姓名：尤琳雅
职称：副教授
电话：021-54237027
电子邮箱：lyyou@fudan.edu.cn
办公地点：上海市徐汇区东安路131号东9号楼204
个人主页/课题组网页 建设中
简介：
尤琳雅，复旦大学基础医学院人体解剖与组织胚胎学系副教授。2015年于麦吉尔大学医学院实验医学系获博士学位，随后于斯坦福大学医学院神经外科系进行博士后训练，2017年2月加入复旦大学，多年探究人类语言的生物学基础及其功能障碍病因学。迄今在J Clin Invest, Brain, Transl Psychiatry,Clin Transl Med, iScience等国际期刊上发表论文及综述33篇,中文期刊14篇，引用1046（Google Scholar 2026.02.27）。主持国自然面上项目1项、上海市科委外专项目2项、复旦卓学人才项目1项、横向项目2项，并作为课题骨干承担国家科技部脑计划1项、重点研发计划1项和上海市基础特区计划1项。承担9门本科生和5门研究生课程授课，年课时数200+。作为主讲教师获复旦大学教学成果奖和多项上海市级课程荣誉。参编5部医学教材，指导学生多次获国家级大学生创新训练计划项目(x2)、上海市优秀毕业生(x1)、复旦大学优秀毕业生(x2)、“卓博计划”(x3)、FDUROP(x5)等。担任高教社Human Brain杂志副主编、中国解剖学会青年工作委员会委员、中国解剖学会人脑库研究分会委员。
研究方向：
1. 语言侧化的分子机制研究
1. 发声调控的分子机制研究
2. 语言障碍相关疾病的靶点机制研究
讲授课程：
本科生：《组织胚胎学B》《Histology and Embryology》《医学形态学基础》《神经系统疾病基础》《呼吸系统疾病基础》《内分泌生殖系统疾病基础》《泌尿系统疾病基础》《医学生综合素养》《学术英语（医学）》
研究生：《分子神经解剖学》（课程负责人）、《发育神经生物学（一）》（课程负责人）、《组织学进展》、《组织学与影像结合的科研与临床》、《感知运动的解剖学概论》
获得人才项目和奖励：
2024，中国-新西兰科学家交流计划入选者，中国科技部与新西兰商业、创新与就业部
2023，外国专家青年人才，上海市科学技术委员会（上海市外国专家局）
2022，外国专家青年人才，上海市科学技术委员会（上海市外国专家局）
2020-2022，复旦大学“卓越2025”卓学优秀人才，复旦大学
2015 Productivity Award，麦吉尔大学
2014 Graduate Excellence Award, 麦吉尔大学
2012-2013 Faculty of Medicine Internal Studentship, 麦吉尔大学
2011 MICRTP Ph.D. studentship, 麦吉尔大学
2010 Entrance fellowship, 麦吉尔大学
发表论文（以第一或通讯作者发表）：
1. Wang Z#, Chen Y#, Feng Y#, Zu G#, Wang W, Liang L, Liu X, Mei Y, Yang J, Wang T, Liu M, Jiang L, Snell RG, Highet B, Curtis M, Chen L, Li S, Wu J, Zhang M*, Li W*, Wei GH*, You L*. Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production. iScience 2026, 29(2):114692.
2. Liu X#, Zhou X#, Meng R#, Chen Y, Chen Y, Highet B, Curtis M, Hirt B, Yu S*, Zhou J*, You L*. Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders. Clin Trans Discov 2026 online now. DOI 10.1002/ctd2.70128.
3. Wu J#*, Wang Z#, Li F#, Bu S#, Sun L#, Zheng C, Bai Z, Yang L, Gong F, Chen J, Huang Y, Li W, Yan G, Xian W, Yang J, Wu S, Zhu K, Fan W, Liu Q, Zhou G, Wei GH, Li W, Yan J, Cheng J, Snell RG, Curtis M, Jia T, Yuan B*, He Y*, Zhang W*, You L*. Molecular architecture of language-related cortical areas revealed by integrative proteomic and connectome analyses. Clin Transl Med. 2025, 15(9):e70449.
4. Bai Z#, Li P#, Gao X#, Zu G, Jiang A, Wu K, Mechawar N, Turecki G, Lehnert K, Snell RG, Zhou J, Hu J, Yan B, Chen L, Li W, Chen Y*, Liu S*, Zhu Y*, You L*. Exploring PDE5A upregulation in bipolar disorder: insights from single-nucleus RNA sequencing of human basal ganglia. Transl Psychiatry 2024 Dec 18, 14(1):494.
