P.h.D., M.D.,Shanghai Medical College of Fudan Univ. Professor
Address: Rm. 805, Bldg.13
138 Yi XueYuan Rd
200032 SHANGHAI
Tel: (+86) 21-5423-7324
Fax: (+86) 21-5423-7324
Email: ywchu@shmu.edu.cn
Lab Staff and Students:
Postdoctoral fellow
Feifei Luo Luman Wang
Graduate students
Ronghua Liu Xiaoming Liu Jiawen Qian Yuting Deng Tingting Qian
Jiao Yang Xuechao Jiang Enyu Huang Zhou Lu
Administrative staff
Dan Zhang
Research Interests
The major scientific achievements of our research group include 1) We found both paclitaxel-based chemotherapy and radiotherapy change the immune pattern, which selectively reduce the number and impair the suppressive function of Treg, besides their direct inhibition of tumor cell proliferation. Also, TLR1/2 agonist, BLP, not only up-regulates the cytotoxicity T cells but also down-regulates regulatory T cells to enhance anti-tumor immune response, which will benefit tumor immunotherapies.2) Our studies found a set of microRNAs involve in the inflammation and tumor growth with the complex mechanisms, which provides specific target for the disease diagnosis and therapy. 3) We demonstrates for the first time that IL-10 producing B cells are down-regulated in cell number and immunosuppressive function in Grave’s disease, which might contribute to pathogenesis and relapse of disease.
The ongoing projects include 1) Combination of chemo-radiotherapy with immunotherapies in the treatment of cancer, specially in glioma in phase II clinical trail. 2) Immune regulators, such as non-coding RNA coordinate with innate immune cells in inflammation associated neoplastic transformation. 3)The immune regulating function of B cell in autoimmune disease.
Overall research goals: Based on the concept of translational medicine, we study the host immune functions in various disease, consequently provides the potential immunotherapy strategies.
Scientific objectives foucs on 1) making CAR-T for converting the immune suppresion to immune enhancement. 2) exploring the key microRNA and its target in the inflammation associated neoplastic transformation.3) working on regulatory B cell and its function.
Publications
1. Yuting Deng, Jiao Yang, Jiawen Qian, Ronghua Liu, Enyu Huang, Yuedi Wang,Feifei Luo⁎⁎, Yiwei Chu*(Corresponding author). TLR1/TLR2 signaling blocks the suppression of monocytic myeloid-derived suppressor cell by promoting its differentiation into M1-type macrophage. Molecular Immunology. 2019 Aug;112:266-273.
2. Hushan Zhang#, Luman Wang#, Yiwei Chu*(Corresponding author). Reactive oxygen species: The signal regulator of B cell. Free Radical Biology and Medicine. 2019 Oct;142:16-22.
3. Xinming Du, Jiawen Qian, Yujie Wang, Mingming Zhang⁎, Yiwei Chu*, Yingxia Li⁎.Identification and immunological evaluation of novel TLR2 agonists through
structure optimization of Pam3CSK4. Bioorganic & Medicinal Chemistry. 2019 Jul 1;27(13):2784-2800.
4. Tingting Qian#, Jiaxu Hong#, Luman Wang, Zhiming Wang, Zhou Lu, Yifan Li,
Ronghua Liu, Yiwei Chu*(Corresponding author). Regulation of CD11b by HIF-1α and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease. Molecular Immunology. 2019 Jul;111:162-171.
5. Qian J#, Wang C#, Wang B, Yang J, Wang Y, Luo F, Xu J, Zhao C, Liu R, Chu Y*.The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy. J Neuroinflammation. 2018 Oct 17;15(1):290.
6. Zhang H, Wang Z, Liu R, Qian T, Liu J, Wang L, Chu Y*. Reactive oxygen species stimulated pulmonary epithelial cells mediate the alveolar recruitment of FasL+ killer B cells in LPS-induced acute lung injuries. J Leukoc Biol. 2018 Dec;104(6):1187-1198.
