担任 | 复旦大学基础医学院免疫学系教授,博士生导师,系副主任,课题组长 |
学习与科研 | 1994-1999年:华西医科大学 临床医学 本科 |
研究重点 | 通过小鼠疾病模型和临床样品分析研究炎症相关疾病的免疫细胞分子机制。 |
教学专著 | 《间充质干细胞基础与临床》科学出版社,2012年4月第一版,参编章节 “间充质干细胞免疫调节的机制” |
申请的研究项目 | 在研项目 鉴定及研究一群表达FAP的脂肪组织巨噬细胞调控肥胖相关炎症的具体机制 √2019.5.1-2022.4.30上海市“优秀学科带头人”(19XD1400200)负责人 肿瘤相关成纤维细胞调控髓样细胞促肿瘤干性能力的机制研究 已结题项目 “联合条件敲除pDC的气道致敏诱发小鼠哮喘模型的建立以及pDC调节呼吸道病毒感染诱发哮喘的研究” √2018.1-2021.12 NSFC 面上项目 (81771679)负责人 √2012.1-2015.12国家自然科学基金 面上项目 (81172797) 负责人 “Chemerin 对免疫炎症的影响及作用机制的研究” |
承担的实践性教学 | 留学生免疫学“Cellular and Molecular Immunology”全英语教学 |
获得的奖励 | 2019年 上海市“优秀学科带头人”
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代表性论文 | * 为通讯作者 2. Lin Y, Xiao L, Cai Q, Zhu C, Li S, Li B, Liu T, Zhang Q, Wang Y, Li Y, He X, Pan D, Tang Q, Wu X, Pan W, Wang J, Li X*, He R*. The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit. Science Immunol. 2021 Jul 30;6(61):eabg9698. 3. Yin W, Li Y, Song Y, Zhang J, Wu C, Chen Y, Miao Y, Lin C, Lin Y, Yan D, Chen J, He R*. CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation. Proc Natl Acad Sci USA. 2021 Apr 20;118(16):e2024171118 4. Wu Y, Shi T, Wang J, He R*. Talabostat Alleviates Obesity and Associated Metabolic Dysfunction via Suppression of Macrophage-Driven Adipose Inflammation. Obesity (Silver Spring). 2021 Feb;29(2):327-336. 5. Deng B, Lin Y, Chen Y, Ma S, Cai Q, Wang W, Li B, Liu T, Zhou P, He R*, Ding F*. Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α. Cellular & Molecular Immunol 2021 Jan;18(1):219-229 6. He R*, Chen Y, Cai Q. The role of the LTB4-BLT1 axis in health and disease. Pharmacol Res. 2020 Aug;158:104857 7. Liang M, Lv J, Jiang Z, He H, Chen C, Xiong Y, Zhu X, Xue Y, Yu Y, Yang S, Wang L, Li W, Guan M, Wan W, He R*, Zou H*. The leukotriene B4-leukotriene B4 receptor 1 axis promotes myofibroblast differentiation and tissue fibrosis in systemic sclerosis. Arthritis & Rheumatology 2020 Jun;72(6):1013-1025 8. Lin Y, Li B, Yang X, Liu T, Shi, T, Deng B, Zhang Y, Jia L, Jiang Z, and He R*. Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis. Mucosal Immunol. 2019 Nov;12(6):1304-1315 9. Lin Y, Li B, Yang X, Cai Q, Liu W, Tian M, Luo H, Yin W, Song Y, Shi Y*, He R*. Fibroblastic FAP promotes intrahepatic cholangiocarcinoma growth via MDSCs recruitment. Neoplasia. 2019 Nov 20;21(12):1133-1142 10. Song Y, Yin W, Dan Y, Sheng J, Zeng Y, He R*. Chemerin partly mediates tumor-inhibitory effect of all-trans retinoic acid via CMKLR1-dependent NK cells recruitment. Immunology. 2019 Jul;157(3):248-256 11. Xiong Y, Cui X, Li W, Lv J, Du L, Mi W, Li H, Chen Z, Leng Q, Zhou H, He R*. BLT1 signaling in epithelial cells mediates allergic sensitization via promotion of IL-33 production. Allergy. 2018 Nov 3. 2019 Mar;74(3):495-506 12. Li W, Liu T, Xiong Y, Lv J, Cui X, He R*. Diesel exhaust particle promotes tumor lung metastasis via the induction of BLT1-mediated neutrophilic lung inflammation. Cytokine. 2018 Nov;111:530-540. 13. Lv J, Xiong Y, L Wen, Cui X, Cheng X, Leng Q, and He R*. IL-37 inhibits IL-4/IL-13-induced CCL11 production and lung eosinophilia in murine allergic asthma. Allergy 2018 Aug;73(8):1642-1652. 14. Yin W, Song Y, Liu Q, Wu Y, He R*. Topical treatment of All-trans Retinoic Acid inhibits murine melanoma partly by promoting CD8+ T cell immunity. Immunology. 2017 Oct;152(2):287-297 15. 