姓名:张醉
职称:青年副研究员
电话:021-54237379
电子邮箱:zhangzui@fudan.edu.cn
办公地点:上海市徐汇区东安路130西十三629
个人主页/课题组网页:无
教育经历:
2005.09—2009.09华中科技大学生物药学专业本科生
2009.09—2012.03华中科技大学基础医学药理专业硕士研究生
2012.10—2016.10日本名古屋大学分子生物学专业博士研究生
工作经历:
2016.10—2020.05复旦大学基础医学院博士后
2020.05—至今复旦大学基础医学院青年副研究员
获得奖项:
2021,优秀博士后,复旦大学
2019,百特医药青年论文奖一等奖,百特医药公司
2019,中国药剂学大会青年论文展报一等奖,中国药剂学大会
研究方向:
1. 脑部疾病领域:发病机制、药物治疗、基于体内功能化策略的脑靶向药物递送方式研究
2. 纳米制剂领域:高端纳米载体/基因疫苗的设计和体内过程研究
科研项目:
2022,国家自然科学基金面上项目, “基于双功能短链抗体片段的蛋白冠主动精准调控及生物学效应”, 主持
2020,国家自然科学基金面上项目, “脂质体体内性能与天然IgM吸附的相关性研究”, 参与
2019,国家自然科学基金青年项目, “精准操控脂质体蛋白冠中载脂蛋白结构和功能的新型脑靶向递药系统”, 主持
2018,中国博士后面上基金项目,“小胶质细胞上5D4-KS与BDNF-TrkB信号通路作用机制研究”,主持
课程讲授:
本科生课程:药理学;机能学实验药理部分;MBBS药理学;强基班呼吸系统课程
代表性论著:
1.Wenjing Tang#; Zui Zhang#; Cheng Li#; Yuxiu Chu; Jun Qian; Tianlei Ying*; Weiyue Lu*; Changyou Zhan*. Facile Separation of PEGylated Liposomes Enabled by Anti-PEG scFv, Nano Letters, 2021, 21( 23): 10107-10113
2.Zui Zhang#; Yuxiu Chu#; Cheng Li#; Wenjing Tang; Jun Qian; Xiaoli Wei; Weiyue Lu; Tianlei Ying*; Changyou Zhan*. Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PE Gylated nanomedicines. J Control Release, 2020, 330: 493-501
3.Yuxiu Chu#; Wenjing Tang#; Zui Zhang*; Cheng Li#; Jun Qian; Xiaoli Wei; Tianlei Ying; Weiyue Lu; Changyou Zhan*; Deciphering Protein Corona by scFv-Based Affinity Chromatography. Nano Letters, 2021, 21(5): 2124-2131
4.Zhang, Zui#; Guan, Juan; Jiang, Zhuxuan; Yang, Yang; Liu, Jican; Hua, Wei; Mao, Ying; Li, Cheng; Lu, Weiyue; Qian, Jun; Zhan, Changyou; Brain-targeted drug delivery by manipulating prote in corona functions. Nature Communications, 2019, 10: 0-3561
5.Zui Zhang#; Yoshiko Takeda-Uchimura; Tahmina Foyez; Shiori Ohtake-Niimi; Narentuya NA; Hir oyasu Akatsu; Kazuchika Nishitsuji; Makoto Michikawa; Tony Wyss-Coray; Kenji Kadomatsu; Kenji Uchimura*; Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's p athology. Proceedings of the National Academy of Sciences of the United States of America, 2017 , 114(14): 2947-2954
6.Zui Zhang#; Shiori Ohtake-Niimi; Kenji Kadomatsu; Kenji Uchimura ; Reduced molecular size and altered disaccharide composition of cerebral chondroitin sulfate upon Alzheimer's pathogenesi s in mice., Nagoya J. Med. Sci., 2016, 78: 293-301
7.Huan, Wang; Zui, Zhang; Juan, Guan; Weiyue, Lu; Changyou, Zhan ; Unraveling GLUT-mediated transcytosis pathway of glycosylated nanodisks, Asian Journal of Pharmaceutical Sciences, 2020
8.Guan, J; Shen, Q; Zhang, Z; Jiang, Z; Yang, Y; Lou, M; Qian, J; Lu, W; Zhan, C. ; Enhance d immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption, Nature Communications, 2018, 9(1): 0-2982
9.Juan Guan; Zui Zhang; Xuefeng Hu; Yang Yang; Zhilan Chai; Xiaoqin Liu; Jican Liu; Bo Gao; Weiyue Lu; Jun Qian; Changyou Zhan ; Cholera Toxin Subunit B Enabled Multifunctional Glioma-Targe ted Drug Delivery, Adv Healthc Mater, 2017, 6(23)
10.Wu, Peng-Fei; Zhang, Zui; Guan, Xin-Lei; Li, Yuan-Long; Zeng, Jian-Hua; Zhang, Juan-Juan; Long, Li-Hong; Hu, Zhuang-Li; Wang, Fang; Chen, Jian-Guo ; A specific and rapid colorimetric meth od to monitor the activity of methionine sulfoxide reductase A., Enzyme Microb Technol, 2013, 53( 6-7): 391-397
代表性专利:
1.占昌友; 张醉; 一种淀粉样蛋白β短肽介导的脑靶向递送系统及其制备方法和用途, 2019-5-17, 美国, CN201980032453.3
2.占昌友; 张醉; 一种淀粉样蛋白β短肽介导的脑靶向递送系统, 2018-6-14, 中国, CN201810626652 .4
3.占昌友; 张醉; 唐文婧; 应天雷; 李澄 ; PEG-scFv 抗体在分离游离药物和PEG 化载体药物中的用途以及分离方法, 2021-10-1, 中国, 202110515472.0