Yi Feng
Yi Feng, Ph.D. & M.D.
RESEARCH INTERESTS
• Effect and mechanism study of acupuncture on gynecological diseases.
• Tissue clearing and 3D imaging
RESEARCH EXPERIENCE
Stanford University 2013-2016
Visiting Associate Professor with Prof. Aaron J.W. Hsueh
Project: Follicular development and ovulation
Fudan University 2009-
Assistant Professor, Associate Professor, Professor
Project: Effect of electro-acupuncture on central nervous system in transgenic mice with polycystic ovary syndrome
Gothenburg University 2008-2009
Visiting Scholar with Prof. Elisabet Stener-Victorin
Project: Effect of electro-acupuncture on skeletal muscle insulin sensitivity, on adipose tissue cellularity and on central nervous system in adult female rats with dihydrotestosterone induced polycystic ovary syndrome
Fudan University 2006-2008
Postdoctoral Fellow with Professor Zhang, Yu-qiu
Project: The Conduction Pathways of “Guanyuan”(CV 4) Area---A Pseudorabies Virus Neural Tracing Study
Fudan University 2003-2006
Doctoral Research, Research Assistant with Professor Chen, Bo-ying
Project: Role of Brain PrRP in Electroacupuncture Normalizing the Dysfunction of Hypothalamus-pituitary-ovarian Axis and Regulation of Oestrous Cycle in Female Rats
Hubei University of TCM 2000- 2003
Graduate Research with Professor Li, Lie-rong
Project: The Experimental Research on Postmenopausal Osteoporosis by GNAT Tablet
Publications:
1. 第一作者论文
(1) Liang Chen(#), Yi Feng(#), Jia Tang(#) , Wei Hu1 , Ping Zhao3,5 , Xiaoxiao Guo1 , Ninghao Huang3,5 , Yuwei Gu1 , Linjie Hu3,5 , Firat Duru6,7*, Chenglong Xiong3,5* and Mingquan Chen1*. Surface electrocardiographic characteristics in coronavirus disease 2019: repolarization abnormalities associated with cardiac involvement. ESC HEART FAILURE. 2020 Sep 8. doi: 10.1002/ehf2.12991
(2) Feng, Yi(#)， Zhu, Shoujun(#)， Antaris, Alexander L. (#)， Chen, Hao， Xiao, Yuling， Lu, Xiaowei， Jiang, Linlin， Diao, Shuo， Yu, Kuai， Wang, Yan， Herraiz, Sonia， Yue, Jingying， Hong, Xuechuan， Hong, Guosong， Cheng, Zhen(*) ， Dai, Hongjie(*) ， Hsueh, Aaron J. (*) Live imaging of follicle-stimulating hormone receptors in gonads and bones using near-infrared II fluorophore， Chemical Science，2017.5.01，8（5）：3703~3711
(3) Feng Y. (#)(*)， Cui P.， Lu X.， Hsueh B.， Möller Billig F.， Zarnescu Yanez L.， Tomer R.， Boerboom D.， Carmeliet P.， Deisseroth K.， Hsueh A.J.W. (*)， CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions， Scientific Reports，2017,7:44810
(4) Yi Feng (#)，Shien Zou (#) ，Birgitta Weijdegård，Jie Chen，QingCong，Julia Fernandez-Rodriguez，Lei Wang，Håkan Billig，Ruijin Shao(*)。The onset of human ectopic pregnancy demonstrates a differential expression of miRNAs and their cognate targets in the Fallopian tube， Int J Clin Exp Pathol，2014.1.1，7（1）：64~79
(5) Feng Y(#)，Johansson J，Shao R，Manneras-Holm L，Billig H，Stener-Victorin E (*)。 Electrical and manual acupuncture stimulation affects estrous cyclicity and neuroendocrine function in rats with DHT-induced polycystic ovary syndrome， Experimental Physiology，2012.01.01，97（5）：651~662
(6) Feng, Yi(#)，Shao, Ruijin(#)(*)，Weijdegard, Birgitta，Wang, Tienpei，Johansson, Julia，Sun, Shan，Wang, Wei，Egecioglu, Emil，Billig, Hakan，Stener-Victorin, Elisabet (*). Effects of androgen and leptin on behavioral and cellular responses in female rats， Hormones and Behavior，2011.9 .01，60（4）：427~438
(7) Feng, Yi(#)，Li, Xin，Shao, Ruijin (*). Genetic modeling of ovarian phenotypes in mice for the study of human polycystic ovary syndrome， AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH，2013.01.01，5（1）：15~20
