张伟娟 教授

2019.12－至今    复旦大学基础医学院免疫学系 教授

2013.12－2019.11  复旦大学基础医学院免疫学系  副教授

2012.09－2013.11  复旦大学基础医学院免疫学系  讲师

2010.07－2012.08  复旦大学上海医学院    博士后

2007.09－2010.06  复旦大学上海医学院    博士

2002.09－2005.06  四川大学华西医学中心  硕士

        围绕巨噬细胞生物学方向，深入研究在自身免疫病和肿瘤发生过程中巨噬细胞异常重编程的分子机制及其功能意义，为开发靶向巨噬细胞异常重编程的免疫治疗策略奠定基础。以第一作者和通讯作者在Annals of Oncology（2019）、Gut（2019）、European Urology（2019）、Cancer Research（2020）、JAMA Surgery（2017）、Journal for Immunotherapy of Cancer（2020a、2020b）、Annals of Surgery（2022a、2022b）、Cell Death & Differentiation（2015）、Journal of Immunology（2011、2010）、Journal of Biological Chemistry（2013）、European Journal ofCancer（2020）、British Journal of Cancer（2020、2015）、International Journal of Cancer（2020）、Oncoimmunology（2021、2020a、2020b、2020c、2017）、Cancer Immunology Immunotherapy（2022、2021、2019a、2019b）等免疫学领域国际权威期刊发表SCI论文31篇，其中第一作者论文7篇，通讯作者论文24篇，影响因子10以上论文11篇，最高影响因子为32.976，ESI高被引论文1篇。担任Journal for Immunotherapy of Cancer，Frontiers in Oncology等杂志审稿人。

1. 《实用内科学》，人民卫生出版社，2017年10月第十五版， ISBN：9787117243957，参编第四篇“固有免疫与适应性免疫系统(第一章)和免疫损伤与疾病(第二章) ”。

申请的研究项目 

1.  国家自然科学基金面上项目（81871306），时间：2019-2022，项目负责人。

2.  国家自然科学基金面上项目（81671628），时间：2017-2020，项目负责人。

3.  国家自然科学基金面上项目（81471621），时间：2015-2018，项目负责人。

留学生医学免疫学《Cellular Molecular Immunology》全英语教学
本科生 《医学免疫学》、《免疫工程》
硕士生 《细胞与分子免疫学》

博士生《高级免疫学》

临床医学专业本科生导师，指导多名本科生开展科创项目

2017年复旦大学教学成果一等奖

2017年上海市教学成果二等奖

1. Fei Y, Cao Y, Gu Y, Fang H, Chen Y, Wang J, Liu X, Lv K, He X, Lin C, Liu H, Li H, He H, Li R*, Zhang H*, Zhang W*.Intratumoral Foxp3⁺RORγt⁺ T cell infiltration determines poor prognosis and immunoevasive contexture in gastric cancer patients. Cancer Immunol Immunother. 2022;71(1):1-11.(共同通讯作者，IF=6.968)

2. Zhang H, Li R, Cao Y, Gu Y, Lin C, Liu X, Lv K, He X, Fang H, Jin K, Fei Y, Chen Y, Wang J, Liu H, Li H, Zhang H*, He H*, Zhang W*. Poor clinical outcomes and immunoevasive contexture in intratumoral IL10-producing macrophages enriched gastric cancer patients. Ann Surg. 2022; 275:e626-e635. (共同通讯作者，IF=12.969)

3. Cao Y, He H, Li R, Liu X, Chen Y, Qi Y, Yu K, Wang J, Chen L, Zhang P, Lin C, Liu H, Zhang H, Li H, Shen Z, Huang H, Sun Y, Zhang W*, Qin J*, Xu J*. Latency-associated peptide identifies immunoevasive subtype gastric cancer with poor prognosis and inferior chemotherapeutic responsiveness. Ann Surg. 2022; 275: e163–e173. (共同通讯作者，IF=12.969)

4. Xia S, Gu Y, Zhang H, Fei Y, Cao Y, Fang H, Wang J, Lin C, Zhang H, Li H, He H, Xu J, Li R*, Liu H*, Zhang W*. Immune inactivation by APOBEC3B enrichment predicts response to chemotherapy and survival in gastric cancer. Oncoimmunology. 2021; 10(1):1975386. (共同通讯作者，IF=8.11)

5. Shi M, Gu Y, Jin K, Fang H, Chen Y, Cao Y, Liu X, Lv K, He X, Lin C, Liu H, Li H, He H, Qin J, Li R*, Zhang H*, Zhang W*.CD47 expression in gastric cancer clinical correlates and association with macrophage infiltration. Cancer Immunol Immunother. 2021; 70(7):1831-1840.  (共同通讯作者，IF=6.968)

