WEN Wenyu (1981-) professor. Doctor and post-doctor of Hong Kong University of Science and Technology, currently serves as a member of the Discipline Committee of Biological Magnetic Resonance, The Biophysical Society of China. Wen’s research focuses on the structural biology of neuronal differentiation and signaling, and her featured accomplishments are as follows: systemically studied the molecular mechanisms of asymmetric division of neural stem cells; revealed the structural basis of the dynamic visual scaffold INAD PDZ5 in actively participating in signaling processes by conformation-coupled redox potential modulation upon light stimulation. She has been funded by 9 projects of 973 Program, NSFC, New Century Talent Support Program of Ministry of Education and Shanghai Rising-star Program in the total amount of RMB 6.57 million, and published 20 articles in international peer-reviewed journals such as Cell, Mol. Cell, and EMBO J.
Publications:
1. Pan, Z., Shang, Y., Jia, M., Zhang, L., Xia, C., Zhang, M., Wang, W.*, and Wen, W.* “Structural and biochemical characterization of the interaction between LGN and Frmpd1” J. Mol. Biol. (2013) 425, 1039-1049.
2. Liu, X., Li, F., Pan, Z., Wang, W.*, and Wen, W.* “Solution structure of the SH3 domain of DOCK180” Proteins (2013) 81, 906-910.
3. Zhu, J., Shang, Y., Xia, C., Wang, W., Wen, W.*, and Zhang, M.* “Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-protein-binding Modules” EMBO J. (2011) 30, 4986-4997.
4. Zhu, J.#, Wen, W.#, Zheng, Z., Shang, Y., Wei, Z., Xiao, Z., Pan, Z., Du, Q., Wang, W., and Zhang, M. “LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gаi/LGN/NuMA pathways” Mol. Cell (2011) 43, 418-431. (#: co-first authors)
5. Liu, W.#, Wen, W.#, Wei, Z., Yu, J., Ye, F., Liu, C.-H., Hardie, R.C., and Zhang, M. “The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye” Cell (2011) 145, 1088-1101. (#: co-first authors) (Cover article)
6. Wen, W., Yu, J., Pan, L., Wei, Z., Weng, J., Wang, W., Ong, Y.S., Hoai, T.T.T., Hong, W., and Zhang, M. “Lipid-induced conformational switch controls fusion activity of longin domain SNARE Ykt6” Mol. Cell (2010) 37, 383-395.