Ph.D., Fudan University
Professor
Department of Immunology
School of Basic Medical Sciences, Fudan University
Mailbox 226, 138 Yi Xue Yuan Road
Shanghai 200032, China.
Tel: 86-21-5423-7093
Fax: 86-21-5423-7093
Email: weijuanzhang@fudan.edu.cn
Lab Staff and Students
Yangyang Qi, Yifan Chen, Wandi Li
Research Interests
Macrophage biology in development, homeostasis and disease.
Publications
1. Li R, Liu H, Cao Y, Wang J, Chen Y, Qi Y, Lv K, Liu X, Yu K, Lin C, Zhang H, He H, Li H, Chen L, Shen Z, Qin J, Zhang W*, Sun Y*, Xu J*. Identification and validation of favorable prognosis immunogenic subtype of gastric cancer with intratumoural CD103+CD8+ T cells abundance. Br J Cancer. 2020; DOI: 10.1038/s41416-020-0813-y. (Co-corresponding author, IF=5.416)
2. Hu B, Wang Z, Zeng H, Qi Y, Chen Y, Wang T, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Dai B, Guo J, Xu L*, Zhang W*, Xu J*. Blockade of DC-SIGN+ tumor-associated macrophages reactivates anti-tumor immunity and improves immunotherapy in muscle-invasive bladder cancer. Cancer Res. 2020; DOI: 10.1158/0008-5472.CAN-19-2254. (Co-corresponding author, IF=8.378)
3. Cao Y, He H, Li R, Liu X, Chen Y, Qi Y, Yu K, Wang J, Chen L, Zhang P, Lin C, Liu H, Zhang H, Li H, Shen Z, Huang H, Sun Y, Zhang W*, Qin J*, Xu J*. Latency-associated peptide identifies immunoevasive subtype gastric cancer with poor prognosis and inferior chemotherapeutic responsiveness. Ann Surg. 2020; DOI: 10.1097/SLA.0000000000003833. (Co-corresponding author, IF=9.476)
4. Liu X, Cao Y, Li R, Gu Y, Chen Y, Qi Y, Lv K, Wang J, Yu K, Lin C, Liu H, Zhang H, He H, Chen L, Zhang P, Shen Z, Qin J, Sun Y, Li H*, Huang H*, Zhang W*, Xu J*. Poor clinical outcomes of intratumoral dendritic cell–specific intercellular adhesion molecule 3–grabbing non-integrin–positive macrophages associated with immune evasion in gastric cancer. Eur J Cancer. 2020; 128:27-37. (Co-corresponding author, IF=6.680)
5. Zeng H, Liu Z, Wang Z, Zhou Q, Qi Y, Chen Y, Chen L, Zhang P, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Dai B, Guo J, Xu L*, Zhang W*, Xu J*. Intratumoral IL22-producing cells define immunoevasive subtype muscle-invasive bladder cancer with poor prognosis and superior nivolumab responses. Int J Cancer. 2020; 146(2):542-552.( Co-corresponding author, IF=4.982)
6. Lin C, He H, Liu H, Li R, Chen Y, Qi Y, Jiang Q, Chen L, Zhang P, Zhang H, Li H, Zhang W*, Sun Y*, Xu J*. Tumor-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer. Gut. 2019; 68(10):1764-1773. (Co-corresponding author, IF=17.943)
7. Fu Q, Xu L, Wang Y, Jiang Q, Liu Z, Zhang J, Zhou Q, Zeng H, Tong S, Qi Y, Hu B, Fu H, Xie H, Zhou L, Chang Y, Zhu Y, Dai B*, Zhang W*, Xu J*. Tumor-associated macrophage-derived IL-23 interlinks kidney cancer glutamine addiction with immune evasion. Eur Urol. 2019; 75(5): 752-763. (Co-corresponding author, IF=17.298)
8. WangJT, Li H, Zhang H, Chen YF, Cao YF, Li RC, Lin C, Wei YC, Xiang XN, Fang HJ, Zhang HY, Gu Y, Liu X, Zhou RJ, Liu H, He HY, Zhang WJ*, Shen ZB*, Qin J*, Xu JJ*. Intratumoral IL17-producing cells infiltration correlate with anti-tumor immune contexture and improved response to adjuvant chemotherapy in gastric cancer. Ann Oncol. 2019; 30(2): 266-273. (Co-corresponding author, IF=14.196)
