Zhang Wen (1971-) associate professor. Master of Huazhong University of Science and Technology, research assistant in Institute of Biochemistry of CAS and UC Berkeley. Mr. Zhang focuses on structural and functional studies of ribosome including structural dynamics and mechanism for antibiotics resistance based on structural biology and bioinformatics. Representative achievements: solved the first structure of dynamic intermediate state at high-resolution during translation elongation; got two research grants from 973 Program and NSFC and the total amount is over RMB 1 million; applied for an international patent and got approved; publish papers in Science, Nature Struct Mol Biol, etc. as the first author which have been cited over 1200 times.
Publications:
1. Y Ruan, L Sun, Y Hao, L Wang, J Xu, W Zhang,et al. Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma. J Clin Invest. 2012; 122:2554–2566 (initial data for crystallography. )
2. Beatriz LS, Dunkle J, Dorota L, Zhang W, Fernandes P, Cate J, Alexander M. Binding and action of CEM-101, a new fluor oketolide antibiotic that inhibits protein synthesis. Antimicrobial Agents and Chemotherapy. 2010, Vol. 54: 4961-4970
3. Zhang W*, Dunkle J, Cate J. Structures of the ribosome in intermediate states of ratcheting. Science 325, 1014 (2009). True milestone work comments by Liljas Anders. Leaps in Translational Elongation. Science 326, 677-678
4. Pai RD*, Zhang W*, Schuwirth BS, Hirokawa G, Kaji H, Kaji A, Cate JHD. Structural Insights into Ribosome Recycling Factor Interactions with the 70S Ribosome. J Mol Biol. 2008 7; 376(5):1334-47. *Equal contribution
5. Borovinskaya MA*, Pai RD*, Zhang W*, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nature Struct Mol Biol. 2007 Aug; 14(8):727-32. (Important Progress cited by APS 2007 annual report ) *Equal contribution
6. Berk V, Zhang W, Pai RD, Cate JH. Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci USA. 2006 Oct 24; 103(43): 15830-4
7. Schuwirth BS, Borovinskaya MA, Hau CW, Zhang W, Sanjurjo AV, Holton JM , Cate JHD, Structures of the bacterial ribosome at 3.5 Å resolution. Science 2005 4; 310: 827-34
8. Anton VS, Ridgeway W, Seymaner V, Zhang W, Santoso S, Yu K，Cate JHD. X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli. Proc Natl Acad Sci USA 100(15) P8682