(8) Feng, Yi(#)，Johansson, Julia，Shao, Ruijin，Manneras, Louise Fernandez-Rodriguez, Julia，Billig, Hakan，Stener-Victorin, Elisabet(*). Hypothalamic Neuroendocrine Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome: Effects of Low-Frequency Electro-Acupuncture， PLos One，2009.8.14，4（8）：6638~6638
(9) Feng, Yi(#)，Weijdegard, Birgitta，Wang, Tienpei，Egecioglu, Emil，Fernandez-Rodriguez, Julia，Huhtaniemi, Ilpo，Stener-Victorin, Elisabet，Billig, Hakan，Shao, Ruijin(*)。Spatiotemporal expression of androgen receptors in the female rat brain during the oestrous cycle and the impact of exogenous androgen administration: A comparison with gonadally intact males. Molecular and Cellular Endocrinology，2010.6.10，321（2）：161~174
(10) Feng, Yi(#)(*)， Lin, Huagang (#)， Zhang, Yin， Li, Lierong， Wu, Xuping， Wang, Tienpei， Liu, Youxiang， Tan, Yilun， Electroacupuncture Promotes Insulin-Like Growth Factors System in Ovariectomized Osteoporosis Rats， American Journal of Chinese Medicine，2008.01.01，36（5）：889~897
(11) Feng, Yi(#)， Zhao, Hong， An, Xiao-Fei， Ma, Su-Lan， Chen, Bo-Ying(*). Expression of brain prolactin-releasing peptide (PrRP) changes in the estrous cycle of female rats， Neuroscience Letters，2007.5.23，419（1）：38~42
(12) 冯异 (#)，马淑兰，陈伯英(*)。脑内催乳素释放肽参与电针对围绝经期综合征大鼠下丘脑-垂体-卵巢轴异常功能的调整，针刺研究，2006.8.25，（04）：195~199
(13) 冯异(#)(*)，黎烈荣，张英，刘又香. 更年安怡片对绝经后骨质疏松雌鼠防治作用的实验研究，中国骨质疏松杂志，2008.2.20（02）：85~89
2. 通讯作者论文（勿与第一作者论文重复）
(1) Wenhan Lu, Zhenle Pei，Wei Hu, Chen Tan, Xiaoyu Tong , Yi Feng *，Xinghuai Sun **. Recent progress in optical clearing of eye tissues. Experimental Eye Research 212 (2021) 108796
(2) 祁琴，童小雨，吴璐一，吴楚婷，赵继梦，黄艳，李昆珊，马晓芃，王照钦，冯异*，吴焕淦*. 透明化三维成像研究艾灸对结肠炎大鼠肠道血管生成的作用. 上海针灸杂志. https://doi.org/10.13460/j.issn.1005-0957.2021.13.0018
(3) Feifei Zhang1,2*, Tong Ma3*, Xiaoyu Tong3*, Yanjun Liu3, Peng Cui3, Xiaoqing Xu3, Jiemei Shi3, Wei Hu3, Wenhan Lu3, Zhenle Pei3, Minzhen Xu3, Xin Li1,2, Congjian Xu1,2 and Yi Feng. Electroacupuncture improves metabolic and ovarian function in a rat model of polycystic ovary syndrome by decreasing white adipose tissue, increasing brown adipose tissue, and modulating the gut microbiota. Acupuncture in Medicine 1–13DOI: 10.1177/09645284211056663
(4) Cui P†, Shi JM†, Ma T, Rao L, Tong XY, Hu W, Xu XQ, Zhang FF, Li X, Billig H, Shao LR, Feng Y*. Long-term androgen-induced nonalcoholic fatty liver disease in a polycystic ovary syndrome mouse model is related to mitochondrial dysfunction. ReprodDev Med2021;5:71-80.
(5) WeiHu†, Junda Chen†, Caixia Sun†, Xiaoyu Tong,Wenhan Lu, Ziyong Ju, Yong Xia, Zhenle Pei1, Mingzhen Xu, Xiaoqing Xu, Jiemei Shi, Yi Li, Haofeng Chen, Yizhou Lu, Ying Ying, Hongru Gao, Aaron J.W. Hsueh, Fan Zhang, Zhi Lü,*, Yi Feng*.Spatial topological analysis of the sympathetic neurovascular characteristic of acupoints in the Ren meridian using advanced tissue-clearing and near-infrared II imaging. Computational and Structural Biotechnology Journal. 2021. https://doi.org/10.1016/j.csbj.2021.04.010 8;19:2236-2245
(6) PengCui †, WeiHu†, TongMa, MinHu, XiaoyuTong, FeifeiZhang, Jiemei Shi , XiaoqingXu, XinLi,HåkanBillig*,Yi Feng*. Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats. Journal of Steroid Biochemistry and Molecular Biology 208 (2021) 105829
(7) Xiaoyu Tong, Yanjun Liu，Xiaoqing Xu, Jiemei Shi, Wei Hu, Tong Ma, Peng Cui, Wenhan Lu, Zhenle Pei, Mingzhen Xu, Feifei Zhang, Xin Li, and Yi Feng*. Ovarian Innervation Coupling With Vascularity: The Role of Electro-Acupuncture in Follicular Maturation in a Rat Model of Polycystic Ovary Syndrome. Front. Physiol., 29 May 2020 https://doi.org/10.3389/fphys.2020.00474