13.Deng B, Lin Y, Ma S, Zheng Y, Yang X, Li B, Yu w, Xu Q, Liu T, Hao C, He R*, Ding F*. Leukotriene B4 - Leukotriene B4 receptor axis promotes cisplatin- induced acute kidney injury by modulating neutrophil recruitment. Kidney International 2017 Jul;92(1):89-100 16. Lin Y, Yang X, Liu W, Li B, Yin W, Shi Y*, and He R*. Chemerin plays a protective role in hepatocellular carcinoma by inhibiting the expression of GM-CSF and IL-6 and MDSC accumulation. Oncogene 2017 Jun 22;36(25):3599-3608 17. Lv J, Xiong Y, Wen L, Yang W, Zhao L, He R*.BLT1 mediates bleomycin-induced lung fibrosis independent of neutrophils and CD4+ T cells. J Immunol 2017 Feb 15;198(4):1673-1684 18. Yang X, Lin Y, Shi Y, Li B, Liu W, Yin W, Dang Y, Chu Y, Fan J*, and He R*. FAP promotes immunosuppression by cancer-associated fibroblasts in the tumor microenvironment via STAT3-CCL2 signaling. Cancer Research. 2016 Jul 15;76(14):4124-35.(高被引论文) 19. Xiao L, Yang X, Lin Y, Li S, Jiang J, Qian S, Tang Q, He R*, Li X*. Large adipocytes function as antigen presenting cells to activate CD4+ T cells via up-regulating MHCII in obesity. Int J Obes. 2016 Jan;40(1):112-20. 20. Lv J, Zou L, Zhao L, Yang W, Xiong Y, Li B, He R*. LTB4-BLT1 axis promotes OXA-induced contact dermatitis by directing skin homing of neutrophils and CD8+ T cells. Immunology 2015 Sep; 146 (1):50-8. 21. Liang M, Lv J, Zou L, Yang W, Xiong Y, Chen X, Guan M, He R*, Zou H*. A modified murine model of systemic sclerosis: bleomycin given by pump infusion induced skin and pulmonary inflammation and fibrosis. Lab Invest. 2015 Mar;95(3):342-50. 22. Zhao L, Yang W, Yang X, Lin Y, Lv J, Dou X, Luo Q, Dong J, Chen Z, Chu Y and He R*. Chemerin suppresses murine allergic asthma by inhibiting CCL2 production and subsequent airway recruitment of inflammatory dendritic cells. Allergy 2014 Jun;69(6):763-74 23. Lin Y, Yang X, Yue W, Xu X, Li B, Zou L and He R*. Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization. Cellular & Molecular Immunol 2014 Jul;11(4):355-66 24. Yin Q, Xu X, Lin Y, Lv J, Zhao L, and He R*. Ultraviolet B irradiation induces skin accumulation of plasmacytoid dendritic cells: A possible role for chemerin. Autoimmunity Epub ahead of print, December 12, 2013 25. Wang L, Zhao L, Yin Q, Lv J, Chu Y and He R*. BLT1-dependent alveolar recruitment of CD4+CD25+ Foxp3+ regulatory T cells is important for resolution of acute lung injury. Am J Respir CritCare Med 2012, Nov 15;186(10):989-98. 26. Oyoshi MK, He R (共同第一作者), Li Y, Mondal, S, Yoon J, Afshar R, Chen M ,Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF and Geha RS. LTB4 driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity 2012 Oct 19;37(4):747-58, 27. He R, Oyoshi MK, Wang JY, Hodge MR, Jin H, and Geha RS. The prostaglandin D(2) receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J Allergy Clin Immunol. 2010; 126(4):784-90 28. He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S , Bryce P, Freyschmidt EJ, McKenzie AJ, Umetsu DT, Oettgen HC and Geha RS. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol 2009; 124(4):761-770.e1 29. He R and Geha RS. Thymic Stromal Lymphopoietin. Ann N Y Acad Sci.2010;1183:13-24 30. He R, Oyoshi MK, Garibyan L, Kumar L, Ziegler SF and Geha RS. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A 2008; 105(33):11875-80 31. He R, Oyoshi MK, Jin H, Geha RS. Epicutaneous antigen exposure induces a TH17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci USA 2007; 104(40): 15817-22 |
联系方式 | Tel:86-21-54237419 E-mail: ruihe@fudan.edu.cn |