6. Liu Z, Zhou Q, Wang Z, Zhang H, Zeng H, Huang Q, Chen Y, Jiang W, Lin Z, Qu Y, Xiong Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Xu L, Dai B, Guo J, Wang J*, Chang Y*, Zhang W*. Intratumoral TIGIT⁺ CD8⁺ T cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer. J Immunother Cancer. 2020; 8(2):e000978. (共同通讯作者，IF=13.751)

7. Zhou Q, Qi Y, Wang Z, Zeng H, Zhang H, Liu Z, Huang Q, Xiong Y, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Xu L, Dai B, Guo J, Zhu Y*, Zhang W*, Xu J*. CCR5 blockade inflames antitumor immunity in BAP1-mutant clear-cell renal cell carcinoma. J Immunother Cancer. 2020; 8(1):e000228. (共同通讯作者，IF=13.751)

8. Hu B, Wang Z, Zeng H, Qi Y, Chen Y, Wang T, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Dai B, Guo J, Xu L*, Zhang W*,Xu J*. Blockade of DC-SIGN⁺ tumor-associated macrophages reactivates antitumor immunity and improves immunotherapy in muscle-invasive bladder cancer. Cancer Res. 2020; 80(8):1707-1719. (共同通讯作者，IF=12.701 )

9. Liu X, Cao Y, Li R, Gu Y, Chen Y, Qi Y, Lv K, Wang J, Yu K, Lin C, Liu H, Zhang H, He H, Chen L, Zhang P, Shen Z, Qin J, Sun Y, Li H*, Huang H*, Zhang W*, Xu J*. Poor clinical outcomes of intratumoral dendritic cell–specific intercellular adhesion molecule 3–grabbing non-integrin–positive macrophages associated with immune evasion in gastric cancer. Eur J Cancer. 2020; 128:27-37. (共同通讯作者，IF=9.162 )

10. Li R, Liu H, Cao Y, Wang J, Chen Y, Qi Y, Lv K, Liu X, Yu K, Lin C, Zhang H, He H, Li H, Chen L, Shen Z, Qin J, Zhang W*, Sun Y*, Xu J*. Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103⁺ CD8⁺ T cells conferring favourable prognosis. Br J Cancer. 2020; 122(10):1525-1534. (共同通讯作者，IF=7.64)

11. Zeng H, Liu Z, Wang Z, Zhou Q, Qi Y, Chen Y, Chen L, Zhang P, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Dai B, Guo J, Xu L*, Zhang W*,Xu J*. Intratumoral IL22-producing cells define immunoevasive subtype muscle-invasive bladder cancer with poor prognosis and superior nivolumab responses. Int J Cancer. 2020; 146(2):542-552.(共同通讯作者，IF=7.396)

12. Fang H, Li R, Gu Y, Fei Y, Jin K, Chen Y, Cao Y, Liu X, Lv K, Wang J, Yu K, Lin C, Liu H, Li H, He H, Zhang W*, Zhang H*, Shen Z*.Intratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic response. Oncoimmunology. 2020; 9(1):1856468. (共同通讯作者，IF=8.11)

13. Gu Y, Chen Y, Jin K, Cao Y, Liu X, Lv K, He X, Lin C, Liu H, Li H, He H, Qin J, Li R*, Zhang H*, Zhang W*.Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients.Oncoimmunology. 2020; 9(1):1844402. (共同通讯作者，IF=8.11)

14. Huang Q, Zhou Q, Zhang H, Liu Z, Zeng H, Chen Y, Qu Y, Xiong Y, Wang J, Chang Y, Xia Y, Wang Y, Liu L, Zhu Y, Xu L, Dai B, Guo J, Wang Z*, Bai Q*, Zhang W*.Identification and validation of an excellent prognosis subtype of muscle-invasive bladder cancer patients with intratumoral CXCR5+ CD8+ T cell abundance.Oncoimmunology. 2020; 9(1):1810489. (共同通讯作者，IF=8.11)

15. Lin C, He H, Liu H, Li R, Chen Y, Qi Y, Jiang Q, Chen L, Zhang P, Zhang H, Li H, Zhang W*, Sun Y*, Xu J*. Tumor-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer. Gut. 2019; 68(10):1764-1773. (共同通讯作者，IF=23.059，ESI高被引论文)

16. Wang JT, Li H, Zhang H, Chen YF, Cao YF, Li RC, Lin C, Wei YC, Xiang XN, Fang HJ, Zhang HY, Gu Y, Liu X, Zhou RJ, Liu H, He HY, Zhang WJ*, Shen ZB*, Qin J*, Xu JJ*. Intratumoral IL17-producing cells infiltration correlate with anti-tumor immune contexture and improved response to adjuvant chemotherapy in gastric cancer. Ann Oncol. 2019; 30(2): 266-273. (共同通讯作者，IF=32.976)

