代表性论文 |
Min, Q.*, Meng, X.*, Zhou, Q.*, Wang, Y., Li, Y., Lai, N., Xiong, E., Wang, W., Yasuda, S., Yu, M., Zhang, H., Sun, J., Wang, X.#, Wang, J.-Y.# RAG1 splicing mutation causes enhanced B-cell differentiation and autoantibody production. JCI Insight 6: e148887 (2021). Lai, N, Liu, L., Lin, L., Cui, C., Wang, Y., Min, Q., Xiong, E., Wang, W., Ying, W., Zhou, Q., Hou, J., Sun, J., Wang, J.-Y., and Wang, X. Effective and safe treatment of a novel IL2RA deficiency with rapamycin. J. Allergy Clin. Immunol. Pract., 8(3): 1132-1135e4 (2020) Hong, R., Lai, N., Xiong, E., Ouchida, R., Sun, J., Zhou, Y., Tang, Y., Hikida, M., Tsubata, T., Tagawa, M., Wang, Y. and Wang, J.-Y. Distinct roles of BCNP1 in B cell development and activation. Int. Immunol., in press (2019). Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. and Wang, J.-Y. MZB1 promotes the secretion of J chain-containing dimeric IgA and is critical for the suppression of gut inflammation. Proc. Natl. Acad. Sci. USA 116: 13480-13489 (2019).(Cover story) Hong, R., Lai, N., Ouchida, R., Xiong, E., Zhou, Y., Hikida, M., Tsubata, T., Wang Y.Q. and Wang, J.-Y. The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis. Eur. J. Immunol. 49: 911-917 (2019). (Cover story) Liu, J., Wang, Y., Xiong, E., Hong, R., Ohno, H. and Wang, J.-Y. Role of the IgM Fc receptor in immunity and tolerance. Front. Immunol. 10: 529 (2019). Li, S., Liu, J., Min, Q., Ikawa, T., Yasuda, S., Yang, Y., Wang, Y.-Q., Tsubata, T., Zhao, Y. and Wang, J.-Y. Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development. Int. Immunol. 30: 311-318 (2018). Liu, J., Zhu, H., Qian, J., Xiong, E., Zhang, L., Chu, Y., Kubagawa, H., Tsubata, T. and Wang, J.-Y. FcµR promotes the survival and activation of marginal zone B cells and protects mice against bacterial sepsis. Frontiers in Immunol. 9: 160 (2018). Liu, J., Xiong, E., Zhu, H., Mori, H., Yasuda, S., Kinoshita, K., Tsubata, T. and Wang, J.-Y. Efficient induction of Ig gene hypermutation in ex vivo-activated primary B cells. J. Immunol.199: 3023-3030 (2017). (Featured article) Li, Y., Takahashi, Y., Fujii, S., Zhou, Y., Hong, R., Suzuki, A., Tsubata, T., Hase, K., Wang, J.-Y. EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity.Nature Commun. 7: 10836 (2016). Liu, X., Jiang, X., Liu, R., Wang, L., Qian, T., Zheng, Y., Deng, Y., Huang, E., Xu, F., Wang, J.-Y. and Chu, Y. B cells expressing CD11b effectively inhibit CD4+ T cell responses and ameliorate experimental autoimmune hepatitis. Hepatology 62: 1563-1575 (2015). Wang, L., Ray, A., Jiang, X., Wang, J.-Y., Basu, S., Liu, X., Qian, T., He, R., Dittel, B.N. and Chu, Y. T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis.Mucosal Immunol., 8: 1297-1312 (2015). Ouchida, R., Lu, Q., Liu, J., Li, Y., Chu. Y., Tsubata, T. and Wang, J.-Y.FcμR interacts and cooperates with the B cell receptor to promote B cell survival.J. Immunol. 194: 3096-3101 (2015). Kawai, Y., Ouchida, R., Yamasaki, S., Dragone, L., Tsubata, T. and Wang, J.-Y. LAPTM5 promotes lysosomal degradation of intracellular but not the cell surface CD3ξ. Immunol. Cell Biol. 92: 527-534 (2014). Ouchida, R., Mori, H., Ohno, H. and Wang, J.-Y. FcμR (Toso/Faim3) is not an inhibitor of Fas-mediated cell death in mouse T and B cells. Blood121: 2368-2370 (2013). Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H. and Wang, J.