Qi-Liang Mao-Ying
Ph.D., Associate Professor
1.Neurobiological mechanisms underlie electro-acupuncture (EA) analgesia on chronic pain
The aim is to investigate the role of neuroinflammation in chronic pain, and the analgesic effects of EA on chronic pain. The work focuses on the unique spinal inflammatory state induced by complex factors rather than inflammatory and neuropathic pain contributes to cancer pain and EA analgesia.
2.The role of EA on chemotherapy induced peripheral neuropathy and its mechanisms
The aim is to investigate the mechanisms underlie chemotherapy induced peripheral neuropathy, especially chemotherapy induced numbness, and to observe the neuroprotective effects of EA on chemotherapy induced peripheral neuropathy.
Education and Work Experience:
2014.12- Associate Professor, Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, China
2012.8-2013.11，Postdoctoral Fellow, Department of Symptom Research, MD Anderson Cancer Center, TX US
2011.11-2012.8，Postdoctoral Fellow, Department of Animal Science, University of Illinois at Urbana-Champaign, Illinois US
2007.7-, Assistant Professor, Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, China
2002.9-2007.7, Ph.D., Integrative Medicine and Neurobiology, Shanghai Medical College of Fudan University, China
1997.9-2002.7, Bachelor’s Degree, Basic Medical Science, Shanghai Medical College of Fudan University (Former Shanghai Medical University), China
Publications:
1. Chieh-Ru Fu, Xiao-Chen Li, Ya-Chen Yang, Hui Chen, Ruo-Fan Zhang, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Spinal dorsal horn IGF1 mediates the preventive effect of electroacupuncture on cisplatin-induced peripheral neuropathy via neuronal IGF1R in mice. Chin Med. 2025, 20(1):201.
2. Chieh-Ru Fu, Jia-Hao Chen, Ya-Chen Yang, Hui Chen, Ruo-Fan Zhang, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Targeting Upregulation of Neuronal IGF1/IGF1R Signalling in the Spinal Cord Prevents Cisplatin-Induced Peripheral Neuropathy in Mice. Eur J Pain. 2025, 29:e70161.
3. Xiao-Chen Li, Hui Chen, Yu Chen, Yu-Xia Chu , Wen-Li Mi, Yan-Qing Wang, Qi-Liang Mao-Ying*. Spinal Neuronal miR-124 Inhibits Microglial Activation and Contributes to Preventive Effect of Electroacupuncture on Chemotherapy-Induced Peripheral Neuropathy in Mice. J Immunol. 2024, 212(3):410-420.
4. Yu Chen#, Yang Zhou#, Xiao-Chen Li, Xue Ma, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice. Biol Res. 2022, 55(1):5.
5. Yu Chen, Hui Chen, Xiao-Chen Li, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Neuronal toll like receptor 9 contributes to complete Freund's adjuvant-induced inflammatory pain in mice. Front Mol Neurosci. 2022, 15: 1008203.
6. Xue Ma, Yu Chen, Xiao-Chen Li, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang, Qi-Liang Mao-Ying*. Spinal Neuronal GRK2 Contributes to Preventive Effect by Electroacupuncture on Cisplatin-Induced Peripheral Neuropathy in Mice. Anesth Analg. 2022, 134(1): 204-215.
7. Hu LY, Mi WL, Wu GC, Wang YQ, Mao-Ying QL*. Prevention and Treatment for Chemotherapy-Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms. Curr Neuropharmacol. 2019,17(2):184-196. （Review）
8. Hu LY, Yang-Zhou, Cui WQ, Hu XM, Du LX, Mi WL, Chu YX, Wu GC, Wang YQ, Mao-Ying QL*. Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice. Brain Behav Immun. 2018, 68: 132-145.
9. Liu H, Liu SB, Li Q, Wang H, Wang YQ, Mao-Ying QL*. Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evid Based Complement Alternat Med. 2015:848603.
10. Mao-Ying QL, Kavelaars A, Krukowski K, Huo XJ, Zhou W, Price TJ, Cleeland C, Heijnen CJ. The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model. PLoS One. 2014, 23;9(6):e100701
11. Li X, Wang XW, Feng XM, Zhou WJ, Wang YQ, Mao-Ying QL*, Stage-dependent anti-allodynic effects of intrathecal Toll-like receptor 4 antagonists in a rat model of cancer induced bone pain. J Physiol Sci. 2013, 63(3):203-9.
12. Mao-Ying QL, Wang XW, Yang CJ, Li X, Mi WL, Wu GC, Wang YQ. Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats. Mol Brain. 2012, 5:16.
13. Yang CJ, Li Q, Wu GC, Wang YQ, Mao-Ying QL*. A practical model of osteomyelitis-induced bone pain by intra-tibial injection of Staphylococcus aureus in rats. Neurosci Lett. 2012, 513(2):198-203.
14. Yang CJ, Wang XW, Li X, Wu GC, Wang YQ, Mao-Ying QL*. A rat model of bone inflammation-induced pain by intra-tibial complete Freund's adjuvant injection. Neurosci.Lett. 2011, 490(3):175-9.
15. Qi-Liang Mao-Ying, Jun Zhao, Zhi-Qiang Dong, Jun Wang, Jin Yu, Min-Fen Yan, Yu-Qiu Zhang, Gen-Cheng Wu, Yan-Qing Wang. A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells. Biochemical and Biophysical Research Communication. 2006, 345: 1292-1298.
16. Qi-Liang Mao-Ying, Ke-Mi Cui, Qiong Liu, Zhi-Qiang Dong, Wei Wang, Jun Wang, Hong Sha, Gen-Cheng Wu, Yan-Qing Wang. Stage-dependent analgesia of electro-acupuncture in a mouse model of cutaneous cancer pain. European Journal of Pain. 2006, 10(8): 689-94.
17. Qi-Liang Mao-Ying, Dian-Huan Ren, Wen-Li Mi, Qiong Liu, Yan-Qing Wang. Analgesic effects of electroacupuncture combined with Celebrex on rats with tibial cancer pain. Journal of Chinese Integrative Medicine. 2008, 6(8): 830-835. (article in Chinese with English abstract)
Books:
1. Qiliang Maoying, Yu Chen, and Xiaochen Li. Alternative Therapies for Chemotherapy-Induced Peripheral Neuropathy. Advanced Acupuncture Research: From Bench to Bedside,Ying Xia Editor. Springer Cham. 2022, 401-446.
2. Qi-Liang Mao-Ying, Wen-Li Mi. Acupuncture Analgesia in Clinical Practice. Acupuncture Therapy on Neurological Diseases: A Neurobiological View. Springer Publication House (Springer & Tsinghua Publication House)，editor: Ying Xia, Xiaoding Cao, Gencheng Wu, Jieshi Cheng.2010, 162-193.
Address:
P.O.Box 291, 138 Yi-Xue-Yuan Road
Department of Integrative Medicine and Neurobiology
School of Basic Medical Sciences, Fudan University
Shanghai, 200032
People's Republic of China
Email: maoyql@fudan.edu.cn
Tel: +86-021-54237611
Fax: +86-021-54237526