HUI YANG, PH.D.
Associate Professor
Phone Number: 021-54237093
Fax: 021-54237093
Email: huiyang@fudan.edu.cn
Research Interests
Dr. Hui Yang’s research areas of focus: Cellular Immunology, Tumor Immunology and Immunotherapy. The research interests involve modulation of immune cell development and function, and mechanisms regulating immune cell homeostasis. The main focus is on identifying and understanding the controls that regulate immune cells, which will ultimately lead to better treatments for immune diseases and cancer.
Publications
1. Yang H, Bi Y, Xue L, Wang J, Lu Y, Zhang Z, Chen X, Chu Y, Yang R, Wang R, Liu G*. Multifaceted modulation of SIRT1 in cancer and inflammation.Crit Rev Oncogenesis. 2014 in press, (invited review).
2. Yang H, Wang X, Zhang Y, Liu H, Liao J, Shao K, Chu Y, Liu G*. Modulation of TSC1/2-mTOR signaling on immune cells in immunity and autoimmunity. JCell Physiol, 2014, 229 (1), 17-26.
3. Bi Y, Zhou J, Yang H (Co-first author), Wang X, Zhang X, Wang Q, Wu X, Han Y, Song Y, Tan Y, Du Z, Yang H, Zhou D, Cui Y, Zhou L, Yan Y, Zhang P, Guo Z, Wang X, Liu G*, Yang R*. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-γ activated macrophage programming. JImmunol, 2014, 192(2), 704-13.
4. Zhang Y, Bi J, Yang H (Co-first author), Chen X, Liu H, Lu Y, Zhang G, Liao J, Yang S, Chu Y, Yang R, Liu G*. mTOR limits the recruitment of CD11b+Gr1+Ly6Chigh myeloid-derived suppressive cells in protecting against murine immunological hepatic injury. JLeukocyte Biol, 2014, 95(6), 961-70.
5. Liu G*, Bi Y, Shen B, Yang H, Zhang Y, Wang X, Liu H, Lu Y, Liao J, Chen X, Chu Y. SIRT1 limits function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF1α-dependent glycolytic pathway.Cancer Res, 2014, 74 (3), 727-37.
6. Liu G*, Bi Y, Wang R, Yang H, Zhang Y, Wang X, Liu H, Lu Y, Zhang Z, Chen W, Chu Y, Yang R. Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells.JImmunol, 2014, 192 (7), 3068-79.
7. Liu H, Yang H, Chen X, Lu Y, Zhang Z, Wang J, Zhang M, Xue L, Xue F, Liu G*. Cellular metabolism modulation in T lymphocyte immunity.Immunology, 2014, May 19: doi: 10.1111/imm.12321.
8. Liao J, Wang X, Bi Y, Shen B, Shao K, Yang H, Lu Y, Zhang Z, Chen X, Liu H, Wang J, Chu Y, Xue L, Wang X, Liu G*. Dexamethasone potentiates myeloid-derived suppressor cell function in prolonging allograft survival through nitric oxide. JLeukocyte Biol, 2014, 96 (5), 675-84.
9. Liu G*, Yang H, Chen X, Wang X, Chu Y. Modulation of neutrophil development and homeostasis. Curr Mol Med, 2013, 13 (8), 1270-83.
10. Liu G*, Yang H. Modulation of macrophage activation and programming in immunity. JCellPhysiol, 2013, 228 (3), 502-12.
11. Zhang Y, Wang X, Yang H, Liu H, Lu Y, Han L, Liu G*. Kinase AKT controls innate immune cell development and function. Immunology, 2013, 140 (2), 143-52.
12. Liu G*, Bi Y, Wang R, Shen B, Zhang Y, Yang H, Wang X, Liu H, Lu Y, Han F. Kinase AKT1 negatively controls neutrophil recruitment and function in mice. JImmunol, 2013, 191 (5), 2680-90.
13. Yang H, Liu C, Jamsen J, Wu Z, Wang Y, Chen J, Zheng L, Shen B*. The DNase domain containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Cell cycle, 2012, 11 (24), 4626-32.
14. Joo EJ, Yang H, Park Y, Park NY, Toida T, Linhardt RJ, KimYS*. Induction of Nucleolin Translocation by Acharan Sulfate in A549 Human Lung Adenocarcinomas. JCell Biochem, 2010, 110 (5), 1272-78.
15. Seong SY*, Yang H, Cho NH. Fusion Antigen Used in Preparing Mature Dendritic Cell-Vaccine for Immunotherapy. Korea, 2010,Patent No: KR1020090120104.
16. Yang H, Cho NH, Seong SY*. The TAT-conjugated N-terminal region of MUC1 induces protective immunity against MUC1-expressing tumors. Clin Exp Immunol, 2009,158 (2), 174-85.
17. He D, Yang H, Lin Q, Huang HL*. Arg9-peptide facilitates the internalization of an anti-CEA immunotoxin and potentiates its specific cytotoxicity to target cells. Int JBiochem Cell B, 2005, 37(1), 192-205
18. Yang H, Chao K, He D, Lin Q, You S, Huang HL*. Studies of the expression, purification, renaturation and biologic activity of an anti-CEA immunotoxin. Chinese J Biotechol, 2004, 20( 3), 348-51
19. He D, Yang H, Lin Q, Huang HL*. Biological Functions of Anti-CEA Immunotoxins. Prog Biochem Biophys. 2004, 31(4), 368-374
20. Chao K, He D, Yang H, Zhang Z, Lin Q, Guo GG, Huang HL*. Soluble expression of recombinant immunotoxin against human bladder carcinoma and its anti-tumor activity . Chinese J cell mol immunol, 2004, 20(5), 568-71
21. He D, Chao K, Yang H, Lin Q, Huang HL*. Single-chain antibodies selected from phage antibody library with similar binding activity but different expression level. High Technol Lett, 2003, 13(10), 30-35