Qi-Liang Mao-Ying
Ph.D., Associate Professor
1.Neurobiological mechanisms underlie electro-acupuncture (EA) analgesia on chronic pain
The aim is to investigate the role of neuroinflammation in chronic pain, and the analgesic effects of EA on chronic pain. The work focuses on the unique spinal inflammatory state induced by complex factors rather than inflammatory and neuropathic pain contributes to cancer pain and EA analgesia.
2.The role of EA on chemotherapy induced peripheral neuropathy and its mechanisms
The aim is to investigate the mechanisms underlie chemotherapy induced peripheral neuropathy, especially chemotherapy induced numbness, and to observe the neuroprotective effects of EA on chemotherapy induced peripheral neuropathy.
Education and Work Experience:
2014.12- Associate Professor, Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, China
2012.8-2013.11，Postdoctoral Fellow, Department of Symptom Research, MD Anderson Cancer Center, TX US
2011.11-2012.8，Postdoctoral Fellow, Department of Animal Science, University of Illinois at Urbana-Champaign, Illinois US
2007.7-, Assistant Professor, Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, China
2002.9-2007.7, Ph.D., Integrative Medicine and Neurobiology, Shanghai Medical College of Fudan University, China
1997.9-2002.7, Bachelor’s Degree, Basic Medical Science, Shanghai Medical College of Fudan University (Former Shanghai Medical University), China
Publications:
1. Yu Chen #, Yang Zhou #, Xiao-Chen Li, Xue Ma, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice. Biol Res. 2022, 55(1):5.
2. Xue Ma, Yu Chen, Xiao-Chen Li, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Spinal Neuronal GRK2 Contributes to Preventive Effect by Electroacupuncture on Cisplatin-Induced Peripheral Neuropathy in Mice. Anesth Analg. 2022, 134(1): 204-215.
3. Hu LY, Mi WL, Wu GC, Wang YQ, Mao-Ying QL*. Prevention and Treatment for Chemotherapy-Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms. Curr Neuropharmacol. 2019,17(2):184-196. （Review）
4. Hu LY, Yang-Zhou, Cui WQ, Hu XM, Du LX, Mi WL, Chu YX, Wu GC, Wang YQ, Mao-Ying QL*. Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice. Brain Behav Immun. 2018, 68: 132-145.
5. Liu H, Liu SB, Li Q, Wang H, Wang YQ, Mao-Ying QL*. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evid Based Complement Alternat Med. 2015:848603.
6. Mao-Ying QL, Kavelaars A, Krukowski K, Huo XJ, Zhou W, Price TJ, Cleeland C, Heijnen CJ. The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model. PLoS One. 2014, 23;9(6):e100701
7. Li X, Wang XW, Feng XM, Zhou WJ, Wang YQ, Mao-Ying QL*, Stage-dependent anti-allodynic effects of intrathecal Toll-like receptor 4 antagonists in a rat model of cancer induced bone pain. J Physiol Sci. 2013, 63(3):203-9.
8. Mao-Ying QL, Wang XW, Yang CJ, Li X, Mi WL, Wu GC, Wang YQ. Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats. Mol Brain. 2012, 5:16.
9. Yang CJ, Li Q, Wu GC, Wang YQ, Mao-Ying QL*. A practical model of osteomyelitis-induced bone pain by intra-tibial injection of Staphylococcus aureus in rats. Neurosci Lett. 2012, 513(2):198-203.
10. Yang CJ, Wang XW, Li X, Wu GC, Wang YQ, Mao-Ying QL*. A rat model of bone inflammation-induced pain by intra-tibial complete Freund's adjuvant injection. Neurosci.Lett. 2011, 490(3):175-9.
11. Qi-Liang Mao-Ying, Jun Zhao, Zhi-Qiang Dong, Jun Wang, Jin Yu, Min-Fen Yan, Yu-Qiu Zhang, Gen-Cheng Wu, Yan-Qing Wang. A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells. Biochemical and Biophysical Research Communication. 2006, 345: 1292-1298.
12. Qi-Liang Mao-Ying, Ke-Mi Cui, Qiong Liu, Zhi-Qiang Dong, Wei Wang, Jun Wang, Hong Sha, Gen-Cheng Wu, Yan-Qing Wang. Stage-dependent analgesia of electro-acupuncture in a mouse model of cutaneous cancer pain. European Journal of Pain. 2006, 10(8): 689-94.
13. Shan Sun, Qi-Liang Mao-Ying, Hong Cao, Tingting Li, Mei Han, Haili Pan, Yan-Qing Wang, Zhi-Qi Zhao and Yu-Qiu Zhang. Is functional state of spinal microglia involved in the anit-allodynic and anti-hyperalgesic effects of electroacupuncture in rat model of monoarthritis? Neurobiology of Disease. 2007, 26(3): 558-68.
14. Qi-Liang Mao-Ying, Dian-Huan Ren, Wen-Li Mi, Qiong Liu, Yan-Qing Wang. Analgesic effects of electroacupuncture combined with Celebrex on rats with tibial cancer pain. Journal of Chinese Integrative Medicine. 2008, 6(8): 830-835. (article in Chinese with English abstract)
Books:
1.Qi-Liang Mao-Ying, Wen-Li Mi. Acupuncture Analgesia in Clinical Practice. Acupuncture Therapy on Neurological Diseases: A Neurobiological View. Springer Publication House (Springer & Tsinghua Publication House)，editor: Ying Xia, Xiaoding Cao, Gencheng Wu, Jieshi Cheng.2010, 162-193.
Address:
P.O.Box 291, 138 Yi-Xue-Yuan Road
Department of Integrative Medicine and Neurobiology
School of Basic Medical Sciences, Fudan University
Shanghai, 200032
People's Republic of China
Email: maoyql@fudan.edu.cn
Tel: +86-021-54237611
Fax: +86-021-54237526