7. Liu J, Li Y, Lu Z, Gu J, Liang Y, Huang E, Wang Z, Zhang H, Wang L, Zhang D, Yu H, Liu R, Chu Y*. Deceleration of glycometabolism impedes IgG-producing B cell-mediated tumor elimination by targeting SATB1. Immunology. 2019 Jan;156(1):56-68.
8. Yao Y#, Luo F#, Tang C#, Chen D#, Qin Z, Hua W, Xu M, Zhong P, Yu S, Chen D, Ding X, Zhang Y, Zheng X, Yang J, Qian J, Deng Y, Hoon DSB, Hu J, Chu Y*, Zhou L*. Molecular subgroups and B7-H4 expression levels predict responses to dendritic cell vaccines in glioblastoma: an exploratory randomized phase II clinical trial. Cancer Immunol Immunother. 2018 Nov;67(11):1777-1788.
9. Qian J, Luo F, Yang J, Liu J, Liu R, Wang L, Wang C, Deng Y, Lu Z, Wang Y, Lu M, Wang JY, Chu Y*.TLR2 Promotes Glioma Immune Evasion by Downregulating MHC Class II Molecules in Microglia. Cancer Immunol Res. 2018 Oct;6(10):1220-1233.
10. Wang Z, Zhang H, Liu R, Qian T, Liu J, Huang E, Lu Z, Zhao C, Wang L*,Chu Y*.Peyer's patches-derived CD11b+ B cells recruit regulatory T cells through CXCL9 in dextran sulphate sodium-induced colitis. Immunology. 2018 Nov;155(3):356-366.
11. Deng Y, Yang J, Luo F, Qian J, Liu R, Zhang D, Yu H, Chu Y*.mTOR-mediated glycolysis contributes to the enhanced suppressive function of murine tumor-infiltrating monocytic myeloid-derived suppressor cells. Cancer Immunology, Immunotherapy . 2018 Sep;67(9):1355-1364.
12. Zhiming W, Luman W, Tingting Q, Yiwei C*.Chemokines and receptors in intestinal B lymphocytes. J Leukoc Biol. 2018 May;103(5):807-819.
13. Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, Wang L, Yang J, Deng Y, Qian J, Luo F, Wang Z, Zhang H, Jiang X, Zhang D, Qian J, Liu G, Zhu H, Qian Y, Liu Z, Chu Y*. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2018 Feb;154(3):637-651
14. Lu Z, Liu J, Liu X, Huang E, Yang J, Qian J, Zhang D, Liu R, Chu Y*. MiR-15a/16-1 Suppresses AHR-dependent IL-22 Secretion in CD4+ T cells and Contributes to Immune-mediated Organ Injury. Hepatology. 2018 Mar;67(3):1027-1040
15. Wang Y, Luo F, Yang J, Zhao C, Chu Y*.New Chimeric Antigen Receptor Design for Solid Tumors. Front Immunol. 2017 Dec 22;8:1934.
16. Yang J, Liu R, Deng Y, Qian J, Lu Z, Wang Y, Zhang D, Luo F, Chu Y*.MiR-15a/16 deficiency enhances anti-tumor immunity of glioma-infiltrating CD8+ T cells through targeting mTOR. Int J Cancer. 2017 Nov 15;141(10):2082-2092.
17. Luo F, Qian J, Yang J, Deng Y, Zheng X, Liu J, Chu Y*. Bifunctional αHER2/CD3 RNA-engineered CART-like human T cells specifically eliminate HER2(+) gastric cancer. Cell Res. 2016 Jul;26(7):850-853.
18. Xuechao Jiang, Bingbing Zha, Xiaoming Liu, Ronghua Liu, Jun Liu, Enyu Huang, Tingting Qian, Jiajing Liu, Zhiming Wang, Dan Zhang, Luman Wang*, Yiwei Chu*.STAT6 Deficiency Ameliorates Graves' Disease Severity by Suppressing Thyroid Epithelial Cell Hyperplasia. Cell death and disease. (2016) 7, e2506.