5. Jiang A#*, You L#, Handley R, Hawkins V, Reid S, Jacobsen J, Patassini S, Rudiger S, Mclaughlan C, Kelly J, Verma P, Bawden C, Gusella J, MacDonald M, Waldvogel H, Faull R, Lehnert K, Snell RG. Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington’s Disease model. Hum Mol Genet 2024 18, 33(17):1524-1539.
6. Guo J#, You L#, Zhou Y, Hu J, Li J, Yang W, Tang X, Sun Y, Gu Y, Dong Y, Chen X, Sato C, Zinman L, Rogaeva E, Wang J, Chen Y*, Zhang M*. Spatial enrichment and genomic analyses reveal the link of NOMO1 with amyotrophic lateral sclerosis. Brain 2024, 147(8):2826-2841.
7. Zhao B#, Zhang H#, Liu Y#, Zu G, Zhang Y, Hu J, Liu S, You L*. Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory. Neural Regen Res 2024, 19(5):1133-1141.
8. Xian W#, Asad M#, Wu S#, Bai Z#, Li F, Lu J, Zu G, Brintnell E, Chen H, Mao Y, Zhou G, Liao B, Wu J*, Wang E*, You L*. Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma using single cell RNA-seq. Front Med 2024 Feb 18(1):147-168.
9. 俎高钰,李凤娇,咸伟伟,郭旸洋,赵百成,李文生,尤琳雅.人正常和帕金森病基底神经节的转录差异分析. 《解剖学报》 2024年8月, 55(4):439-449.
10.Chen Y#, Zu G#, Zhang B, Bai Z, Liu Q, Li W, You L*. Regional- and cell type-specific changes of human brain during aging (review). Human Brain 2023 2(3).
11.Xiong Z#, Wu S#, Li FJ, Luo C, Jin QY, Connolly ID, Hayden Gephart M*, You L*. Elevated ETV6 expression in glioma promotes an aggressive in vitro phenotype associated with shorter patient survival. Genes 2022 Oct 17, 13(10):1882.
12.Zu G#, Liu Y#, Cao J, Zhao B, Zhang H, You L*. BRPF1-KAT6A/KAT6B Complex: Molecular Structure, Biological Function and Human Disease (review). Cancers 2022 Aug 23, 14(17):4068.
13.Xian W#, Cao J#, Yuan X#, Wang G, Jin Q, Zhang H, Zhou G*, You L*. Deficiency of intellectual disability-related gene Brpf1 attenuated hippocampal excitatory synaptic transmission and impaired spatial learning and memory ability. Front Cell Dev Biol 2021 Aug 17, 9:711792.
14.Cao J, Xian W, Palihati M, Zhu Y, Wang G, Xie Y, Zhou G*, You L*. Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons. G3 2021 Aug 7, 11(8):jkab090.
15.李凤娇,咸伟伟,卜硕蕾,曹静丽,吴劲松,李文生*,尤琳雅*. 上海脑库脑组织样本的质量控制分析. 《解剖学报》2021年4月, 52(2): 168-174.
16.You L#, Li L#, Zou J, Yan K, Belle J, Nijnik A, Wang E, Yang XJ*. BRPF1 is essential for development of fetal hematopoietic stem cells. J Clin Invest 2016 Sep 1, 126(9):3247-62.
17.You L, Yan K, Zou J, Zhao H, Bertos NR, Park M, Wang E, Yang XJ*. The chromatin regulator Brpf1 regualtes embryo development and cell proliferation. J Biol Chem 2015 May 1, 290(18):11349-64.
18.You L, Zou J, Zhao H, Bertos NR, Park M, Wang E, Yang XJ*. Deficiency of the chromatin regulator BRPF1 causes abnormal brain development. J Biol Chem 2015 Mar 13, 290(11):7114-29.
19.You L, Yan K, Zou J, Zhao H, Bertos NR, Park M, Wang E, Yang XJ*. The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors. PLoS Genet 2015 Mar 10, 11(3):e1005034.
20.You L, Chen L, Penney J, Miao D, Yang XJ*. Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos. Epigenetics 2014 Jun, 9(6):860-72.
