Long Chen

Long Chen Intro

 

Long Chen M.D., Ph.D, Professor, Doctoral supervisor, Chief forensic medical examiner, hold a judicial practicing  certificate, Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University

 

Email: chenlong@shmu.edu.cn    

Tel: 021-54237566

Building Fayi, No.131 Dong’an Road, Xuhui District, Shanghai

 

1997-pres，Department of Forensic Medicine，Fudan University，Lecturer，Associate Professor，Professor

 2003,Jul-Aug/2004,Jul-Aug Forensic Center of Houston, TX, USA, Exchanging and Visiting

1994-1997, Department of Forensic Medicine, Tongji Medical University，M.D.，Ph.D.

1991-1994, Department of Forensic Medicine, Shanghai Medical University，M.S.

1988-1989, Department of Forensic Medicine, West China University of Medical Sciences，Medicolegal Seminar

1986,Mar-Jul, Department of pathology, Shanghai medical university，Neuropathology Seminar

1985-1991, Department of Forensic Medicine, Wannan Medical College，teaching assistant

1980-1985, Department of Clinical Medicine, Wannan Medical College，B.S.

 

2017-pres  Department of Forensic Medicine，Fudan University，Professor，Doctoral Supervisor

2008-pres  Ministry of Justice，Chief forensic medical examiner

2002-2008  Ministry of Justice，Associate chief forensic medical examiner

2001-2016  Department of Forensic Medicine，Fudan University，Associate Professor，Master Supervisor

1997-2000  Department of Forensic Medicine，Fudan University，the first Ph.D of Forensic Medicine in Shanghai，Lecturer

 

2015-pres  Member of the second Experts Group for Identification of Abnormal Reaction of Vaccination of Shanghai Medical Association

2012-pres  Council Member of the National Clinical Forensic Medicine Specialized Committee

2010-pres  Member of the professional committee of Shanghai judicial appraisal association.

2004-pres  Member of the Tripterygium Wilfordii Research Group of Dermatology and Venereal Professional Committee of Chinese Interactive Medicine Association

2002-pres  Member of the Experts Group for Medical Accident Technical Appraisal of Shanghai Medical Association

2002-pres  Member of Shanghai Road Traffic Accident Professional Committee

2002-pres  Member of the Expert Committee for Forensic Identification of Shanghai Bureau of Justice

2000-pres  Council Member of the National Forensic Pathology Specialized Committee

1998-pres  Council Member of Shanghai Forensic Association

As a forensic expert for the public security and the procuratorial department, many times invited to participate in major difficult cases appraisal

 

1. Editorial board member，Reviewer：Science & Justice（SCI journal of forensic medicine, the only editorial board member in Asia），Journal of Forensic Pathology，The Journal Forensic Sciences Methods and Techniques，Forensic studies，Journal of Forensic and Crime Investigation，Peertechz Journal of Forensic Science and Technology，Forensic Medicine and Anatomy Research，et al

2. Reviewer：Forensic Science International，Forensic Science Medicine and Pathology，Legal Medicine，Journal of Forensic and Legal Medicine，Journal of Forensic Sciences，Diagnostic Pathology，Plos One，Therapeutics and Clinical Risk Management，et al

 

Research Interests and Research Abstracts： 

1. Estimation of human postmortem interval (PMI) and its application in forensic identification

  The estimation of human postmortem interval (PMI) is one of the difficulties in the practice of forensic medicine at home and abroad. Accurate estimation of PMI is conducive to delineating the range of investigation quickly and locking suspects in time. Up to now, domestic and foreign PMI estimation lacks a way to “quantify”. It still mainly relies on the traditional ways, such as corpse phenomenon, which may lead to considerable errors. Based on the regular pattern of RNA degradation, the team successfully built a quantitative mathematical model of human PMI, which established a new method of PMI estimation and created a new research field of human PMI estimation. This project won the second prize of the 16th Shanghai medical science and technology award in 2017.

2. The identification and application of specific biomarker for mechanical asphyxia

  The accurate diagnosis of death due to mechanical asphyxia is always a difficult point in forensic identification. For lacking specific biomarkers for mechanical asphyxia, it is hard to diagnose the death as asphyxiation death, which brings troubles to criminal investigations and trials. Up to now, the team has discovered a series of significant indicators, such as mir-122, DUSP1 mRNA and KCNJ2 mRNA, which can be the potential specific biomarkers for mechanical asphyxia and may solve the problem in the accurate diagnosis of death due to mechanical asphyxia.

