YU Hongxiu (1976-) associate professor, Ph.D. of Fudan University. Dr. Yu presently serves as the deputy director of Medical Systems Biology Department. Yu’s research focuses on disease proteomics and posttranslational modification functions. Representative achievements: identification the key proteins in metastasis of hepatocellular carcinoma and clarify the function of glycosylation to key proteins in metastasis such as KAI1, AGR and HDGF. She has been funded by 1 project of NCFC ,2 “973”in the total amount of RMB 3 million，and published 22 articles in international peer-reviewed journals including Carcinogenesis ,Circulation Research et al in the past three years, obtained 2 patents.
Publications:
1. L Lin#, MM Han#, F Wang, LL Xu, HX Yu*, PY Yang*.Chemokine receptor CXCR7 promotes hepatocellular carcinoma cell growth and metastasis in vitro and in vivo via activating MAPK pathway. Cell Death and Disease, 2014 (In press). (Co-responding author)
2. H Wang#, H Li#, W Zhang, LM Wei1, HX Yu*, and PY Yang*. Multiplex Profiling of Glycoproteins Using a Novel Bead-based Lectin Array. Proteomics 14:78-86, 2013. (Co-responding author)
3. Y Yang#, CJ Wang#, PZ Zhang#, K Gao, DJ Wang, HX Yu, T Zhang, SR Jiang, SY Hexige, ZH Hong, Akira Yasui, Jun O. Liu, HJ Huang, L Yu*. Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis. Journal of Biological Chemistry 288(1):529-39,2013.
4. J Mao#, HX Yu#, CJ Wang#, LH Sun, W Jiang, PZ Zhang,QY Xiao, HX Saiyin, JD Zhu, TY Chen, Lewis R. Roberts, HJ Huang, L Yu*. Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas. Carcigenosis 33(12):2568-77, 2012. (Co-first author)
5. HX Yu#, J Zhao#, L Lin, Y Zhang, F Zhong, YK Liu, YY Yu, HL Shen, MM Han, FC He*, PY Yang*. Proteomic study explores AGR2 as pro-metastatic protein in HCC. Molecular BioSystems, 8(10):2710-2718, 2012.
6. H Wang#, W Zhang, J Zhao, L Zhang, MQ Liu, GQ Y, J Yao, HX Yu*, and PY Yang*. N-Glycosylation Pattern of Recombinant Human CD82 (KAI1), a Tumor-Associated Membrane Protein. Journal of Proteomics, 75 (4): 1375 - 85, 2012. (Co-responding author)
7. L Li# , H Gong#, HX Yu, XH Liu, QP Liu, GQ Yan, Y Zhang, HJ Lu, YZ Zou*, PY Yang*. Knockdown of nucleosome assembly protein 1-like 1 promotes dimethyl sulfoxide-induced differentiation of P19CL6 cells into cardiomyocytes. Journal of Cellular Biochemistry 113(12):3788-96, 2012.
8. L Edward#, D Wang#, J Zhang, HX Yu, Maggie Lam, XB Liang, CG Zong, Tae-Young Kim, PP Ping*. Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria. Circulation research, 110(9):1174-8, 2012.
9. J Zhao#, HX Yu#, F Zhong, Lin L, Jun T, LL Cai, YM Chen, F Zhong, CZ Lin, FC He*, PY Yang*. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Journal of Proteomics, 75(2):588-602, 2011. (Co-first author)
10. YY Yu#, HL Shen#, HX Yu#, F Zhong, Y Zhang,C Zhang, J Zhao, H Li, J Chen, YK Liu* and PY Yang*. Systematic proteomic analysis of human hepotacellular carcinoma cells reveals molecular pathways and networks involved in metastasis. Molecular BioSystems, 7, 1908–1916, 2011. (Co-first author)