杨慧 副教授

发表时间：2018-06-16阅读次数：4640次

担任

复旦大学基础医学院免疫学系 副教授
复旦大学基础医学院免疫学系 科研秘书

中国免疫学会移植免疫分会 委员

学习与科研

2018-2019  德克萨斯大学医学分部访问学者

2015-至今  复旦大学基础医学院免疫学系  副教授

2012-2015  复旦大学基础医学院免疫学系  讲师

2009-2012  浙江大学生命科学学院  博士后

2005-2009  韩国首尔国立大学医学院  博士

2002-2004  中国科学院遗传与发育生物学研究所  硕士论文

1998-2004  吉林大学生命科学学院/沈阳药科大学 联合培养  学士、硕士                 

研究重点

1. 免疫细胞的发育分化及功能调控
2. 肿瘤免疫治疗

申请的研究项目

2015-2017  国家自然科学基金青年基金 NSFC 81401740，负责人
2014-2016  教育部博士点新教师基金 20130071120040，负责人
2014-2015  国家基础科学人才培养基金项目 NSFC J1210041，负责人
2013-2015  复旦大学新进青年教师科研启动项目，负责人
2013-2014  上海市卫生局青年科研项目，负责人
2016-2019  国家自然科学基金面上项目NSFC 31570910，骨干
2014-2016  上海市卫计委重点项目20134261，骨干
2014-2016  上海市教委重点项目14ZZ009，骨干
2013-2016  上海市科委基础研究重点项目12JC14009001，骨干

担任的教学任务

《医学免疫学》 本科生必修课 授课

《Medical Immunology》 MBBS留学生必修课 授课

《细胞与分子免疫学》 研究生专业课 授课

《细胞与分子免疫学技术》 研究生专业课 授课

代表性论文

1. Dong L#, Cao Y#, Yang H#, Hou Y#, He Y, Wang Y, Yang Q, Bi Y*, Liu G*. The hippo kinase MST1 negatively regulates the differentiation of follicular helper T cells. Immunology. 2023 Mar;168(3):511-525.

2. Wang Y#, Yang H#, Jia A#, Wang Y#, Yang Q#, Dong Y, Hou Y, Cao Y, Dong L, Bi Y, Liu G*. Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer. Elife. 2022 Aug 22;11:e79957.

3. Zhao X, Yang W, Yu T, Yu Y, Cui X, Zhou Z, Yang H, Yu Y, Bilotta AJ, Yao S, Xu J, Zhou J, Yochum GS, Koltun WA, Portolese A, Zeng D, Xie J, Pinchuk IV, Zhang H, Cong Y.  Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts. Gastroenterology. 2023 Jan;164(1):89-102.

4. Yu Y, Yang W, Yu T, Zhao X, Zhou Z, Yu Y, Xiong L, Yang H, Bilotta AJ, Yao S, Golovko G, Plasencia A, Quintana FJ, Zhou L, Li Y, Cong Y. Yu Y, Yang W, Yu T, Zhao X, Zhou Z, Yu Y, Xiong L, Yang H, Bilotta AJ, Yao S, Golovko G, Plasencia A, Quintana FJ, Zhou L, Li Y, Cong Y. Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis. iScience. 2022 Aug 24;25(9):105004.

5. Li Y, Jia A, Yang H (co-first）, Wang Y, Wang Y, Yang Q, Cao Y, Bi Y, Liu G*. Protein Tyrosine Phosphatase PTPRO Signaling Couples Metabolic States to Control the Development of Granulocyte Progenitor Cells. J Immunol. 2022 Mar 15;208(6):1434-1444.

6. Li Y, Jia A, Wang Y, Dong L, Wang Y, He Y, Wang S, Cao Y, Yang H, Bi Y, Liu G. Immune effects of glycolysis or oxidative phosphorylation metabolic pathway in protecting against bacterial infection. J Cell Physiol. 2019 Nov;234(11):20298-20309. 

7. Lu Y, Liu H, Bi Y, Yang H (co-first）, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G*. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15(6): 618–629

8. Li C, Bi Y, Li Y, Yang H (co-first）, Yu Q, Wang J, Wang Y, Su H, Jia A, Hu Y, Han L, Zhang J, Li S, Tao W, Liu G*.Dendritic cell MST1 inhibits Th17 differentiation. Nat Commun. 2017 Feb 1;8:14275. 

9. Chen X, Zhang Z, Bi Y, Fu Z, Gong P, Li Y, Yu Q, Jia A, Wang J, Xue L, Yang H* (corresponding), Liu G*.mTOR signaling disruption from myeloid-derived suppressive cells protects against immune-mediated hepatic injury through the HIF1α-dependent glycolytic pathway. J Leukoc Biol. 2016 Dec;100(6):1349-1362. Epub 2016 Jul 26.

10. Wang Y, Bi Y, Chen X, Li C, Li Y, Zhang Z, Wang J, Lu Y, Yu Q, Su H, Yang H, Liu G*. Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells. Immunity. 2016 Jun 21;44(6):1337-49.

11. Zhao T, Yang H( co-first), Tian Y, Xie Q, Lu Y, Wang Y, Su N, Dong B, Liu X, Wang C, Jiang C, Liu Q*. SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling. Cancer Lett. 2016 May 28;375(1):100-7.

