李蓓

发表时间：2022-02-25 阅读次数：5140次

博士、青年副研究员

研究方向：

1.神经退行性疾病的发病机制和诊治方法

2.全自动高通量筛选在疾病研究和药物开发中的应用

长期从事Prion病及其相关的神经退行性疾病的发病机制和诊治研究。博士毕业于瑞士苏黎世大学分子生物学系神经病理学研究所，参与瑞士国家科学基金和欧洲研究委员会高级研究基金等项目。在复旦大学基础医学院完成博士后工作，获中国博士后科学基金面上资助一等。研究了小胶质细胞在Prion病中的作用和分子机制，研究发现:免疫应答调节分子SARM1在Prion病的发病过程中通过抑制促凋亡因子XAF1的表达起神经保护作用的分子机制;巨噬细胞清道夫受体分子Msr1对脑内Prion的清除机制有别于Aβ。研究结果发表于J Exp Med，J Mol Med，Int J Mol Sci 等期刊。现主持国家自然科学基金青年基金项目1项，复旦大学引进人才资助1项，参与国家自然科学基金和上海市人才项目等。

学习和工作简历

2022.02 - 至今复旦大学，基础医学院中西医结合学系，青年副研究员

2019.10 – 2022.01 复旦大学，基础医学院神经生物学系，博士后

2011.04 – 2017.02 瑞士苏黎世大学，分子生物学系，博士

2010.01 – 2011.03 瑞士苏黎世大学医院，神经病理学研究所，研究助理

2005.09 – 2008.03 同济大学，生物化学与分子生物学系，硕士

2001.09 – 2005.06 扬州大学，生物技术系，本科

论文论著

1. Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu. The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine (Berlin, Germany). 2021; 99(6), 877–887.

2. Bei Li#, Meiling Chen#, Caihong Zhu.Neuroinflammation in Prion Disease. International Journal of Molecular Sciences. 2021;22(4), 2196.

3. Caihong Zhu#, Bei Li#, Karl Frontzek, Yingjun Liu, Adriano Aguzzi. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. The Journal of Experimental Medicine. 2019; 216(4), 743–756.

4. Marian Hruska-Plochan#, Bei Li#, Diego Kyburz, Jan Krützfeld, Ulf Landmesser, Adriano Aguzzi, Magdalini Polymenidou. New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases.Swiss Medical Weekly. 2015;145, w14192.

5. Caihong Zhu, Zhihao Li, Bei Li, Manuela Pfammatter, Simone Hornemann, Adriano Aguzzi. Unaltered prion disease in mice lacking developmental endothelial locus-1. Neurobiology of Aging. 2019; 76, 208–213.

6. Uli S Herrmann, Anne K Schütz, Hamid Shirani, Danzhi Huang, Dino Saban, Mario Nuvolone, Bei Li, Boris Ballmer, Andreas K O Åslund, Jeffrey J Mason, Elisabeth Rushing, Herbert Budka, Sofie Nyström, Per Hammarström, Anja Böckmann, Amedeo Caflisch, Beat H Meier, K Peter R Nilsson, Simone Hornemann, Adriano Aguzzi. Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine. 2015; 7(299), 299ra123.

7. Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of Aging. 2015; 36(5), 1994–2003.

8. Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathogens. 2015; 11(2), e1004662.

9. Tiziana Sonati, Regina R Reimann, Jeppe Falsig, Pravas Kumar Baral, Tracy O'Connor, Simone Hornemann, Sine Yaganoglu, Bei Li, Uli S Herrmann, Barbara Wieland, Mridula Swayampakula, Muhammad Hafizur Rahman, Dipankar Das, Nat Kav, Roland Riek, Pawel P Liberski, Michael N G James, Adriano Aguzzi. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013; 501(7465), 102–106.

10. Jeppe Falsig, Tiziana Sonati, Uli S Herrmann, Dino Saban, Bei Li, Karina Arroyo, Boris Ballmer, Pawel P Liberski, Adriano Aguzzi. Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. PLoS Pathogens. 2012; 8(11), e1002985.

联系方式

Email: beili@fudan.edu.cn

地址:上海市东安路130号，复旦大学基础医学院中西医结合学系

邮编:200032