中文 ENGLISH

毛应启梁

发表时间:2022-02-25 阅读次数:3610

博士、副教授、硕士生导师
研究方向:

    1.针刺缓解神经痛、炎症痛、癌痛的神经生物学机制研究

    2.针刺缓解化疗引起感觉异常的作用机制研究

建立了Walker 256大鼠乳腺癌致胫骨癌痛模型并通过比较骨癌痛与神经痛、炎症痛,观察了Toll样受体介导的脊髓神经炎症在骨癌痛中的作用以及Toll样受体在针刺缓解慢性痛中的作用。目前主要从脊髓小胶质细胞活化调控的角度研究针刺缓解不同慢性痛的作用机制,以及针刺缓解化疗引起的外周感觉异常(疼痛与感觉迟钝)行为的作用机制。先后承担国家自然科学基金青年项目1项和面上项目2项、上海市卫生局科研课题1项。已在BBI、Molecular Brain等杂志发表第一作者或通讯作者学术论文十余篇。

学习和工作经历

    2014.12 - ,任复旦大学基础医学院中西医结合学系副教授

    2012.8 - 2013.11, MD Anderson Cancer Center症状研究系博士后

    2011.11 - 2012.8, University of Illinois at Urbana-Champaign动物科学系博士后

    2007.7留校,先后任复旦大学基础医学院中西医结合学系助教、讲师(2007.10 - 2014.12)

    2002.9 - 2007.7, 复旦大学上海医学院中西医结合基础专业博士研究生

    1997.9 - 2002.7,复旦大学上海医学院(原上海医科大学)基础医学专业本科

发表论文

  1. Yu Chen #, Yang Zhou #, Xiao-Chen Li, Xue Ma, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice. Biol Res. 2022, 55(1):5.

  2. Xue Ma, Yu Chen, Xiao-Chen Li, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Spinal Neuronal GRK2 Contributes to Preventive Effect by Electroacupuncture on Cisplatin-Induced Peripheral Neuropathy in Mice. Anesth Analg. 2022, 134(1): 204-215. 

  3. Hu LY, Mi WL, Wu GC, Wang YQ, Mao-Ying QL*. Prevention and Treatment for Chemotherapy-Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms. Curr Neuropharmacol. 2019,17(2):184-196. (Review)

  4. Hu LY, Yang-Zhou, Cui WQ, Hu XM, Du LX, Mi WL, Chu YX, Wu GC, Wang YQ, Mao-Ying QL*. Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice. Brain Behav Immun. 2018, 68: 132-145.

  5. Liu H, Liu SB, Li Q, Wang H, Wang YQ, Mao-Ying QL*. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evid Based Complement Alternat Med. 2015:848603.

  6. Mao-Ying QL, Kavelaars A, Krukowski K, Huo XJ, Zhou W, Price TJ, Cleeland C, Heijnen CJ. The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model. PLoS One. 2014, 23;9(6):e100701

  7. Li X, Wang XW, Feng XM, Zhou WJ, Wang YQ, Mao-Ying QL*, Stage-dependent anti-allodynic effects of intrathecal Toll-like receptor 4 antagonists in a rat model of cancer induced bone pain. J Physiol Sci. 2013, 63(3):203-9.

  8. Mao-Ying QL, Wang XW, Yang CJ, Li X, Mi WL, Wu GC, Wang YQ. Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats. Mol Brain. 2012, 5:16.

  9. Yang CJ, Li Q, Wu GC, Wang YQ, Mao-Ying QL*. A practical model of osteomyelitis-induced bone pain by intra-tibial injection of Staphylococcus aureus in rats. Neurosci Lett. 2012, 513(2):198-203.

  10. Yang CJ, Wang XW, Li X, Wu GC, Wang YQ, Mao-Ying QL*. A rat model of bone inflammation-induced pain by intra-tibial complete Freund's adjuvant injection. Neurosci.Lett. 2011, 490(3):175-9.

  11. Qi-Liang Mao-Ying, Jun Zhao, Zhi-Qiang Dong, Jun Wang, Jin Yu, Min-Fen Yan, Yu-Qiu Zhang, Gen-Cheng Wu, Yan-Qing Wang. A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells. Biochemical and Biophysical Research Communication. 2006, 345: 1292-1298.

  12. Qi-Liang Mao-Ying, Ke-Mi Cui, Qiong Liu, Zhi-Qiang Dong, Wei Wang, Jun Wang, Hong Sha, Gen-Cheng Wu, Yan-Qing Wang. Stage-dependent analgesia of electro-acupuncture in a mouse model of cutaneous cancer pain. European Journal of Pain. 2006, 10(8): 689-94.

  13. Shan Sun, Qi-Liang Mao-Ying, Hong Cao, Tingting Li, Mei Han, Haili Pan, Yan-Qing Wang, Zhi-Qi Zhao and Yu-Qiu Zhang. Is functional state of spinal microglia involved in the anit-allodynic and anti-hyperalgesic effects of electroacupuncture in rat model of monoarthritis? Neurobiology of Disease. 2007, 26(3): 558-68.

  14. Qi-Liang Mao-Ying, Dian-Huan Ren, Wen-Li Mi, Qiong Liu, Yan-Qing Wang. Analgesic effects of electroacupuncture combined with Celebrex on rats with tibial cancer pain. Journal of Chinese Integrative Medicine. 2008, 6(8): 830-835. (article in Chinese with English abstract)

参编专著

  1. 米文丽、毛应启梁、王彦青,癌痛的实验研究和病理机制。成文武主编,科学技术文献出版社,2021,23-36.

  2. 毛应启梁,疼痛的发生机制。急性和慢性手术后疼痛诊疗技术,顾卫东、陆智杰、王爱忠主编,天津科学技术出版社,2019

  3. Qi-Liang Mao-Ying, Wen-Li Mi. Acupuncture Analgesia in Clinical Practice. 针刺治疗神经生物学研究,Ying Xia, Xiaoding Cao, Gencheng Wu, Jieshi Cheng主编.2009, 162-193.(英文专著)


联系方式
Email: maoyql@fudan.edu.cn
电话: 021-54237611
传真: 021-54237526
通讯地址:上海市医学院路138号复旦大学基础医学院中西医结合学系291信箱(邮编200032)


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