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Hua Li-Shen

发布者:系统管理员发布时间:2021-07-25浏览次数:122

 

      SHEN huali(1979~), associate professor, Ph.D.of Fudan University. Dr. Shen focuses on disease proteomics including genome-wide proteomes of related specimens, posttranslational modification and the corresponding biological function studies, another research interest of her is the lipid metabolism and signal pathway research. Representative achievements: the leader of a NSFC project--secretomics of metastasis of hepatocellular carcinoma, the leader of an 863 project--development of electrospray ionization time-of-flight mass spectrometry; serve as a principal member in many 973 projects; in charge of 6 research projects with funds of RMB 4 million; publish over 10 papers in journals including Genes&Dev., J. Proteome Rstudiesmics with a total impact factor higher than 60.

 

Publications:

1. Huanhu Zhu, Huali Shen, Aileen K Sewell, Marina Kniazeva, and Min Han*. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. eLife. 2013; 2: e00429.
2. Yanyan Yu, Xiuwen Pan, Ying Ding, Xiaohui Liu, Hailin Tang, Chengpin Shen, Huali Shen* and Pengyuan Yang*. An iTRAQ based quantitative proteomic strategy to explore novel secreted proteins in metastatic hepatocellular carcinoma cell lines.  Analyst, 2013, Advance Article, DOI: 10.1039/C3AN00517H
3. Chengpin Shen, Yanyan Yu, Hong Li, Guoquan Yan, Mingqi Liu, Huali Shen*, Pengyuan Yang*. Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network. Proteomics. 2012 Jun; 12(12):1917-27.
4. Songfeng Wu, Ning Li, Jie Ma, Huali Shen, Pengyuan Yang *, and Fuchu He *, et. al. First Proteomic Exploration of Protein-Encoding Genes on Chromosome 1 in Human Liver, Stomach, and Colon. J proteome res, 2013, 12, 67-80. IF 5.48
5. Chengpin Shen, Yanyan Yu, Hong Li, Guoquan Yan, Mingqi Liu, Huali Shen*, Pengyuan Yang*. Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network. Proteomics. 2012 Jun; 12(12):1917-27.
6. Marina Kniazeva, Huali Shen, Tetyana Euler, Chen Wang, and Min Han. Regulation of maternal phospholipid composition and IP3-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Genes Dev. March 15, 2012 26: 554-566.
7. Yanyan Yu, Huali Shen, Hongxiu Yu, Pengyuan Yang, et. al. Systematic proteomic analysis of human Hepatocellular carcinoma cells reveals molecular pathways and networks involved in metastasis. Mol Biosyst. 2011 Jun;7(6):1908-16. 
8. Yanyan Yu, Mingqi Liu, Huali Shen*, Pengyuan Yang*, et. al. Hydrazide-functionalized Magnetic Microspheres for the Selective Enrichment of Digested Tryptophan-containing Peptides in Serum. Talanta, 2011, 85(2):1001–1006 
9. Huali Shen, Gang Cheng, Huizhi Fan, Pengyuan Yang, et. al. Expressed proteome analysis of human hepatocellular carcinoma in nude mice (LCI-D20) with high metastasis potential. Proteomics, 6(2), 528-537 
10. Chinese Human Liver Proteome Profiling Consortium. First Insight into the Human Liver Proteome from PROTEOMESKY-LIVER Hu 1.0, a Publicly Available Database. J proteome res, 2010, 9 (1), 79-94