-Y. Critical role of the IgM Fc receptor in IgM homeostasis, B cell survival and humoral immune responses. Proc. Natl. Acad. Sci. USA 109: E2699-2706 (2012). (Faculty of 1000) Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H. and Wang, J.-Y. Critical role of the IgM Fc receptor in IgM homeostasis, B cell survival and humoral immune responses. Proc. Natl. Acad. Sci. USA 109: 15989-15990. (Author Summary) (2012). Kawano, Y., Ouchida, R., Wang, J.-Y., Yoshikawa, S., Yamamoto, M., Kitamura, D. and Karasuyama, H. Li, Y., Li, S., Hoshino, M., Ishikawa, R., Kajiwara, C., Gao, X., Zhao, Y., Ishido, S., Udono, H. and Wang, J.-Y. HSP90α deficiency does not affect Ig gene hypermutation and class switch but causes enhanced MHC class II antigen presentation. Int. Immunol. 24: 751-758 (2012). Kano, C., Hanaoka, F. and Wang, J.-Y. Analysis of mice deficient in both REV1 catalytic activity and POLH reveals an unexpected role for POLH in the generation of C to G and G to C transversions during Ig gene hypermutation. Int. Immunol. 24: 169-174 (2012). Imai, T., Kato, Y., Kajiwara, C., Mizukami, S., Ishige, I., Ichiyanagi, T., Hikida, M., Wang, J.-Y. and Udono, H. Hsp90 contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc. Natl. Acad. Sci. USA, 108: 16363-16368 (2011). Ouchida, R., Kurosaki, T. and Wang, J.-Y. A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface BCR levels and B cell activation. J. Immunol. 185: 294-301 (2010). (Featured in “In This Issue”) Shima, H., Takatsu, H., Fukuda, S., Ohmae, M., Hase, K., Kubagawa, H., Wang, J.-Y., and Ohno, H. Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int. Immunol. (2010). Kubagawa, H., Oka, S., Kubagawa, Y., Torii, I., Takayama, E., Kang, D.W., Gartland, G.L., Bertoli, L.F., Mori, H., Takatsu, H., Kitamura, T., Ohno, H. and Wang, J.-Y. Identity of the elusive IgM Fc receptor (FcµR) in humans. J. Exp. Med. 206: 2779-2793 (2009). Mori, H., Ouchida, R., Hijikata, A., Kitamura, H., Ohara, O., Li, Y., Gao, X., Yasui, A., Lloyd, R.S., Wang, J.-Y. Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion. DNA Repair 8: 1328-1332 (2009). (Featured article) Masuda, K., Ouchida, R., Li, Y., Gao, X., Mori, H. and Wang, J.-Y. A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during immunoglobulin gene hypermutation. J. Immunol.1846-1850 Ukai, A., Ishimaru, K., Ouchida, R., Mori, H., Kano, C., Moritan, T. and Wang, J.-Y. Induction of A:T mutations is dependent on cellular environment but independent of mutation frequency and target gene location. J. Immunol. 181: 7835-7842 (2008). Masuda, K., Ouchida, R., Yokoi, M., Hanaoka, F., Azuma, T. and Wang, J.-Y. DNA polymerase η is a limiting factor for A:T mutations in Ig genes and contributes to the antibody affinity maturation. Eur. J. Immunol. 38: 2796-2805 (2008). (Featured article) Ehrhardt, G., Hijikata, A., Kitamura, H., Ohara, O., Wang, J.-Y., Vaughan, W.P. and Cooper, M.D. Distinctive gene expression profiles of memory B cell subpopulations in humans. J. Exp. Med. 205: 1807-1817 (2008). Ouchida, R., Yamasaki, S., Hikida, M., Masuda, K., Kawamura, K., Wada, A., Mochizuki, S., Tagawa, M., Sakamoto, A., Hatano, M., Tokuhisa, T., Koseki, H., Saito, T., Kurosaki, T. and Wang, J.-Y. A Lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3ζ degradation. Immunity 29: 33-43 (2008).
|