吕鸣芳 教授

吕鸣芳教授，复旦大学基础医学院免疫学系PI，博士生导师，系副主任，基础医学院副院长

1998-2003   博士，美国德克萨斯大学西南医学中心, 免疫学
1993-1996   硕士，复旦大学基础医学院药理学系, 药理学
1988-1993   学士，复旦大学上海医学院, 临床医学

2013- 至今   研究员/教授, PI, 复旦大学上海医学院免疫学系
2009- 2013   Staff Scientist, 美国国立卫生研究院(NIH), 过敏和传染病研究所(NIAID)
2006- 2009   Instructor, 美国德克萨斯大学西南医学中心,免疫和传染病学
2003-2006   博士后，美国德克萨斯大学西南医学中心,免疫和传染病学
1996   助教，复旦大学基础医学院药理学系,药理学

1. 巨噬细胞可塑性和抗感染免疫的调节机制
2. 肺肠黏膜免疫
3. 代谢性疾病的固有应答调控

主要从事固有免疫、抗感染免疫、黏膜免疫和代谢性疾病的研究，阐明宿主通过降解病原相关模式分子或危险相关分子模式分子而调控固有免疫应答、宿主防御和组织炎症及损伤的机制，以第一作者和/或通讯作者在Nat Immunol, J Exp Med, Cell Host Microbe, PloS Pathog, J Immunol，eLife等期刊上发表文章。

2004 青年科学家奖，第8届国际固有免疫和内毒素协会，日本京都 1/1

2009-2013， NIH performance award 1/1

2014 青年优秀论文奖，上海市免疫学会学术年会，中国上海 1/1

2017 复旦大学教学成果奖一等奖10/10

2018 复旦大学基础医学院，优秀奖 1/1

2022 复旦大学上海医学院医学名师培育工程重点项目1/2

2023 复旦大学本科教学成果奖一等奖 5/5

2024 复旦大学三八红旗手 1/1

2024 复旦大学教学成果奖特等奖  4/11

2025 上海市东方英才计划教师项目1/1

2025 复旦大学“廖凯原最受欢迎教师奖”1/1

2025 复旦大学上海医学院“正谊”育才奖 3/11

1.Gan, L., C.Y. Yu, J. Chen, B. Zou, Z. Xiao, W. Jiang, D. Li, Q. Sun, Z. Wang, C. Li, Y. Liu, Y. Chu, J. Tang, M. Fu, X. Li, R. Munford, and M. Lu*. 2025. Acyloxyacyl Hydrolase Prevents Colitis and Colitis-Associated Colorectal Cancer by Inactivating Stimulatory LPS in the Intestine. FASEB journal 39:e70566. (*通讯作者)

2.Wang, Z., N. Ojogun, Y. Liu, L. Gan, Z. Xiao, J. Feng, W. Jiang, Y. Chen, B. Zou, C. Yu, C. Li, A. Ashuo, X. Li, M. Fu, J. Wu, Y. Chu, R.S. Munford*, and M. Lu*. 2025. A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide. eLife 13: RP100731(*共同通讯作者)

3.Jiang, W.*, Y. Chen, C.Y. Yu, B. Zou, Y. Lu, Q. Yang, Z. Tang, W. Mao, J. Li, H. Han, L. Shao, J. Zeng, Y. Chu, J. Tang*, and M. Lu*. 2024. Alveolar epithelial cells shape lipopolysaccharide-induced inflammatory responses and reprogramming of alveolar macrophages. European journal of immunology e2350378. (*共同通讯作者)

4.Cheng, X., W. Jiang, Y. Chen, B. Zou, Z. Wang, L. Gan, Z. Xiao, C. Li, C.Y. Yu, Y. Lu, Z. Han, J. Zeng, J. Gu, T. Chu, M. Fu, Y. Chu, W. Zhang*, J. Tang*, and M. Lu*. 2023. Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance. PLoS pathogens 19:e1011556. (*共同通讯作者)  

5. Zou, B., M. Goodwin, D. Saleem, W. Jiang, J. Tang, Y. Chu, R.S. Munford, and M. Lu*. 2021. A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice. eLife 10: e70938. (*通讯作者)

6. Feng, J., W. Jiang, X. Cheng, B. Zou, A. Varley, T. Liu, G. Qian, W. Zeng, J. Tang, Q. Zhao, Y. Chu, Y. Wei, X. Li, R. Munford, and M. Lu*. 2021. A host lipase prevents lipopolysaccharide-induced foam cell formation. iScience 24, 103004. (*通讯作者)

7. Jiang, W., J. Le, P.Y. Wang, X. Cheng, M. Smelkinson, W. Dong, C. Yang, Y. Chu, P.M. Hwang, R.S. Munford, and M. Lu*. 2021. Extracellular Acidity Reprograms Macrophage Metabolism and Innate Responsiveness. Journal of immunology 206:3021-3031. (*通讯作者)

8. Munford, R.S.*, J.P. Weiss, and M. Lu*. 2020. Biochemical Transformation of Bacterial Lipopolysaccharide by acyloxyacyl hydrolase reduces host injury and promotes recovery. The Journal of biological chemistry 295:17842-17851. (综述，*共同通讯作者)

9. Qian, G., W. Jiang, B. Zou, J. Feng, X. Cheng, J. Gu, T. Chu, C. Niu, R. He, Y. Chu, and M. Lu*. 2018. LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma. The Journal of experimental medicine 215:2397-2412.  (*通讯作者)

10. Zou, B., W. Jiang, H. Han, J. Li, W. Mao, Z. Tang, Q. Yang, G. Qian, J. Qian, W. Zeng, J. Gu, T. Chu, N. Zhu, W. Zhang, D. Yan, R. He, Y. Chu, and M. Lu*. 2017. Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury. PLoS pathogens 13:e1006436.  (*通讯作者)

11.Lu, M.*, and R. Munford. 2016. LPS stimulates IgM production in vivo without help from non-B cells. Innate immunity 22:307-315.  (*通讯作者)

12. Lu, M., T. Kho, and R.S. Munford. 2014. Prolonged triglyceride storage in macrophages: pHo trumps pO2 and TLR4. Journal of immunology 193:1392-1397.

13. Lu, M.*, A.W. Varley, and R.S. Munford. 2013. Persistently active microbial molecules prolong innate immune tolerance in vivo. PLoS pathogens 9:e1003339.   (*通讯作者，Faculty 1000)

14. Lu, M.*, and R.S. Munford. 2011. The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo. Journal of immunology 187:3314-3320. (*通讯作者)

15. Lu, M.*, A.W. Varley, S. Ohta, J. Hardwick, and R.S. Munford. 2008. Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection. Cell host & microbe 4:293-302.  (*共同通讯作者，封面文章)

16. Lu, M., M. Zhang, A. Takashima, J. Weiss, M.A. Apicella, X.H. Li, D. Yuan, and R.S. Munford. 2005. Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria. Nature immunology 6:989-994.

17. Lu, M., M. Zhang, R.L. Kitchens, S. Fosmire, A. Takashima, and R.S. Munford. 2003. Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells. The Journal of experimental medicine 197:1745-1754.

Tel: 86-21-54237751

E-mail: mingfanglu@fudan.edu.cn

地址：东安路130号，复旦大学上海医学院