12. Shao K, Lu Y, Wang J, Chen X, Zhang Z, Wang X, Wang X, Yang H* (corresponding), Liu G*. Different effects of tacrolimus on innate and adaptive immune cells in the allograft transplantation. Scand J Immunol.2016 Feb;83(2):119-27.

13. Yang H, Liu C, Jamsen J, Wu Z, Wang Y, Chen J, Zheng L, Shen B*. The DNase domain containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Cell cycle, 11 (24) (2012), 4626-32.

14. Yang H, Wang X, Zhang Y, Liu H, Liao J, Shao K, Chu Y, Liu G*. Modulation of TSC1/2-mTOR signaling on immune cells in immunity and autoimmunity. J CellPhysiol, 229 (1) (2014), 17-26.

15. Bi Y, Zhou J, Yang H(co-first), Wang X, Zhang X, Wang Q, Wu X, Han Y, Song Y, Tan Y, Du Z, Yang H, Zhou D, Cui Y, Zhou L, Yan Y, Zhang P, Guo Z, Wang X, Liu G*, Yang R*. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-γ activated macrophage programming. J Immunol 192 (2) (2014), 704-13.

16. Yang H, Bi Y, Xue L, Wang J, Lu Y, Zhang Z, Chen X, Chu Y, Yang R, Wang R, Liu G*. Multifaceted modulation of SIRT1 in cancer and inflammation. Crit Rev Oncog. 20 (1-2) (2015), 49-64.

17. Zhang Y, Bi J, Yang H (co-first), Chen X, Liu H, Lu Y, Zhang G, Liao J, Yang S, Chu Y, Yang R, Liu G*. mTOR limits the recruitment of CD11b+Gr1+Ly6Chigh myeloid-derived suppressive cells in protecting against murine immunological hepatic injury. J Leukoc Biol, 95 (6) (2014), 961-70.

18. Yang H, Bi Y, Han F, Lu Y, Wang J, Zhang Z, Liu G*. Myeloid-derived suppressor cells in immunity and autoimmunity. Expert Rev Clin Immunol. 11 (8) (2015), 911-9.

19. Yang H, Cho NH, Seong SY*. The TAT-conjugated N-terminal region of MUC1 induces protective immunity against MUC1-expressing tumors. Clin Exp Immunol, 158 (2) (2009 Nov), 174-85.

20. Liu G*, Bi Y, Shen B, Yang H, Zhang Y, Wang X, Liu H, Lu Y, Liao J, Chen X, Chu Y. SIRT1 limits function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF1α-dependent glycolytic pathway. Cancer Res, 74 (3) (2014), 727-37.

21. Liu G*, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R. Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1. Proc Natl Acad Sci U S A. 112 (9) (2015), E957-65.

22. Liu G*, Bi Y, Wang R, Yang H, Zhang Y, Wang X, Liu H, Lu Y, Zhang Z, Chen W, Chu Y, Yang R. Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells.J Immunol, 192 (7) (2014), 3068-79.

23. Liu G*, Yang H, Chen X, Wang X, Chu Y. Modulation of neutrophil development and homeostasis. CurrMol Med, 13 (8) (2013), 1270-83.

24. Liu G*, Yang H. Modulation of macrophage activation and programming in immunity. J Cell Physiol, 228 (3) (2013), 502-12.

25. Joo EJ, Yang H, Park Y, Park NY, Toida T, Linhardt RJ, KimYS*. Induction of Nucleolin Translocation by Acharan Sulfate in A549 Human Lung Adenocarcinomas. J Cell Biochem, 110 (5) (2010), 1272-78.

26. Liu H, Yang H, Chen X, Lu Y, Zhang Z, Wang J, Zhang M, Xue L, Xue F, Liu G*. Cellular metabolism modulation in T lymphocyte immunity.Immunology, May 19: doi: 10.1111/imm.12321, 2014.

27. Zhang Y, Wang X, Yang H, Liu H, Lu Y, Han L, Liu G*. Kinase AKT controls innate immune cell development and function. Immunology, 140 (2) (2013), 143-52.

28. Liu G*, Bi Y, Wang R, Shen B, Zhang Y, Yang H, Wang X, Liu H, Lu Y, Han F. Kinase AKT1 negatively controls neutrophil recruitment and function in mice. J Immunol, 191 (5) (2013), 2680-90.

29. Liao J, Wang X, Bi Y, Shen B, Shao K, Yang H, Lu Y, Zhang Z, Chen X, Liu H, Wang J, Chu Y, Xue L, Wang X, Liu G*. Dexamethasone potentiates myeloid-derived suppressor cell function in prolonging allograft survival through nitric oxide. J Leukoc Biol, 96 (5) (2014), 675-84.

30. Chen X, Lu Y, Zhang Z, Wang J, Yang H, Liu G*. Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology. Immunology. 145 (4) (2015), 455-67.

31. Wang X, Bi Y, Xue L, Liao J, Chen X, Lu Y, Zhang Z, Wang J, Liu H, Yang H, Liu G*. The calcineurin-NFAT axis controls allograft immunity in myeloid-derived suppressor cells through reprogramming T cell differentiation. Mol Cell Biol. 35 (3) (2015), 598-609.

Patent

1. Seong SY, Yang H, Cho NH, et al. Fusion Antigen Used in Preparing Mature Dendritic Cell-Vaccine for Immunotherapy. Korea, KR1020090120104, 2010

联系方式

Tel: 021-54237093 Email:huiyang@fudan.edu.cn