系简介

师资风采

黄志力


复旦大学特聘教授、博士生导师，国家杰出青年科学基金获得者、上海市领军人才、上海市优秀学科带头人，国务院特殊津贴专家。1992、1997年二次获笹川医学奖学金赴日本留学；1999年获博士学位。1999年起任日本学术振兴会JSPS博士后、大阪生命科学研究所研究员，研究副部长；2005年12月加盟复旦大学。现任基础医学院药理学系主任。

学会任职：中国睡眠研究会理事长、中国药理学会常务理事，麻醉药理学专委会候任主委、上海市药学会药理专业委员会副主任委员、中国神经科学会理事、Asian Society of Sleep Medicine常务理事、日本睡眠学会评议员。

学术期刊任职：《中国临床药理学与治疗学》主编，《Frontier in Neuroscience》《Sleep and Breathing》《Sleep Biol Rhythms》《世界睡眠医学杂志》《Sleep中文版》副主编，Acta Pharmacol Sin》《药学学报》《中国药理学通报》《中药药理与临床》《四川精神卫生》《神经药理学》和《生物物理学报》编委或常务编委等。

研究方向:神经精神药理学、睡眠觉醒调控机制、失眠动物模型和失眠机制、神经精神疾病治疗药物开发。

招生专业: 神经精神药理学、神经生物学。

基金项目：牵头科技创新2030国家脑计划重大项目，主持国家自然科学基金委项目（重点、国家杰出青年、重点国际合作、创新群体、面上项目等）、国家＂新药创制重大专项＂、上海市科委重点、重点攻关及优秀学科带头人等纵向项目。承担国内、外制药企业委托等横向科研项目。

论文发表：发表SCI研究论文150多篇，包括Nature Neuroscience, Light: Science & Applications, Nature Communications, Brain，PNAS，Progress in Neuroscience，Curreent Biology, PLos Biology，eLife, British Journal of Pharmacology, Neuropsychopharmacology，Journal of Neuroscience等国际著名学术期刊，累计影响因子700，2014-2019年连续上榜爱思唯尔（Elsevier）发布的中国学术论文高被引学者榜单。应邀为Trends Neurosci, Prog Neurobiol, Curr Opin Neurosci, Curr Opin Pharmacol等杂志撰写综述，为Nat Neurosci, PNAS, Curr Biol, J Neurosci, Neuropharmacology, Br J Pharmacol等30个SCI杂志审稿。


代表性论文（选自150篇SCI文章）：

  1.  Dong H, Chen ZK, Guo H, Yuan XS, Liu CW, Qu WM, Huang ZL*, Striatal Neurons Expressing Dopamine D1 Receptor Promote Wakefulness in Mice, Current Biology. 2022 Feb 7;32(3):600-613.e4. doi: 10.1016/j.cub.2021.12.026.

  2.  Li YD#, Luo YJ#, Xu W, Ge J, Cherasse Y, Wang YQ, Lazarus M, Qu WM*,Huang ZL*. Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway. Mol Psychiatry, 2021 Jul;26(7):2912-2928.

  3.  Bao WW, Xu W, Pan GJ, Wang TX, Han Y, Qu WM, Li WX, Huang ZL*. Nucleus accumbens neurons expressing dopamine D1 receptors modulate states of consciousness in sevoflurane anesthesia. Current Biology. 2021 May 10;31(9):1893-1902.e5. doi: 10.1016/j.cub.2021.02.011.

  4.  Chen CR*, Zhong YH, Jiang S, Xu W, Wang Z, Xiao L, Qu WM, Huang ZL*.Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice. Elife, 2021 Nov 17;10:e69909. doi: 10.7554/eLife.69909.

  5.  Yang YF, Dong H, Shen Y, Li L, Lazarus M, Qu WM, Huang ZL*. Mesencephalic dopaminergic neurons are essential for modafinil-induced arousal.Br J Pharmacol. 2021 Aug 16. doi: 10.1111/bph.15660. Online ahead of print.

