• Professors

Yan Hui-Xu



     XU Yanhui (1977-) Professor, Ph.D. of Tsinghua University, post-doctor of Princeton University. Dr. Xu currently serves as PI of Institute of Biomedical Sciences of Fudan University and a vice-director of The Biophysical Society of China. His research focuses on structural biology of epigenetic modification enzymes. His featured accomplishments are as follows: reveal the molecular mechanisms for catalysis, substrate recognition and regulation of enzymatic activity of enzymes that are involved in DNA methylation and histone methylation. He has been funded by two 973 and four NSFC Programs, and Ten Thousand Talents Program-Excellent Youths of the Organization Department of the Central Committee of the CPC, New Century Talent Support Program of Ministry of Education, Shanghai Excellent Principal Investigator, Pujiang Talent Program and Dawn Scholar Program in the total amount of RMB 12 million. In recent 5 years, he has published 16 corresponding-author papers in Cell,Mol Cell,Proc Natl Acad Sci,Genes & Dev,Cell Research,J Biol Chem and etc. 



1. Hu, L.#, Li, Z. #, Cheng, J. #, Rao, Q., Gong, W., Liu, M., Shi, YG., Zhu, J., Wang, P. and Xu, Y. * Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation, Cell  155, 1545-1555, 2013
2. Fang, R. #, Chen, F. #, Dong, Z., Hu, D., Barbera, A. J., Clark, E. A., Fang, J., Yang, Y., Mei, P., Rutenberg, M., Li, Z., Zhang, Y., Xu, Y., Yang, H., Wang, P., Simon, M. D., Zhou, Q., Li, J., Marynick, M. P., Li, X., Lu, H., Kaiser, U. B., Kingston, R. E., Xu, Y.*, and Shi, Y. G.* LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation, Molecular cell 49, 558-570, 2013
3. Chen, F. #, Yang, H. #, Dong, Z. #, Fang, J., Wang, P., Zhu, T., Gong, W., Fang, R., Shi, Y. G., Li, Z.*, and Xu, Y.* Structural insight into substrate recognition by histone demethylase LSD2/KDM1b, Cell research 23, 306-309, 2013
4. Cheng, J., Yang, Y., Fang, J., Xiao, J., Zhu, T., Chen, F., Wang, P., Li, Z., Yang, H., and Xu, Y.*  Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein, The Journal of biological chemistry 288, 1329-1339, 2013
5. Ma, H. #, Chen, H. #, Guo, X. #, Wang, Z., Sowa, M. E., Zheng, L., Hu, S., Zeng, P., Guo, R., Diao, J., Lan, F., Harper, J. W., Shi, Y. G., Xu, Y.*, and Shi, Y.* M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability, Proceedings of the National Academy of Sciences of the United States of America 109, 4828-4833, 2012
6. Yang, Y. #, Hu, L. #, Wang, P. #, Hou, H., Lin, Y., Liu, Y., Li, Z., Gong, R., Feng, X., Zhou, L., Zhang, W., Dong, Y., Yang, H., Lin, H., Wang, Y., Chen, C. D.*, and Xu, Y.* Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans, Cell research 20, 886-898, 2010
7. Hu, L. #, Li, Z. #, Wang, P., Lin, Y., and Xu, Y.*  Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2, Cell research. 21(9):1374-8, 2011
8. Gong, R. #, Li, L. #, Liu, Y. #, Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K. L., and Xu, Y.* Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation, Genes & development 25, 1668-1673, 2011
9. Li, Z. #, Zhao, B. #, Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K. L.*, and Xu, Y.* Structural insights into the YAP and TEAD complex, Genes & development 24, 235-240, 2010