姓名：王作云
职称：青年研究员,博士生导师
电话：021-54237698
电子邮箱：wangzuoyun@fudan.edu.cn
办公地点：上海市徐汇区东安路131号东1号楼351
个人主页/课题组网页：无。
简介：
王作云，复旦大学基础医学院青年研究员；2013年中科院上海生化与细胞所获得博士学位；2021年3月加入复旦大学基础医学院；主要从事细胞内外信号异常与疾病发生之间机制研究。迄今已在 STTT、Science Advances、EMBO Journal、Cancer Letters、Cell Proliferation等杂志发表研究论文30余篇，目前论文被引用800余次。先后获得中国博士后、上海市博士后、上海市面上、国家自然科学基金青年项目、面上项目（2项在研）以及科技部重大研发等项目资助。
研究方向：
实验室主要围绕细胞内外信号转导异常与疾病发生之间的关系展开，通过揭示器官发育、组织损伤修复再生、肿瘤发生的细胞基础和分子机制为相关疾病及肿瘤诊疗提供新思路。
1. 利用生化、分子与细胞生物学等研究手段，解析重要信号通路在细胞增殖、细胞分化、细胞凋亡过程中的功能及分子机制。
2. 利用小鼠的组织损伤修复以及肿瘤模型，结合人体临床样本分析，揭示Hippo等信号网络在疾病以及肿瘤发生中的功能及作用机理。
3. 利用细胞和小鼠肿瘤模型筛选抗肿瘤及免疫相关的小分子化合物。
荣誉与获奖：
1. 2023年度 中国转化医学第八届青年优秀论文一等奖
2. 2021年度上海市细胞生物学学会优秀青年学者奖
3. 2020年度 Sanofi-SIBS 2020 Yong Faculty Award
4. 2018年度Youth Innovation Promotion Association Award
5. 2014年度中国科学院上海生科院优秀青年人才奖
6. 2010年度中国生物化学与分子生物学学会青年科学家论坛奖
发表论文：(# Co-first author; * Co-corresponding author)
1. Ying Lu#, Lanfang Li#, Hanting Yang, Bin Li, Zuoyun Wang*. DNA bridging of FOXP3 ladder-like multimer: Unveiling a novel transcriptional regulation paradigm. The Innovation, 2024 Feb 29;5(3):100598.
2. Jingjing Zhou#, Lanfang Li, Baojin Wu, Zhen Feng, Ying Lu*, Zuoyun Wang*. MST1/2: important regulators of Hippo pathway in immune system associated diseases. Cancer Letters, 2024 Apr 10:587:216736.
3. Zhengda Li #, Junqing Lin #, Jing Wu, Jinlong Suo*, Zuoyun Wang*. The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging. Cell Proliferation, 2024 May 3:e13652. doi: 10.1111/cpr.13652.
4. Fangzhen Chen#, Wulei Hou#, Xiangtian Yu#, Jing Wu, Zhengda Li, Jietian Xu1, Zimu Deng，Gaobin Chen, Bo Liu, Xiaoxing Yin, Wei Yu, Lei Zhang, Guoliang Xu, Hongbin Ji, Chunmin Liang*, Zuoyun Wang*. CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability. Signal Transduction and Targeted Therapy,2023 Sep 12;8(1):343.
5. Jinlong Suo#, Xue Feng#, Jiayi Li, Jinghui Wang, Zuoyun Wang*, Lei Zhang*, Weiguo Zou*. VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcriptions. Science Advances, 2020 23; 6 (43): eaba4147.
6. Wei Yu#, Xueyan Ma#, Jinjin Xu, Zhaoliang Fei, Xue Feng, Xiaodong Wang, Kuo Liu, Jinhui Li, Guizhong Cui, Guangdun Peng, Hongbin Ji, Jinsong Li, Naihe Jing, Hai Song, Zhiqiang Lin, Yun Zhao, Zuoyun Wang*, Bin Zhou* and Lei Zhang*. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genetics.2019, 15(2): e1007977.
7. Xue Feng#, Zuoyun Wang#, Fei Wang#, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He,Wenxiang Zhang, Sheng Li, Wenjun Yang, Lili Han, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu*, and Lei Zhang*. Dual function of VGLL4 in muscle regeneration. EMBO Journal. 2019, 38(17):e101051.
8. Zuoyun Wang, Zhaoyuan Fang, Gaobin Chen, Bo Liu, Jinjin Xu, Fei Li, Fuming Li, Hongyan Liu, Haoen Zhang, Yihua Sun, Gang Tian, Haiquan Chen, Guoliang Xu, Lei Zhang, Liang Hu, Hongbin Ji *. CBX4 exerts oncogenic properties in lung cancer through Wnt signalling pathway. Neoplasia, 2021; 23 (2):222-233.
9. Zuoyun Wang #, Yihua Sun#, Bin Gao#, Yi Lu, Rong Fang, Yijun Gao, Tian Xiao, Xin-Yuan Liu, William Pao, Yun Zhao*, Haiquan Chen*, Hongbin Ji*. Two co-existed germline mutations P53V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome. Cancer Letters. 2014, 342 (1):36-42.
10. Zuoyun Wang#, Yan Feng#, Nabeel Bardessy, Kwok-kin Wong, Xin-Yuan Liu*, Hongbin Ji*. Temporal dissection of K-rasG12D Mutant in vitro and in vivo using a regulatable K-rasG12D mouse allele. PLoS One. 2012, 7, e37308.