  6.  Wang YQ, Liu WY, Li L, Qu WM, Huang ZL*. Neural circuitry underlying REM sleep: A review of the literature and current concepts. Progress in Neurobiology. 2021 Jun 15:102106. doi: 10.1016/j.pneurobio.2021.102106.

  7.  Shen Y, Yu WB, Shen B, Dong H, Zhao J,  Fan Y, Yang YF, Sun YM, Luo SS, Chen C, Liu FT, Tang YL, Wu JJ, Xiao BG, Yu H, Koprich JB, Huang ZL*, Wang J*. propagated alpha-synucleinopathy recapitulates RBD followed by Parkinsonian phenotypes in mice. Brain, 2020, 143; 3374–3392.

  8. Zhang Z, Liu WY, Diao YP, Xu W, Zhong YH, Zhang JY, Lazarus M, Liu YY, Qu WM*, and Huang ZL*. Superior colliculus GABAergic neurons are essential for acute dark-induction of wakefulness in mice. Current Biology, 2019 Feb 18; 29(4):637-644.

  9.  Luo YJ, Li YD, Wang L, Yang SR, Yuan XS, Wang J, Cherasse Y, Lazarus M, Chen JF, Qu WM*, and Huang ZL*. Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors.Nature Communications, 2018 Apr 20;9(1):1576. doi: 10.1038/s41467-018-03889-3.

  10.  Wu YE, Enoki R*, Oda Y, Huang ZL*, Honma K, Honma S. Ultradian Calcium Rhythms in the Paraventricular Nucleus and Subparaventricular Zone in the Hypothalamus. Proc Natl Acad Sci U S A. 2018; 115(40):E9469-E9478.

  11. Yang SR*, Hu ZZ, Luo YJ, Zhao YN, Sun HX, Yin D, Wang CY, Yan YD, Wang DY, Yuan XS, Ye CB, Guo W, Qu WM, Cherasse Y, Lazarus M, Ding YQ, Huang ZL*. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS Biology, 2018 Apr 13;16(4):e2002909. doi: 10.1371/journal.pbio.2002909.

  12. Yuan XS, Wang L, Dong H, Qu WM, Yang SY, Cherasse Y, Lazarus M, Schifmann S, de Kerchove d'Exaerde A, Li RX* and Huang ZL*. Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. eLife, 2017 Oct 12;6. pii: e29055. doi: 10.7554/eLife.29055.

  13. Oishi Y, Xu Q, Wang L, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schifmann S, de Kerchove d'Exaerde A, Urade Y, Qu WM, Huang ZL* and Lazarus M*. Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature Communications, 2017 Sep 29;8(1):734. doi: 10.1038/s41467-017-00781-4.

  14.  Zhang Z, Wang HJ, Wang DR, Qu WM* and Huang ZL*.Red light at intensities above 10 lx alters sleep-wake behavior in mice. Light: Science & Application, 2017 May 6; e16231; doi:10.1038/lsa.2016.231

  15. Oishi Y, Huang ZL*,Fredholmd BB, Uradea Y and Hayaishi O*. Adenosine in the tuberomammillary nucleus inhibitsthe histaminergic system via A1 receptors andpromotes non-rapid eye movement sleep. Proc Natl Acad Sci USA, 2008, 105(50):19992-19997.

  16. Qu WM, Huang ZL*, Xu XH, Matsumoto N and Urade Y. Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci 2008, 28(34): 8462-8469.

  17. Huang ZL, Mochizuki T, Qu WM, Hong ZY, Watanabe T, Urade Y and Hayaishi O. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci USA 2006, 103(12): 4687-4692.

  18. Qu WM, Huang ZL, Xu XH, Aritake K, Eguchi O, Nambu F, Narumiya S, Urade Y and Hayaishi O. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci USA, 2006; 103(47):17949-17954.

  19. Huang ZL, Qu WM, Eguchi, N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y and Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci 2005; 8(7): 858-859.

  20. Huang ZL, QuWM, LiWD, MochizukiM, EguchiN, WatanabeT, UradeY and HayaishiO. Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci USA2001; 98(17):9965-9970.

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