Yang Huirong (1981-) associate professor. Doctor of Fudan University. Dr. Yang focuses on mechanisms for substrate recognition and regulation of epigenetic enzymes as well as modification regulation mechanism of enzyme itself in field. Representative achievements: For the first time discover dual substrate binding sites of histone demethylase LSD2, providing a platform for design of specific inhibitors of histone demethylase. She has been funded by NSFC program, a project sponsored by Shanghai Nature Fund and supported by Shanghai Pujiang Talent Program with research funds of RMB 530 thousand; publish 13 SCI indexed papers in Cell Research, Cell Cycle，Mol Cell, etc.
Publications:
1. Chen, F.*, Yang, H.*, Dong, Z.*, Fang. J, Wang P., Zhu T., Gong W., Xu Y #. Structural Insight into Substrate Recognition by Histone Demethylase LSD2/KDM1b. Cell Research, 2013, 23(2):306-9.
2. Xu, Y. *, Yang, H. *, Joo, HY. *, Yu JH, Smith AD IV, Schneider D, Chow LT, Renfrow M, Wang H#. Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression. Cell Cycle. 2013 12(19):3219-27.
3 .Yang, H.*, Gong. R.*, Xu Y #. Control of cell growth: Rag GTPases in activation of TORC1. Cellular and molecular life sciences, 2013, 70(16):2873-85.
4. Yang, H., Wang, Z., Shen, Y., Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z.,Yang, Y., Chen, D. #, Murchie, A. # and Xu, Y. # Crystal Structure of the NosiheptideResistance Methyltransferase of Streptomyces actuosus. Biochemistry. 2010, 49(30): 6440-50.
5. Lin Y, Wang P, Yang, H., # Xu Y#. Crystallization and preliminary crystallographicanalysis of the ADP-ribosyltransferase HopU1. Acta Crystallogr Sect F StructBiol Cryst Commun. 2010, 66 (Pt 8):932-4.
6. Yang, H., Wang P, Dong Z, Li X, Gong R, Yang Y, Li Z, Xu Y, Xu Y. Crystallizationand preliminary crystallographic analysis of nosiheptide- resistance methyltransferase from Streptomyces actuosus in complex with SAM. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010, 66 (Pt 5):579-82.
7. Guo, X., Xu, Y., Wang, P., Li, Z., Xu, Y., Yang, H #. Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B. Acta Crystallogr Sect F StructBiol Cryst Commun. 2011, 67 (Pt 8):907-10.
8. Fang, R., Chen, F., Dong, Z., Hu, D., Barbera, AJ., Clark, EA., Fang, J., Yang, Y., Mei, P., Rutenberg, M., Li, Z., Zhang, Y., Xu, Y., Yang, H., Wang, P., Simon, MD., Zhou, Q., Li, J., Marynick, MP., Li, X., Lu, H., Kaiser, UB., Kingston, RE., Xu, Y.#, Shi, YG.#. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Mol Cell. 2013, 49(3):558-70.
9. Jeong, BR., Lin, Y., Joe, A., Guo, M., Korneli, C., Yang, H., Wang, P., Yu, M., Cerny, RL., Staiger, D., Alfano, JR., Xu, Y. Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. J Biol Chem. 2011, 286(50):43272-81.
10. Gong, R., Li, L., Liu, Y., Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K., Xu, Y. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes Dev. 2011, 25(16):1668-73.