HUI YANG, PH.D.
Associate Professor
Phone Number: 021-54237093
Fax: 021-54237093
Email: huiyang@fudan.edu.cn
Research Interests
Dr. Hui Yang’s research areas of focus: Cellular Immunology, Tumor Immunology and Immunotherapy. The research interests involve modulation of immune cell development and function, and mechanisms regulating immune cell homeostasis. The main focus is on identifying and understanding the controls that regulate immune cells, which will ultimately lead to better treatments for immune diseases and cancer.
Publications
1. Yu B, Pei C, Peng W, Zheng Y, Fu Y, Wang X, Wang W, Wang Z, Chen Y, Wang Q, Zhuma K, Gao Y, Xing Y, Jiao M, Liu R, Luo F, Zhang D, Qie J, Yang H, Jin M, Wang L, Chu Y. Microbiota-derived butyrate alleviates asthma via inhibiting Tfh13-mediated IgE production. Signal Transduct Target Ther. 2025 Jun 6;10(1):181.
2. Niu C, Wei H, Pan X, Wang Y, Song H, Li C, Qie J, Qian J, Mo S, Zheng W, Zhuma K, Lv Z, Gao Y, Zhang D, Yang H, Liu R, Wang L, Tu W, Liu J, Chu Y, Luo F. Foxp3 confers long-term efficacy of chimeric antigen receptor-T cells via metabolic reprogramming. Cell Metab. 2025 Jun 3;37(6):1426-1441.e7.
3. Li C, Niu C, Chen L, Yu B, Luo F, Qie J, Yang H, Qian J, Chu Y. Classical Monocytes Shuttling for Precise Delivery of Nanotherapeutics to Glioblastoma. Adv Healthc Mater. 2024 Nov;13(29):e2400925.
4. Dong L#, Cao Y#, Yang H#, Hou Y#, He Y, Wang Y, Yang Q, Bi Y*, Liu G*. The hippo kinase MST1 negatively regulates the differentiation of follicular helper T cells. Immunology. 2023 Mar; 168(3):511-525.
5. Zhao X, Yang W, Yu T, Yu Y, Cui X, Zhou Z, Yang H, Yu Y, Bilotta AJ, Yao S, Xu J, Zhou J, Yochum GS, Koltun WA, Portolese A, Zeng D, Xie J, Pinchuk IV, Zhang H, Cong Y. Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts. Gastroenterology. 2023 Jan;164(1):89-102.
6. Wang Y#, Yang H#, Jia A#, Wang Y#, Yang Q#, Dong Y, Hou Y, Cao Y, Dong L, Bi Y, Liu G*. Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer. Elife. 2022 Aug 22;11:e79957.
7. Li Y#, Jia A#, Yang H#, Wang Y#, Wang Y#, Yang Q, Cao Y, Bi Y, Liu G*. Protein Tyrosine Phosphatase PTPRO Signaling Couples Metabolic States to Control the Development of Granulocyte Progenitor Cells. J Immunol. 2022 Mar 15;208(6):1434-1444.
8. Lu Y#, Liu H#, Bi Y#, Yang H#, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G*. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15(6): 618–629
9. Li C#, Bi Y#, Li Y#, Yang H#, Yu Q, Wang J, Wang Y, Su H, Jia A, Hu Y, Han L, Zhang J, Li S, Tao W, Liu G*.Dendritic cell MST1 inhibits Th17 differentiation. Nat Commun. 2017 Feb 1;8:14275.
10. Chen X, Zhang Z, Bi Y, Fu Z, Gong P, Li Y, Yu Q, Jia A, Wang J, Xue L, Yang H* , Liu G*.mTOR signaling disruption from myeloid-derived suppressive cells protects against immune-mediated hepatic injury through the HIF1α-dependent glycolytic pathway. J Leukoc Biol. 2016 Dec;100(6):1349-1362.
11. Wang Y, Bi Y, Chen X, Li C, Li Y, Zhang Z, Wang J, Lu Y, Yu Q, Su H, Yang H, Liu G*. Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9 -Producing CD4(+) T Cells. Immunity. 2016 Jun 21;44(6):1337-49.
12. Zhao T#, Yang H#, Tian Y, Xie Q, Lu Y, Wang Y, Su N, Dong B, Liu X, Wang C, Jiang C*, Liu Q*. SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling. Cancer Lett. 2016 May 28;375(1):100-7.
13. Shao K, Lu Y, Wang J, Chen X, Zhang Z, Wang X, Wang X*, Yang H*, Liu G*. Different effects of tacrolimus on innate and adaptive immune cells in the allograft transplantation. Scand J Immunol. 2016 Feb;83(2):119-27.
14. Yang H, Bi Y, Xue L, Wang J, Lu Y, Zhang Z, Chen X, Chu Y, Yang R, Wang R, Liu G*. Multifaceted modulation of SIRT1 in cancer and inflammation. Crit Rev Oncog. 2015, 20 (1-2), 49-64.
15. Yang H, Bi Y, Han F, Lu Y, Wang J, Zhang Z, Liu G*. Myeloid-derived suppressor cells in immunity and autoimmunity. Expert Rev Clin Immunol. 2015, 11 (8) , 911-9.
16. Zhang Y#, Bi J#, Yang H# , Chen X#, Liu H, Lu Y, Zhang G, Liao J, Yang S, Chu Y, Yang R, Liu G*. mTOR limits the recruitment of CD11b+Gr1+Ly6Chigh myeloid-derived suppressive cells in protecting against murine immunological hepatic injury. J Leukoc Biol, 2014, 95 (6), 961-70.
17. Yang H, Wang X, Zhang Y, Liu H, Liao J, Shao K, Chu Y, Liu G*. Modulation of TSC1/2-mTOR signaling on immune cells in immunity and autoimmunity. J Cell Physiol. 2014, 229 (1), 17-26.
18. Bi Y#, Zhou J#, Yang H#, Wang X#, Zhang X, Wang Q, Wu X, Han Y, Song Y, Tan Y, Du Z, Yang H, Zhou D, Cui Y, Zhou L, Yan Y, Zhang P, Guo Z, Wang X, Liu G*, Yang R*. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-γ activated macrophage programming. J Immunol. 2014, 192 (2), 704-13.
19. Yu Y, Yang W, Yu T, Zhao X, Zhou Z, Yu Y, Xiong L, Yang H, Bilotta AJ, Yao S, Golovko G, Plasencia A, Quintana FJ, Zhou L, Li Y, Cong Y. Yu Y, Yang W, Yu T, Zhao X, Zhou Z, Yu Y, Xiong L, Yang H, Bilotta AJ, Yao S, Golovko G, Plasencia A, Quintana FJ, Zhou L, Li Y, Cong Y. Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis. iScience. 2022 Aug 24;25(9):105004.
20. Liu G*, Bi Y, Shen B, Yang H, Zhang Y, Wang X, Liu H, Lu Y, Liao J, Chen X, Chu Y. SIRT1 limits function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF1α-dependent glycolytic pathway. Cancer Res, 2014, 74 (3), 727-37.
21. Liu G*, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R. Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1. Proc Natl Acad Sci U S A. 2015, 112 (9), E957-65.