(8) Yu-Xia Chu,†, Ming Gao†, Hai-Feng Gao, Ye Liu, Xun-Jia Cheng, Rui-Zhe Qian, Xiang-Feng Zhou, and Yi Feng*. Current status of international medical education in China: A cross-sectional study. Traditional Medicine and Modern Medicine. 2019; 2(2): 75-84
(9) Feifei Zhang, Tong Ma, Peng Cui, Amin Tamadon, Shan He, Chuanbing Huo,Gulinazi Yierfulati, Xiaoqing Xu, Wei Hu, Xin Li, Linus R. Shao, Hongwei Guo,Yi Feng* and Congjian Xu*. Diversity of the Gut Microbiota in dihydrotestosterone-Induced PCOSRats and the Pharmacologic Effectsof Diane-35, Probiotics, and berberine.Frontiers in Microbiology.February 2019 | Volume 10 | Article 175
(10) Tong Ma†, Peng Cui†, Xiaoyu Tong, Wei Hu, Linus R. Shao, Feifei Zhang,Xin Li,* and Yi Feng*. Endogenous Ovarian Angiogenesis in PolycysticOvary Syndrome-Like Rats Induced by low-Frequency Electro-Acupuncture: The CLARITYThree-Dimensional Approach. International Journal of Molecular Sciences. 2018, 19, 3500; doi:10.3390/ijms191135004.183
(11) Peng Cui, Tong Ma, Amin Tamadon, Sha Han, Bing Li, Zheyi Chen, Xiaofei An, Linus R. Shao, Yanqing Wang, Yi Feng(*).Hypothalamic DNA methylation in rats with dihydrotestosterone-induced polycystic ovary syndrome: effects of low-frequency electro-acupuncture. Experimental Physiology. 2018;103:1618–1632.
(12) Amin Tamadon#, Wei Hu#, Peng Cui, Tong Ma, Xiaoyu Tong, Feifei Zhang, Xin Li, Linus R. Shao and Yi Feng*.How to choose a suitable animal model of polycystic ovary syndrome? Traditional Medicine and Modern Medicine.Vol. 1, No. 2 (2018) :95-113
(13) Feng Y(*), Tamadon A, Hsueh AJW(*).Imaging the ovary. Reprod Biomed Online. 2018
May;36(5):584-593.
(14) Wenli Zhang(#), Shaohua Liu(#), Weichen Zhang(#),Wei Hu(#), Min Jiang, Amin Tamadon(*), Yi Feng(*). Skeletal muscle CLARITY: a preliminary study for imaging of three-dimensional architecture of blood vessels and neurons. Cell J. 2018;(20)2:132-137
(15) Na Xu (#), Amin Tamadon (#), Yaan Liu (#), Tong Ma, Rehana K. Leak, Jun Chen, Yanqin Gao (*) & Yi Feng(*). Fast free-of-acrylamide clearing tissue (FACT)—an optimized new protocol for rapid, high-resolution imaging of three-dimensional brain tissue. Scientific Reports. 2017. 7: 9895 | DOI:10.1038/s41598-017-10204-5
(16) Wei Hu(#), Amin Tamadon, Aaron J.W. Hsueh, Yi Feng(*). Three-Dimensional reconstruction of the vascular architecture of the Passive CLARITY mouse ovary using Imaris software. J Vis Exp. 2017 Dec 10;(130). doi: 10.3791/56141
(17) Xiong WX (#)， Lin Y(#)， Xu LL (#)， Tamadon A(#)， Zou SE， Tian FB， Shao R， Li X (*)， Feng Y(*). Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population， Journal of ovarian research，2017.10.10.
(18) Wang, Xun(#) ， Huang, Yongheng(#) ， Yuan, Shiwen(#) ， Tamadon, Amin(#) ， Ma, Shulan， Feng, Yi (*)， The Role of Hippocampal Estradiol Receptor-alpha in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture， Evidence-Based Complementary and Alternative Medicine，2016.4958312
(19) Junting Hu(#) ，Sulan Ma(#)，Sien Zou，Xin Li，Peng Cui，BirgittaWeijdegård，Gencheng Wu，Håkan Billig(*) ，Ruijin Shao，Yi Feng(*). The Regulation of Nitric Oxide Synthase Isoform Expression in，Int J Mol Sci，2014.12.23，16（0）：49~67
(20) Ma, Shulan， Wu, Jihong， Feng, Yi(*)， Chen, Boying(*). Elevated estrogen receptor expression in the hypothalamic preoptic area decreased by electroacupuncture in ovariectomized rats， Neuroscience Letters，2011.4.25，494（2）：109~113
(21) 张凤，冯异(*)，周瑞，张玉秋，陈伯英(*). 正常和病理状态下“关元”穴的中枢神经束路示踪研究及电针的影响，针刺研究，2008.6.25，（03）：147~153
(22) 许婷，李昕，冯异(*). 多囊卵巢综合征转基因动物模型的研究进展.基础医学与临床，2013.01.01，33（1）：119~122
Address:
138 Yixueyuan Rd, Box291
Department of Integrative Medicine and Neurobiology
Shanghai Medical College of Fudan University
Shanghai, China, 200032
E-mail: fengyi17@fudan.edu.cn.
Telephone: +86-21-54237693