9. Qi Y, Chang Y, Wang Z, Chen L, Kong Y, Zhang P, Liu Z, Zhou Q, Chen Y, Wang J, Bai Q, Xia Y, Liu L, Zhu Y, Xu L, Dai B, Guo J, Wang Y*, Xu J*, Zhang W*. Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response. Cancer Immunol Immunother. 2019; 68(12):2067-2080. (Co-corresponding author, IF=4.900)
10. Jiang Q, Fu Q, Chang Y, Liu Z, Zhang J, Xu L, Zhu Y, Wang Y, Zhang W*, Xu J*. CD19(+) tumor-infiltrating B-cells prime CD4(+) T-cell immunity and predict platinum-based chemotherapy efficacy in muscle-invasive bladder cancer. Cancer Immunol Immunother. 2019; 68(1): 45-56. (Co-corresponding author, IF=4.900)
11. Cao Y, Liu H, Li H, Lin C, Li R, Wu S, Zhang H, He H*, Zhang W*, Xu J*. Association of O6-Methylguanine-DNA Methyltransferase Protein Expression With Postoperative Prognosis and Adjuvant Chemotherapeutic Benefits Among Patients With Stage II or III Gastric Cancer. JAMA Surg. 2017; 152(11): e173120. (Co-corresponding author, IF=10.668)
12. Wang J, Lin C, Li H, Li R, Wu Y, Liu H, Zhang H, He H, Zhang W*, Xu J*. Tumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefits in patients with gastric cancer. Oncoimmunology. 2017; 6(11): e1353858. (Co-corresponding author, IF=5.333)
13. Yang L, Liu Y, An H, Chang Y, Zhang W*, Zhu Y, Xu L, Xu J*. High Expression of Colony-Stimulating Factor 1 Receptor Associates with Unfavorable Cancer-Specific Survival of Patients with Clear Cell Renal Cell Carcinoma. Ann Surg Oncol. 2016; 23(3): 1044-52. (Co-corresponding author, IF=3.681)
14. Zhang W, Liu H, Liu W, Liu Y, Xu J*. Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway. Cell Death Differ. 2015; 22(2): 287-97. (First author, IF=8.086)
15. Fu Q, Chang Y, An H, Fu H, Zhu Y, Xu L, Zhang W*, Xu J*. Prognostic Value of Interleukin-6 and Interleukin-6 Receptor in Organ-Confined Clear-Cell Renal Cell Carcinoma: A 5-Year Conditional Cancer-Specific Survival Analysis. Br J Cancer. 2015; 113(11): 1581-1589. (Co-corresponding author, IF=5.416)
16. Liu Z, Liu Y, Xu L, An H, Chang Y, Yang Y, Zhang W*, Xu J*. P2X7 receptor predicts postoperative cancer-specific survival of patients with clear-cell renal cell carcinoma. Cancer Sci. 2015; 106(9): 1224-1231. (Co-corresponding author, IF=4.751)
17. Zhang W, Zhou Q, Xu W, Cai Y, Yin Z, Gao X, Xiong S*. DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. J Biol Chem. 2013; 288(19): 13534-50. (First author, IF=4.106)
18. Zhang W, Cai Y, Xu W, Yin Z, Gao X, Xiong S*. AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation. J Clin Immunol. 2013; 33(5): 925-37. (Co-first author, IF=4.128)
19. Zhang W, Xu W, Xiong S*. Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol. 2011; 187(4): 1764-77. (First author, IF=4.718)
20. Chen M, Zhang W (co-first author), Xu W, Zhang F, Xiong S*. Blockade of TLR9 signaling in B cells impaired anti-dsDNA antibody production in mice induced by activated syngenic lymphocyte-derived DNA immunization. Mol Immunol. 2011; 48(12-13): 1532-9. (Co-first author, IF=3.064)
21. Zhang W, Cai Y, Xu W, Xiong S*. C-reactive protein functions as a negative regulator of macrophage activation induced by apoptotic DNA. Protein Cell. 2011; 2(8):672-9. (First author, IF=7.575)
22. Zhang W, Xu W, Xiong S*. Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J Immunol. 2010;184(11):6465-78. (First author, IF=4.718)