Bo Gao
P.h.D., Fudan University
Associate Professor
Address: 138 Yixueyuan Road,
Shanghai, 200032,
P. R. China
Mobil phone: 86-13601639018
Fax: 86-21-54237154
Lab Staff and Students
Rong Wu Lei Zhou Xiran He Juanxiu Hu Wangqin Shu
Research Interests
Dr. Gao’s research interest is in the area of innate antiviral immunity, especially those involved in hepatitis B virus (HBV) infection and persistence.
Chronic HBV infection is a major public health challenge worldwide. Although effective vaccine against HBV now exists, there are still more than 350 million chronic carriers, most of whom in Asia. Only in China, there are 130 million chronic carriers. The current anti-HBV strategies such as type I IFN and lamivudine are either fraught with adverse reactions or the rapid emergence of drug-resistant viral strains during the prolonged therapeutic treatment.
With the aim to develop new therapeutic strategy for chronic HBV infection, Dr. Gao’s research studies are focused on the innate anti-HBV signaling pathways, with a special interest on the possible involvement of autophagy, inflammasome activation or epigenetic modifications in these processes.
Publications
1) Lu M, Yu S, Xu W, Gao B (Co-corresponding author) and Xiong S. HMGB1 promotes systemic lupus erythematosus by enhancing macrophage inflammatory response. Journal of Immunology Research (Accept)
2) Wang Y, Gao B, Xiong S. Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis. Am J Physiol Heart Circ Physiol. 2014;307:H1438-47
3) Gao B, Xu W, Wang Y, Zhong L, Xiong S. Induction of TRIM22 by IFN-γ involves JAK and PC-PLC/PKC, but not MAPKs and pI3K/Akt/mTOR pathways. J Interf Cytok Res, 2013;33:578-87
4) Gao B, Wang Y, Xu W, Li S, Li Q, Xiong S. Inhibition of histone deacetylase activity suppresses IFN-γ induction of TRIM22 via CHIP-mediated proteasomal degradation of IRF-1. J Immunol, 2013;191(1):464-71
5) Gao B, Xu W, Zhong L, Zhang Q, Su Y, Xiong S. p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression independent of its histone acetyltransferase activity. Eur J Immunol, 2013;43:2174-84
6) Wang Y, Gao B (Co-first author), Xu W, Xiong S. BRG1 is indispensable for IFN-γ-induced TRIM22 expression, which is dependent on the recruitment of IRF-1. Biochem Biophys Res Commun. 2011; 410; 549–554
7) Yu S, Gao B (Co-first author), Xu W, DUAN Z, Xiong S. Identification of tripartite motif-containing 22 (TRIM22) as a novel NF-κB activator. Biochem Biophys Res Commun. 2011; 410; 247–251
8) Gao B, Wang Y, DUAN Z, Xu W, Xiong S. A 5' extended IFN-stimulating response element is crucial for IFN-gamma-induced tripartite motif 22 expression via interaction with IFN regulatory factor-1. J Immunol. 2010;185:2314-23
9) Gao B, DUAN Z, Xu W, Xiong S. Tripartite motif-containing 22 inhibits the activity of Hepatitis B Virus (HBV) core promoter, which is dependent on nuclear-located RING domain. Hepatology. 2009;50:424-33
10) Duan Z, Gao B (Co-first author), Xu W, Xiong S. Identification of TRIM22 as a RING finger E3 ubiquitin ligase. Biochem Biophys Res Commun. 2008; 374:502-506.
11) Gao B, Duan Z, Xu W, Xiong S. The effect of innate antiviral factor TRIM5α on Hepatitis B virus replication. Chinese Journal of Immunology, 2009;7:601-605. (Published in Chinese)
12) Gao B, Duan Z, Xu W, Xiong S. The contribution of N terminal RING domain and C terminal SPRY domain of TRIM22 to its transcription and translation. Journal of Microbes and Infection, 2010; 5:31-35. (Published in Chinese)
13) Gao B, Duan Z, Gao Z, Hong X, Xu W, Xiong S. The preparation and preliminary application of the epitope peptide-based antibody against TRIM22. Journal of Fudan University (Medical sciences). 2008; 35(5):697-701. (Published in Chinese)
14) Zhou Q, Gao B, Duan Z, Chen M, Xu W, Xiong S. Activation of primary macrophage by polyethylenimine-mediated intracytoplasmical delivery of apoptotic DNA. Current immunology. 2009; 29:95-99. (Published in Chinese)
15) Duan Z, Gao B, Hong X, Xu W, Zhou Q, Xiong S. Cloning and eukaryotic expression of the human tripartite motif protein 22 and its effect on the proliferation of Jurkat T cell. Current immunology. 2008; 28:285-290. (Published in Chinese)
16) Wu HQ, Liu ZG, Gao B, Li M, Ran PX, Xing M. Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana). Int J Immunogenet. 2007;3 4(5):347-51.
17) Wu HQ, Liu ZG, Ran PX, Zhou ZW, Gao B. Expression, purification, and immunological characterization of Cr PI. Protein Pept Lett. 2007; 14:881-5.
18) Gao B, Liu Z, Su D, Luo S. Refolding of the cockroach allergen Cr P1 from inclusion bodies. Acta Parasitologica et Medica Entomologica Sinica. 2004; 11:96-100. (Published in Chinese)
19) Liu Z, Bai Y, Ji K, Liu X, Cai C, Yu H, Li M, Bao Y, Lian Y, Gao B. Detection of Dermatophagoides farinae in the dust of air conditioning filters. Int Arch Allergy Immunol. 2007; 144:85-90