李蓓

发表时间：2022-02-25 阅读次数：5790次

博士、青年副研究员

研究方向：

神经退行性疾病的发病机制和治疗方法

研究工作聚焦于神经退行性疾病脑内蛋白聚集体的毒性和清除机制。先后主持中国博士后科学基金面上项目一等资助，国家自然科学基金委员会的青年基金项目，复旦大学人才引进资助项目，并参与国家自然科学基金面上项目和上海市人才项目。研究结果以第一或通讯作者发表于J Exp Med，Acta Neuropathol Commun.和Commun Biol.等期刊。

学习和工作简历

2022.02 - 至今复旦大学，基础医学院中西医结合学系，青年副研究员

2019.10 – 2022.01 复旦大学，基础医学院神经生物学系，博士后

2011.04 – 2017.02 瑞士苏黎世大学，分子生物学系，博士

2010.01 – 2011.03 瑞士苏黎世大学医院，神经病理学研究所，研究助理

2005.09 – 2008.03 同济大学，生物化学与分子生物学系，硕士

2001.09 – 2005.06 扬州大学，生物技术系，本科

论文论著

1. Bei Li^#, Yiyue Shi^#, Wenyu Hou^#, Haoyuan Guan, Jun Li, Tuo Yi, Wei Li, Donglin Cai, Petra Schwarz, Adriano Aguzzi, Caihong Zhu. Ablation of progranulin augments microglial activation and accelerates prion progression. Acta Neuropathologica Communications. 2025;13(1):214.

2. Yiyue Shi, Wenyu Hou, Bei Li﹡, Caihong Zhu﹡. PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseases. Communications Biology. 2025;8(1):844.

3. Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu. The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine (Berlin, Germany). 2021; 99(6), 877–887.

4. Bei Li^#, Meiling Chen^#, Caihong Zhu.Neuroinflammation in Prion Disease. International Journal of Molecular Sciences.2021;22(4), 2196.

5. Caihong Zhu^#, Bei Li^#, Karl Frontzek, Yingjun Liu, Adriano Aguzzi. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. The Journal of Experimental Medicine. 2019; 216(4), 743–756.

6. Marian Hruska-Plochan^#, Bei Li^#, Diego Kyburz, Jan Krützfeld, Ulf Landmesser, Adriano Aguzzi, Magdalini Polymenidou. New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases. Swiss Medical Weekly. 2015;145, w14192.

7. Caihong Zhu, Zhihao Li, Bei Li, Manuela Pfammatter, Simone Hornemann, Adriano Aguzzi. Unaltered prion disease in mice lacking developmental endothelial locus-1. Neurobiology of Aging. 2019; 76, 208–213.

8. Uli S Herrmann, Anne K Schütz, Hamid Shirani, Danzhi Huang, Dino Saban, Mario Nuvolone, Bei Li, Boris Ballmer, Andreas K O Åslund, Jeffrey J Mason, Elisabeth Rushing, Herbert Budka, Sofie Nyström, Per Hammarström, Anja Böckmann, Amedeo Caflisch, Beat H Meier, K Peter R Nilsson, Simone Hornemann, Adriano Aguzzi. Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine. 2015; 7(299), 299ra123.

9. Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of Aging. 2015; 36(5), 1994–2003.

10. Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathogens. 2015; 11(2), e1004662.

11. Tiziana Sonati, Regina R Reimann, Jeppe Falsig, Pravas Kumar Baral, Tracy O'Connor, Simone Hornemann, Sine Yaganoglu, Bei Li, Uli S Herrmann, Barbara Wieland, Mridula Swayampakula, Muhammad Hafizur Rahman, Dipankar Das, Nat Kav, Roland Riek, Pawel P Liberski, Michael N G James, Adriano Aguzzi. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013; 501(7465), 102–106.

12. Jeppe Falsig, Tiziana Sonati, Uli S Herrmann, Dino Saban, Bei Li, Karina Arroyo, Boris Ballmer, Pawel P Liberski, Adriano Aguzzi. Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. PLoS Pathogens. 2012; 8(11), e1002985.

联系方式

Email: beili@fudan.edu.cn

地址:上海市东安路130号，复旦大学基础医学院中西医结合学系

邮编:200032