| 基本信息 | 职 称:青年研究员 |
| 教育经历 | 2008-2014 中国科学技术大学 生物化学与分子生物学系 博士 2004-2008 湖南科技大学 生物技术系 本科 |
| 工作经历 | 2025-今 复旦大学 基础医学院 免疫学系 青年研究员 2022-2025 诺华生物医学研究所 首席科学家 2020-2022 斯克里普斯研究所 博士后 2017-2020 华盛顿大学医学院 博士后 2014-2016 诺华生物医学研究所 研究员 |
| 研究方向 | 病毒免疫逃逸机制及宿主免疫应答 蛋白质工程与反向疫苗学 免疫耐受缺陷与自身免疫疾病的分子机制 |
| 代表性论著 | 1. G. Song*, M. Yuan*, H. Liu*, T. Capozzola*, R. N. Lin, J. L. Torres, W. T. He, R. Musharrafieh, K. Dueker, P. Zhou, S. Callaghan, N. Mishra, P. Yong, F. Anzanello, G. Avillion, A. L. Vo, X. Li, Y. Zhang, M. Makhdoomi, Z. Feng, X. Zhu, L. Peng, D. Nemazee, Y. Safonova, B. Briney, A. B. Ward, D. R. Burton, I. A. Wilson, R. Andrabi, Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift. Cell Reports 44, 115948 (2025). Co-first author. 2. P. Zhou*, G. Song*, H. Liu*, M. Yuan, W.-t. He, N. Beutler, X. Zhu, L. V. Tse, D. R. Martinez, A. Schäfer, F. Anzanello, P. Yong, L. Peng, K. Dueker, R. Musharrafieh, S. Callaghan, T. Capozzola, O. Limbo, M. Parren, E. Garcia, S. A. Rawlings, D. M. Smith, D. Nemazee, J. G. Jardine, Y. Safonova, B. Briney, T. F. Rogers, I. A. Wilson, R. S. Baric, L. E. Gralinski, D. R. Burton, R. Andrabi, Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease. Immunity 56, 669-686 (2023). Co-first author. 3. L. M. Mindrebo*, H. Liu*, G. Ozorowski*, Q. Tran, J. Woehl, I. Khalek, J. M. Smith, S. Barman, F. Zhao, C. Keating, O. Limbo, M. Verma, J. Liu, R. L. Stanfield, X. Zhu, H. L. Turner, D. Sok, P.-S. Huang, D. R. Burton, A. B. Ward, I. A. Wilson, J. G. Jardine, Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins. Proceedings of the National Academy of Sciences of the United States of America 120, e2216612120 (2023). Co-first author. 4. H. Liu, I. A. Wilson, Protective neutralizing epitopes in SARS-CoV-2. Immunological Reviews 310, 76-92 (2022). Review article. Cover story. 5. H. Liu*, C. I. Kaku*, G. Song*, M. Yuan, R. Andrabi, D. R. Burton, L. M. Walker, I. A. Wilson, Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron. Communications Biology 5, 766 (2022). 6. H. Liu*, M. Yuan*, D. Huang, S. Bangaru, F. Zhao, C. D. Lee, L. Peng, S. Barman, X. Zhu, D. Nemazee, D. R. Burton, M. J. van Gils, R. W. Sanders, H. C. Kornau, S. M. Reincke, H. Pruss, J. Kreye, N. C. Wu, A. B. Ward, I. A. Wilson, A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection. Cell Host & Microbe 29, 806-818.e6 (2021). 7. H. Liu*, N. C. Wu*, M. Yuan*, S. Bangaru, J. L. Torres, T. G. Caniels, J. van Schooten, X. Zhu, C. D. Lee, P. J. M. Brouwer, M. J. van Gils, R. W. Sanders, A. B. Ward, I. A. Wilson, Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity. Immunity 53, 1272-1280.e5 (2020). Cover story. 8. M. Yuan*, H. Liu*, N. C. Wu*, C. D. Lee, X. Zhu, F. Zhao, D. Huang, W. Yu, Y. Hua, H. Tien, T. F. Rogers, E. Landais, D. Sok, J. G. Jardine, D. R. Burton, I. A. Wilson, Structural basis of a shared antibody response to SARS-CoV-2. Science 369, 1119-1123 (2020). Co-first author. 9. M. Zhang*, H. Liu*$, Y. Gao, Z. Zhu, Z. Chen, P. Zheng, L. Xue, J. Li, M. Teng, L. Niu, Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer. Structure 24, 1810-1820 (2016). Co-first author. Lead Contact corresponding author. |
| 代表性专利 | Corona virus spike protein binding compounds. WO2022106205A1 (2022) |
