Bei Li
Ph.D., Associate Professor
Research Interests:
1. Pathogenesis, diagnosis and treatment of neurodegenerative diseases.
2. Application of automatic high throughput screening in disease research and drug development
The research has been focused on the pathogenesis, diagnosis and treatment of prion disease and its related neurodegenerative diseases. Graduated from the Institute of Molecular Life Sciences, University of Zurich, Switzerland. Participated in projects supported by Swiss National Science Foundation and European Research Council Advanced Research Grant etc. Afterwards, completed the postdoctoral work in the School of Basic Medical Sciences of Fudan University and received China Postdoctoral Science Foundation First class. Now, responsible for projects supported by the National Natural Science Foundation of China (Youth Fund), the talent introduction grant of Fudan University. Participate in the projects supported by the National Natural Science Fund of China (General Program) and Shanghai Talent Program, etc.
Education and Work Experience:
2022.02 - Now Associate Professor, Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, China
2019.10 – 2022.01 Postdoctoral Fellow, Department of Neurology, School of Basic Medical Sciences, Fudan University, China
2011.04 – 2017.02 Doctor of Natural Science, Institute of Molecular Life Sciences, University of Zurich, Switzerland
2010.01 – 2011.03 Research assistant, Institute of Neuropathology, University Hospital of Zurich, Switzerland
2005.09 – 2008.03 Master of Science in Biochemistry and Molecular Biology, Tongji University, China
2001.09 – 2005.06 Bachelor of Science in Biology Science and Technology, Yangzhou University, China
Publications:
1. Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu. The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine (Berlin, Germany). 2021; 99(6), 877–887.
2. Bei Li#, Meiling Chen#, Caihong Zhu.Neuroinflammation in Prion Disease. International Journal of Molecular Sciences. 2021;22(4), 2196.
3. Caihong Zhu#, Bei Li#, Karl Frontzek, Yingjun Liu, Adriano Aguzzi. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. The Journal of Experimental Medicine. 2019; 216(4), 743–756.
4. Marian Hruska-Plochan#, Bei Li#, Diego Kyburz, Jan Krützfeld, Ulf Landmesser, Adriano Aguzzi, Magdalini Polymenidou. New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases.Swiss Medical Weekly. 2015;145, w14192.
5. Caihong Zhu, Zhihao Li, Bei Li, Manuela Pfammatter, Simone Hornemann, Adriano Aguzzi. Unaltered prion disease in mice lacking developmental endothelial locus-1. Neurobiology of Aging. 2019; 76, 208–213.
6. Uli S Herrmann, Anne K Schütz, Hamid Shirani, Danzhi Huang, Dino Saban, Mario Nuvolone, Bei Li, Boris Ballmer, Andreas K O Åslund, Jeffrey J Mason, Elisabeth Rushing, Herbert Budka, Sofie Nyström, Per Hammarström, Anja Böckmann, Amedeo Caflisch, Beat H Meier, K Peter R Nilsson, Simone Hornemann, Adriano Aguzzi. Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine. 2015; 7(299), 299ra123.
7. Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of Aging. 2015; 36(5), 1994–2003.
8. Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathogens. 2015; 11(2), e1004662.
9. Tiziana Sonati, Regina R Reimann, Jeppe Falsig, Pravas Kumar Baral, Tracy O'Connor, Simone Hornemann, Sine Yaganoglu, Bei Li, Uli S Herrmann, Barbara Wieland, Mridula Swayampakula, Muhammad Hafizur Rahman, Dipankar Das, Nat Kav, Roland Riek, Pawel P Liberski, Michael N G James, Adriano Aguzzi. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013; 501(7465), 102–106.
10. Jeppe Falsig, Tiziana Sonati, Uli S Herrmann, Dino Saban, Bei Li, Karina Arroyo, Boris Ballmer, Pawel P Liberski, Adriano Aguzzi. Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. PLoS Pathogens. 2012; 8(11), e1002985.
Address:
Email: beili@fudan.edu.cn
Address: 130 Dong An Road, Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, China
Post code: 200032