 

1.2017，Foundation of Forensic Pathology of Ministry of Public Security（GAFYBL201702），Estimating the human postmortem interval base on the regular pattern of mRNA degradation of human myocardial and brain tissue，0.1 million，Principal 

2.2016，National natural science foundation（81671863）， Identification and Biological Function Analysis of mRNA Markers for Early Postmortem Interval Estimation，0.56 million（Direct funds），Principal

3. 2013，National natural science foundation（81373242）， Identification of microRNA markers of asphyxia and reference markers of postmortem interval，0.7 million，Principal

4. 2011，National natural science foundation（81172896），The construction and application of mathematical model of human death time，0.52 million，Principal

5. 2007，Foundation and clinical cross-research fund of Fudan university；1998，American Chinese medical fund CMB fund；and so on，Principal

 

2017   The second prize of the sixteenth Shanghai Medical Science and Technology Award in 2017（rank the first）

2017   My graduate student（Zen Yan）won outstanding graduates from ordinary universities in Shanghai in 2017

2014   The third prize of the first PBL teaching plan competition of Shanghai Medical School of Fudan University

2009   The third prize of Shanghai Teaching Achievement Award

2009   My co-edited textbook Forensic Pathology won the second prize of national teaching achievements

2005  My co-edited textbook Forensic Pathology won the first prize of national excellent teaching material of medicine in colleges and universities

2004 Awarded the Outstanding Contribution Award by the Chinese Interactive Medicine Association for the research in Tripterygium wilfordii

2003  The third prize of the second Fudan university basic medicine education middle- youth award

 

Invited Presentations（Over the past five years, the national conference report and the special report of international important conference）

1. mRNA biomarkers of mechanical asphyxia-induced death in cardiac tissue，2017 the 19th International Conference on Forensic Science and Crime，London, UK(United Kingdom)

2.G6PC3,ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers, 2015 Symposium on Forensic Theory and Practice of Forensic Identification, Shanghai（The thesis has been awarded the outstanding paper of national judicial appraisal from 2015 to 2016）

3. Profiling of RNA degradation in deceased rat`s adipose tissue for determination of Postmortem Interval, 2013 the Forth International Conference on Evidence Law and Forensic Science, Beijing

4. Relationship between PMI and Relative Expression of Myocardial Various RNAs in Rats Died of Different Causes , 2013 the Ninth National Conference on Forensic Science and the Symposium of the Domestic and Foreign Court Science, Beijing

 

Representative Papers  More than 80 research papers, reviews and case studies have been published, including more than 20 SCI papers（mainly published in professional SCI journals of Forensic Medicine，such as International journal of legal medicine，Science & Justice，Forensic Science International，Forensic Science Medicine and Pathology，Journal of Forensic Sciences，Journal of Forensic and Legal Medicine，Romanian journal of legal medicine）. Representative Papers as follows. *corresponding author

1.Li Tao, Jianlong Ma(co-first author) , Liujun Han, Hongmei Xu, Yan Zeng, Lyu Yehuia, Wencan Li, Kaijun Ma, Bi Xiao*, Long Chen*.(2018).Early postmortem interval estimation based on Cdc25b mRNA in rat cardiac tissue. Legal Medicine. 35:18-24

2.Yan Zeng,Li Tao, Liujun Han, Jianlong Ma, Yehui Lv, Heng Zhang, Bi Xiao, Qun Shi, Kaijun Ma, Hongmei Xu and Long Chen*.(2018). DUSP1 and KCNJ2 mRNA up-regulation can serve as a biomarker of mechanical asphyxia-induced death in cardiac tissue. International Journal of Legal Medicine. 132(3), 655-665

3.Ye-Hui Lv, Jian-Long Ma,Hui Pan,Yan Zeng,Li Tao, Heng Zhang, Wen-Can Li, Kai-Jun Ma, Long Chen*.(2017). Estimation of the human postmortem interval using an established rat mathematical model and multi-RNA markers. Forensic Sci Med Pathol. 13(1), 20-27