19. Enyu Huang; Ronghua Liu; Zhou Lu; Jiajing Liu; Xiaoming Liu; Dan Zhang; Yiwei Chu*. NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis. Biochemical and Biophysical Research Communications(BBRC) 2016.474（2）252-258.
20. Zhou Lu, Ronghua Liu,Enyu Huang, Yiwei Chu*. MicroRNAs : New Regulators of IL-22. Cellular Immunology. （review）2016,304:1-8.
21. Liu X,Jiang X, Liu R, Wang L, Qian T, Zheng Y, Deng Y, Huang E, Xu F, Chu Y*.B cells expressing CD11b effectively inhibit CD4+ T cell responses and ameliorate experimental autoimmune hepatitis in mice. Hepatology. 2015 Nov;62(5):1563-75.
22. L Wang, A Ray, X Jiang, J-y Wang, S Basu, X Liu, T Qian, R He, BN Dittel and Y Chu *.T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-indu··ced colitis .Mucosal Immunology. 2015 Nov;8(6):1297-312.
23. Wei Lin, Zhichao Fan, Yuanzhen Suo, Yuting Deng, Min Zhang, Jiyang Wang, Xunbin Wei and Yiwei Chu*. The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response. Immunology and Cell Biology .2015;93(1):99-110 .
24. Ronghua Liu, Jie Gu, Pei Jiang, Yijie Zheng, Xiaoming Liu, Xuechao Jiang , Enyu Huang, Shudao Xiong,Fengkai Xu, Guangwei Liu, Di Ge, Yiwei Chu*. DNMT1-microRNA126 epigenetic circuit contributes to esophageal squamous cell carcinoma growth via ADAM9-EGFR-AKT signaling. Clin Cancer Res, 2015;21(4):854-63.
25. Wei Lin,Yuanzhen Suo,Yuting Deng,Zhichao Fan, Yijie Zheng,Xunbin Wei, Yiwei Chu* (corresponding). Morphological change of CD4+ T cell during contact with DC modulates T-cell activation by accumulation of F-actin in the immunology synapse. BMC Immunology 12/2015; 16(1). 49.
26. Yang J, Li W, Luo F, Zhao N, Zhang W, Zhang D, Qian J, Yu Y, Zheng X, Wang Y, Feng Y, Liu T, Chu Y*.Low Percentage of CD24hiCD27+CD19+ B Cells Decelerates Gastric Cancer Progression in XELOX-treated Patients. International Immunopharmacology 2015 Jun;26(2):322-7.
27. Enyu Huang, Ronghua Liu, Yiwei Chu*. MicroRNA-15a/16: as tumor suppressors and more. Future Oncology(Review) 11(16):2351-63 .
28. Yufei Zhang, Feifei Luo, Anning Li, Jiawen Qian, Zhenwei Yao, Xiaoyuan Feng, Yiwei Chu *. Systemic Injection of TLR1/2 Agonist Improves Adoptive Antigen-specific T Cell Therapy in Glioma-bearing Mice. Clinical Immunology. 2014;154(1):26-36.
29. Shudao Xiong, Yijie Zheng, Pei Jiang, Ronghua Liu, Xiaoming Liu, Jing Qian, Jie Gu, Lijun Chang, Di Ge, Yiwei Chu*. PA28gamma emerges as a novel functional target of tumor suppressor microRNA-7 in Non-Small Cell Lung Cancer. British Journal of Cancer. 2014, 110(2): 353-62.
30. Qing Lu, Ji-Yang Wang, Luman Wang, Xuechao Jiang, Yiwei Chu*. Self DNA from lymphocytes 1 that have undergone activation-induced cell death enhances murine B cell proliferation and antibody production. PLoS One. October 2014,Volume 9,Issue 10,e109095.
