2018.9 上海科技大学iHuman研究所博士后 赵素文课题组
2018.10 − 2020.6 上海科技大学iHuman研究所研究助理教授 赵素文课题组
2020.7 – 至今 复旦大学基础医学院医学系统生物学系青年研究员 王明伟教授研究团队
研究内容
生物大分子动态性质与调控的计算和实验研究
GPCR的结构药理学
计算机辅助药物设计
核酸适配体的筛选与设计
基金
2018.1-2020.12 国家自然科学基金青年项目，21704064，主持
2016.4-2018.7 中国博士后科学基金面上项目，2016M591721，主持
2020.1-2023.12 国家自然科学基金面上项目，31971178，参与
2012.1-2015.12 国家自然科学基金重点项目，91127046，参与
2011.1-2013.12 国家自然科学基金面上项目，51073145，参与
2009.1-2011.12 国家自然科学基金面上项目，20874094，参与
论文发表
近五年在Nature, Cell Research, ACS Chemical Biology, Chemical Science, Structure等杂志发表SCI论文25篇，其中第一，共同第一或通讯作者论文11篇，发表在Cell Research、Nature Communication、Elife、Cell Reports、Journal of Medical Chemistry、Journal of Physical Chemistry Letters、ACS Chemical Biology等期刊(其中IF>5论文8篇，IF>10论文3篇)。
1.Qingtong Zhou#, Dehua Yang#, Meng Wu, Yu Guo, Wangjing Guo, Li Zhong, Xiaoqing Cai, Antao Dai, Eugene Shakhnovich, Zhi-Jie Liu, Raymond C. Stevens, M. Madan Babu*, Ming-Wei Wang*, Suwen Zhao*, Common activation mechanism of class A GPCRs, Elife. 2019 Dec 19;8. pii: e50279.
2.Fulai Zhou#, Huibing Zhang#, Zhaotong Cong#, Li-Hua Zhao#, Qingtong Zhou#, Chunyou Mao, Xi Cheng, Dan-Dan Shen, Xiaoqing Cai, Cheng Ma, Yuzhe Wang, Antao Dai1, Yan Zhou, Wen Sun, Fenghui Zhao, Suwen Zhao, Hualiang Jiang, Yi Jiang, Dehua Yang*, H. Eric Xu*, Yan Zhang* & Ming-Wei Wang*, Structural basis for activation of the growth hormone-releasing hormone receptor. Nature Communication 2020, 11 (1), 5205.
3.Dehua Yang#, Qingtong Zhou#, Viktorija Labroska#, Shanshan Qin, Sanaz Darbalaei, Yiran Wu, Elita Yuliantie, Linshan Xie, Houchao Tao, Jianjun Cheng, Qing Liu, Suwen Zhao*, Wenqing Shui*,Yi Jiang* and Ming-Wei Wang*, G protein-coupled receptors: structure- and function-based drug discovery. Signal Transduction and Targeted Therapy, 2021,(6),7.
4.Wen Sun#, Li-Nan Chen#, Qingtong Zhou#, Li-Hua Zhao#, Dehua Yang#, Huibing Zhang, Zhaotong Cong, Dan-Dan Shen, Fenghui Zhao, Fulai Zhou, Xiaoqing Cai, Yan Chen, Yan Zhou, Sarina Gadgaard, Wijnand J. C. van der Velden, Suwen Zhao, Yi Jiang, Mette M. Rosenkilde, H. Eric Xu*, Yan Zhang* and Ming-Wei Wang*, A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, Cell Research, 2020, (30), 1098-1108.
5.Lu Qu#, Qingtong Zhou#, Yueming Xu, Yu Guo, Xiaoyu Chen, Deqiang Yao, Gye Won Han, Zhi-Jie Liu, Raymond C. Stevens, Guisheng Zhong,* Dong Wu,* and Suwen Zhao*, Structural Basis of the Diversity of Adrenergic Receptors, Cell Reports. 2019, 29 (10), 2929-2935.
6.Qingtong Zhou, Sun Xianbao, Xia Xiaole, Fan Zhou, Luo Zhaofeng, Zhao Suwen, Shakhnovich Eugene*, Haojun Liang *, Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space, Journal of Physical Chemistry Letters, 2017(8): 407~414.
7.Qingtong Zhou #, Xia Xiaole #, Zhaofeng Luo, Haojun Liang *, Eugene Shakhnovich *, Searching the Sequence Space for Potent Aptamers Using SELEX in Silico, Journal of Chemical Theory and Computation, 2015,11(12):5939~5946.
8.Liang Tan#, Qingtong Zhou#, Wenzhong Yan, Jian Sun, Alan P. Kozikowski, Suwen Zhao, Xi-Ping Huang*, and Jianjun Cheng*, Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands, Journal of Medicinal Chemistry, 2020, 63(9), 4579–4602.
9.Gaojie Song, Dehua Yang#, Yuxia Wang#, Chris de Graaf#, Qingtong Zhou, Shanshan Jiang, Kaiwen Liu, Xiaoqing Cai, Antao Dai, Guangyao Lin, Dongsheng Liu, Fan Wu, Yiran Wu, Suwen Zhao, Li Ye, Gye Won han, Jesper Lau, Beili Wu, Michael A. hanson, Zhi-Jie Liu*, Ming-Wei Wang* and Raymond C. Stevens*, Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Nature, 2017(546):312-315
10.Yan Lu#, Hongyue Liu#, Dehua Yang, Li Zhong, Ye Xin, Suwen Zhao, Ming-Wei Wang*, Qingtong Zhou* , and Wenqing Shui*, Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A2A Receptor Targeting the Sodium Ion Pocket. ACS Chemical Biology, 2021.