4.Zeng Y, Lv Y, Tao L, Ma J, Zhang H, Xu H, Xiao B, Shi Q, Ma K, Chen L*. (2016). G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers. Oncotarget. 7(46), 74526-74536

5.Ye-Hui Lv,Jian-Long Ma, Hui Pan, Heng Zhang, Wen-Can Li, Ai-Min Xue, Hui-Jun Wang,Kai-Jun Ma, Long Chen*.(2016). RNA degradation as described by a mathematical model for postmortem interval determination. Journal of Forensic and Legal Medicine. 44, 43-52 

6.Jianlong Ma, Haojia Jing, Yan Zeng, Li Tao, Yulei Yang, Kaijun Ma, Long Chen*.(2016). Retrospective analysis of 319 hanging and strangulation cases between 2001 and 2014 in Shanghai. Journal of Forensic and Legal Medicine. 42, 19-24

7.Wei Sheng，Long Chen（co-first author），Huijun Wang，Xiaojing Ma，Duan Ma，Guoying Huang*. (2016). CpG island shore methylation of ZFPM2 is identified in tetralogy of Fallot samples. pediatric research. 80(1), 151-158

8.Jianlong Ma，Hui Pan，Yan Zeng，Yehui Lv，Heng Zhang，Aimin Xue，Jieqing Jiang，Kaijun Ma*，Long Chen*.(2015). Exploration of the R code-based mathematical model for PMI estimation using profiling of RNA degradation in rat brain tissue at different temperatures. Forensic Science Medicine and Pathology. 11（4）, 530-537 

9.Long Chen*,Hui Pan, Jianlong,Ma, Ye-Hui Lv,  Heng Zhang, Wencan Li. (2015). An overhung mute suspect died during restraint- Is this a case of positional asphyxia? Journal of Forensic and Legal Medicine. 33, 98-100

10.Ye-Hui Lv, Kai-Jun Ma, Heng Zhang, Meng He, Ping Zhang, Yi-wen Shen, Nan Jiang, Duan Ma and Long Chen*.(2014). A time course study demonstrating mRNA, microRNA, 18S rRNA and U6 snRNA changes to estimate PMI in deseased rat’s spleen. Journal of Forensic Sciences. 59(5), 1286-1294

11.Li Wen-Can, Ma Kai-Jun,Lv Ye-hui,Zhang-Ping, Pan-Hui,Zhang-Heng, Wang Hui-Jun, Ma Duan, Long Chen*.(2014). Postmortem interval determination using 18S-rRNA and microRNA. Science & Justice. 54(4), 307-310

12.Hui Pan, Yehui Lv, HengZhang, Aimin Xue, Long Chen*.(2014). Death from a special mechanical asphyxia during suspect restraint: a case report. Romanian journal of legal medicine.22(2), 81-84

13.Wei Sheng, Yanyan Qian, Ping Zhang, Yao Wu, Huijun Wang, Xiaojing Ma, Long Chen*, Duan Ma* and Guoying Huang*.(2014). Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot. Journal of Translational Medicine.12(31).DOI: 10.1186/1479-5876-12-31

14.Long Chen*，Guang-zhao Huang. (2013). Poisoning by toxic animals in China - 18 autopsy case studies and a comprehensive literature review. Forensic Science International. 232, e12–e23

15.Heng Zhang,Ping Zhang,Kai-jun Ma, Ye-Hui Lv,Wen-Can Li,Cheng-Liang Luo,Li-Liang Li,Yi-Wen Shen, Meng He, Jie-Qing Jiang, Long Chen*.(2013). The selection of endogenous genes in human postmortem tissues. Science & Justice 53(2), 115-20

16.Chen Long*, Huijun Wang*, Ziqin Zhao, Yihu Zhang and Guangzhao Huang.(2005). Effects of the extract of a Chinese herbal Tripterygium Wilfordii Hook. f. on rat pituitary gland. The American Journal of Chinese Medicine. 33(6), 945-955

 

1. Editor-in-chief of the textbook of《Forensic Medicine》(co-edited by nine universities) 

2. Deputy editor of the textbook of《Forensic Medicine》, Basic medicine undergraduate core  

  curriculum series of textbooks

3. Participated in the writing of other 16 books including《Forensic Pathology》(National teaching materials for colleges and  universities) , the textbook of《Forensic Medicine》(English version) , and《Practical Forensic Medicine》，et al.