17. Fu Q, Xu L, Wang Y, Jiang Q, Liu Z, Zhang J, Zhou Q, Zeng H, Tong S, Qi Y, Hu B, Fu H, Xie H, Zhou L, Chang Y, Zhu Y, Dai B*, Zhang W*,Xu J*. Tumor-associated macrophage-derived IL-23 interlinks kidney cancer glutamine addiction with immune evasion. Eur Urol. 2019; 75(5): 752-763.  (共同通讯作者，IF=20.096)

18. Qi Y, Chang Y, Wang Z, Chen L, Kong Y, Zhang P, Liu Z, Zhou Q, Chen Y, Wang J, Bai Q, Xia Y, Liu L, Zhu Y, Xu L, Dai B, Guo J, Wang Y*, Xu J*,Zhang W*. Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response. Cancer Immunol Immunother. 2019; 68(12):2067-2080. (共同通讯作者，IF=6.968)

19. Jiang Q, Fu Q, Chang Y, Liu Z, Zhang J, Xu L, Zhu Y, Wang Y, Zhang W*,Xu J*. CD19(+) tumor-infiltrating B-cells prime CD4(+) T-cell immunity and predict platinum-based chemotherapy efficacy in muscle-invasive bladder cancer. Cancer Immunol Immunother. 2019; 68(1): 45-56. (共同通讯作者，IF=6.968)

20. Cao Y, Liu H, Li H, Lin C, Li R, Wu S, Zhang H, He H*, Zhang W*, Xu J*. Association of O6-Methylguanine-DNA Methyltransferase Protein Expression With Postoperative Prognosis and Adjuvant Chemotherapeutic Benefits Among Patients With Stage II or III Gastric Cancer. JAMA Surg. 2017; 152(11): e173120. (共同通讯作者，IF=14.766)

21. Wang J, Lin C, Li H, Li R, Wu Y, Liu H, Zhang H, He H, Zhang W*, Xu J*. Tumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefits in patients with gastric cancer. Oncoimmunology. 2017; 6(11): e1353858. (共同通讯作者，IF=8.11)

22. Yang L, Liu Y, An H, Chang Y, Zhang W*, Zhu Y, Xu L, Xu J*. High Expression of Colony-Stimulating Factor 1 Receptor Associates with Unfavorable Cancer-Specific Survival of Patients with Clear Cell Renal Cell Carcinoma. Ann Surg Oncol. 2016; 23(3): 1044-1052. (共同通讯作者，IF=5.344)

23. Zhang W, Liu H, Liu W, Liu Y, Xu J*. Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway. Cell Death Differ. 2015; 22(2): 287-297. (第一作者，IF=15.828)

24. Fu Q, Chang Y, An H, Fu H, Zhu Y, Xu L, Zhang W*,Xu J*. Prognostic Value of Interleukin-6 and Interleukin-6 Receptor in Organ-Confined Clear-Cell Renal Cell Carcinoma: A 5-Year Conditional Cancer-Specific Survival Analysis. Br J Cancer. 2015; 113(11): 1581-1589. (共同通讯作者，IF=7.64)

25. Liu Z, Liu Y, Xu L, An H, Chang Y, Yang Y, Zhang W*, Xu J*. P2X7 receptor predicts postoperative cancer-specific survival of patients with clear-cell renal cell carcinoma. Cancer Sci. 2015; 106(9): 1224-1231. (共同通讯作者，IF=6.716)

26. Zhang W, Zhou Q, Xu W, Cai Y, Yin Z, Gao X, Xiong S*. DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. J Biol Chem. 2013; 288(19): 13534-13550. (第一作者，IF=5.157)

27. Zhang W, Cai Y (co-first author), Xu W, Yin Z, Gao X, Xiong S*. AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation. J Clin Immunol. 2013; 33(5): 925-937. (共同第一作者，IF=8.317)

28. Zhang W, Xu W, Xiong S*. Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol. 2011; 187(4): 1764-1777. (第一作者，IF=5.422)

29. Chen M, Zhang W (co-first author), Xu W, Zhang F, Xiong S*. Blockade of TLR9 signaling in B cells impaired anti-dsDNA antibody production in mice induced by activated syngenic lymphocyte-derived DNA immunization. Mol Immunol. 2011; 48(12-13): 1532-1539. (共同第一作者，IF=4.407)

30. Zhang W, Cai Y, Xu W, Xiong S*. C-reactive protein functions as a negative regulator of macrophage activation induced by apoptotic DNA. Protein Cell. 2011; 2(8):672-679. (第一作者，IF=14.87)

31. Zhang W, Xu W, Xiong S*. Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J Immunol. 2010;184(11):6465-6478. (第一作者，IF=5.422)