31. Zhang M, Luo F, Zhang Y, Wang L, Lin W, Yang M, Hu D, Wu X, Chu Y*. Pseudomonas aeruginosa Mannose-Sensitive Hemagglutinin Promotes T-Cell Response via Toll-Like Receptor 4-Mediated Dendritic Cells to Slow Tumor Progression in Mice. Journal of Pharmacology and Experimental Therapeutics. 2014, 349(2): 279-87.
32. Luman Wang, Xuechao Jiang, Xiaoming Liu, Yiwei Chu*. Local immune compartments are related to the severity of DSS induced Colitis. BioScience Trends. 2014; 8(5):242-7
33. Rong-hua LIU,Xiao-ming LIU, Yi-jie ZHENG, Pei JIANG ,Shu-dao XIONG, Naixiang Luo, Dongzhen Mu,Yi-Wei CHU* .MicroRNA-7 sensitizes human non-small cell lung cancer A549 cells to paclitaxel by targeting EGFR. Oncology Letter. 2014 Nov;8(5):2193-2200.
34. Yijie Zheng, Naixiang Luo, Dongzhen Mu, Pei Jiang, Ronghua Liu, Haozhe Sun, ; Shudao Xiong, Xiaoming Liu, Luman Wang, Yiwei Chu* .Lipopolysaccharide regulates biosynthesis of cystathionine <gamma>-lyase and hydrogen sulfide through toll-like receptor-4/p38 and toll-like receptor-4/NF-<kappa>B pathways in macrophages. In Vitro Cellular & Developmental Biology - Animal (9659) 2013, 49(9): 679-88.
35. Bing-Bing Zha, Lu-Man Wang, Xiao-Ming Liu, Jun Liu, Zao-Ping Chen, Jiong Xu, Li Sheng, Yi-Ming Li, Yi-Wei Chu*.Decrease in Proportion of CD19+CD24hiCD27+ B Cells and Impairment of Their Suppressive Function in Graves’ Disease. 2012 PloS One November 2012 | Volume 7 | Issue 11 | e49835.
36. Wang L, Zhao L, Lv J, Yin Q, Liang X, Chu Y, He R. BLT1-dependent Alveolar Recruitment of CD4+CD25+ Foxp3+ Regulatory T Cells Is Important for Resolution of Acute Lung Injury. Am J Respir Crit Care Med 2012,186 (10) 989-98.
37. Shu Yan, Luman Wang, Nan Liu, Ying Wang and Chu Yiwei* . Critical role of interleukin-17/interleukin-17 receptor axis in mediating Con A-induced hepatitis. Immunology and Cell Biology ,2012,90:421-428.
38. Pei Jiang, Ronghua Liu, Yijie Zheng, Xiaoming Liu, Lijun Chang, Shudao Xiong, Yiwei Chu*. MiR-34a Inhibits Lipopolysaccharide-induced Inflammatory Response through Targeting Notch1 in Murine Macrophages. Experimental Cell Research, 2012 (318),1175-1184.
39. Yijie Zheng, Shudao Xiong, Pei Jiang, Ronghua Liu, Xiaoming Liu, Jing Qian, Xiujuan Zheng, Yiwei Chu*. Glucocorticoids inhibit lipopolysaccharide–mediated I inflammatory response by downregulation of microRNA-155: A novel anti- inflammation mechanism. Free radical biology and medicine. 2012（52）, 1307-1317.
40. Shudao Xiong, Yijie Zheng, Pei Jiang, Ronghua Liu, Xiaoming Liu, Chu Yiwei *.MicroRNA-7 Inhibits the Growth of Human Non-Small Cell Lung Cancer A549 Cells through Targeting BCL-2. International Journal of Biological Sciences 2011,7（6）：805-814.
41. Yi Zhang, Feifei Luo, Yuchan Cai, Nan Liu, Luman Wang, Damo Xu and Chu Yiwei *. TLR1/TLR2 agonist induces tumor regression by reciprocal modulation of effector and regulatory T cells.Journal of Immunology. 2011, 186(4): 1963-9. Reviewed by: Faculty of 1000