中文 ENGLISH

汪 军

发表时间:2022-02-25 阅读次数:6788

博士、教授、硕士生导师、教学秘书、研究生培养秘书
 

研究方向:

     针刺与中药改善神经退行性疾病的神经免疫机制    

 

  

 

学习和工作简历

   1996年毕业于上海医科大学获学士学位,2005年获复旦大学中西医结合基础硕士学位,2009年获复旦大学中西医结合基础博士学位。2007-2008年作为访问学者在美国Illinois Institute of Technology和Blood Center of Wisconsin进修,2013-2014年作为高级访问学者到哈佛大学医学院Dana-Farber Cancer Institute访学。

    主要研究内容为中枢胶质细胞在神经系统损伤中的作用机制及中西医结合防治脱髓鞘疾病的效应和免疫调节机制,研究工作曾获得国家自然科学基金、上海市科委创新性行动计划、国家攀登计划、“973”计划、国家重点研发计划等多项国家级与省部级基金资助,以通讯作者和第一作者在Signal Transduction & Target Therapy ,Cell Death & Differentiation, PNAS, J Neuroinflammation, Oncogene等SCI杂志发表论文二十余篇,申请发明专利两项。担任Signal Transduction & Target Therapy,Advanced Science, Glia, Acta Pharmaceutica Sinica,CNS Neurosci Ther、Clin Exp Immunol等SCI杂志审稿人在阐明中枢胶质细胞在脱髓鞘疾病发病机制方面取得了许多重要的研究进展。2010年获得中国针灸学会科学技术三等奖,2016获中西医结合学会科技进步二等奖。任中国针灸学会电针专业委员会委员、中国心胸血管麻醉学会围术期基础与转化医学分会、上海市免疫学会中医药专业委员会委员。


科研项目:

国家自然科学基金面上项目:2021.01-2024.12,55万,项目负责人

国家自然科学基金面上项目:2025.01-2028.12,51万,项目负责人


近年来通讯作者论著 (通讯作者*): 

1.     Wang D, Zhang T, Shao Q, Wu X, Zhao X, Zhang H, Wang Y, Sun J, Chang X, Zhu K, Wu S, Cao L*, Chen W*, Wang J*. GSDME-mediated pyroptosis in microglia exacerbates demyelination and neuroinflammation in multiple sclerosis: insights from humans and cuprizone-induced demyelination model mice. Cell Death Differ. 2025 Jun 25. doi: 10.1038/s41418-025-01537-0

2.     Wang DJ, Wang X, Li SL, Zhang TT, Yang YC, Wang YM, Zhao XQ, Li KY, Wang YQ, Li Y, Zhu KY*, Wang J*. Sanguinarine modulates microglial function via PPARγ activation and protects against CNS demyelination. Int Immunopharmacol. 2024 Jan 25;127:111408.

3.     Gao SJ, Shen RL, Li J, Jiang Y, Sun H, Wu XY, Li XY, Miao CH, He M*, Wang J*, Chen WK*. N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABABR1 mRNA in sepsis-associated encephalopathy. Proc Natl Acad Sci U S A. 2024 Sep 3;121(36):e2410564121.

4.     Chen Z, Zhang J, Gao S, Jiang Y, Qu M, Gu J, Wu H, Nan K, Zhang H, Wang J*, Chen WK*, Miao CH*. Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2. Cell Mol Life Sci. 2024 Jul 30;81(1):325.

5.     Wang YM, Sun JX, Zhu KY, Wang DJ, Zhao XQ, Zhang HY, Wu S, Wang YQ*, Wang J*. Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination. J Neuroinflammation. 2023 Mar 25;20(1):83.

6.     Sun JX, Zhu KY, Wang YM, Wang DJ, Zhang MZ, Sarlus H, Benito-Cuesta I, Zhao XQ, Zou ZF, Zhong QY, Feng Y, Wu S, Wang YQ, Harris RA*, Wang J*. Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function. Acta Pharmacol Sin. 2023 Apr;44(4):766-779.(封面文章)

7.     Chang X, Jiao K, Wang D, Zhou Y, Zhao Z, Xing Y, Zhangbao J, Lu C, Wang J*, Quan C*. The immune imbalance between follicular regulatory and helper T cells in myelin oligodendrocyte glycoprotein IgG-associated disease. Clin Immunol. 2023 Oct;255:109734.

8.     Gao S, Jiang Y, Chen Z, Zhao X, Gu J, Wu H, Liao Y, Sun H, Wang J*, Chen WK*. Metabolic Reprogramming of Microglia in Sepsis-Associated Encephalopathy: Insights from Neuroinflammation. Curr Neuropharmacol. 2023;21(9):1992-2005.

9.     Lu YT, Sun Y, Peng Y, Zhao XQ, Wang DJ, Zhang TT, Qian F*, Wang J*. Inhibition of gasdermin D (GSDMD) as a promising therapeutic approach for atopic dermatitis. Int Immunopharmacol. 2023 Nov;124(Pt B):110958.

10.  Jiang Y, Gao S, Chen Z, Zhao X, Gu J, Wu H, Liao Y, Wang J*, Chen W*. Pyroptosis in septic lung injury: Interactions with other types of cell death. Biomed Pharmacother. 2023;169:11591.

11.  Zhang H, Wang D, Sun J, Wang Y, Wu S*, Wang J* Huperzine-A Improved Animal Behavior in Cuprizone-Induced Mouse Model by Alleviating Demyelination and Neuroinflammation. Int J Mol Sci. 2022 Dec 19;23(24):16182.

12.  Chen Y, Sun JX, Chen WK, Wu GC, Wang YQ, Zhu KY*, Wang J*. miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation. Signal Transduct Target Ther2019 Aug 16;4:27.https://doi.org/10.1038/s41392-019-0061-x

 

联系方式 
Email:jwangf@shmu.edu.cn
电话: 021-54237526
通讯地址:上海市医学院路138号,复旦大学基础医学院中西医结合系291信箱,200032

复旦大学基础医学院中西医结合学系 copyright © 2014

地址:上海市徐汇区医学院路138号