2020年代表性文章
1.Dong, P., Wang, X., Liu, L., Tang, W., Ma, L., Zeng, W., Sun, S., Zhang, L., Zhang, N., Shen, X., Janssen, H. L. A., Dong, L.*, Zhang, S.*, and Chen, S.* (2020) Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma. J Hepatol 73, 1446-1459
2.Si Zhang*, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang* & Liang Hu*. SARS-CoV- 2 binds platelet ACE2 to enhance thrombosis in COVID-19. Journal of hematology & oncology, 2020，13(1), 1-22.
3.Zhongya Sun#, Hao Zhang#, Yuanyuan Zhang#, Liping Liao#, Wen Zhou#, Fengcai Zhang, Fulin Lian, Jing Huang, Pan Xu, Rukang Zhang, Wenchao Lu, Mingrui Zhu, Hongru Tao, Feng Yang, Hong Ding, Shijie Chen, Liyan Yue, Bing Zhou, Naixia Zhang, Minjia Tan, Hualiang Jiang, Kaixian Chen, Bo Liu*, Chuanpeng Liu*, Yongjun Dang,* and Cheng Luo*. Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion. Adv Sci. 2020, 13;7(14): 2000098
4.Huo X, Ji L, Zhang Y, Lv P, Cao X, Wang Q, Yan Z, Dong S, Du D, Zhang F, Wei G, Liu Y, Wen B*. The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation. Mol Cell. 2020 Jan 16;77(2):368-383.e7.
5.Zeng H, Zhou Q, Wang Z, Zhang H, Liu Z, Huang Q, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Xu L, Dai B, Guo J, Liu L*, Zhu Y*, Xu J*.Stromal LAG-3+ cell infiltration defines poor prognosis subtype muscle-invasive bladder cancer with immunoevasive contexture. J Immunother Cancer.2020; 8(1): e000651.
6.Bing Zhao, Mengfang Wu, Zhihuang Hu, Yixin Ma, Qi Wang, Yanling Zhang, Yaran Li, Yu Min Yu, Huijie Wang*, Wei Mo*. Thrombin is a therapeutic target for non-small cell lung cancer to inhibit vasculogenic mimicry formation. Signal Transduction and Targeted Therapy. 2020; 5(1):1556-1567
7.Xiong Y, Wang Z, Zhou Q, Zeng H, Zhang H, Liu Z, Huang Q, Wang J, Chang Y, Xia Y, Wang Y, Liu L, Zhu Y, Xu L, Dai B, Bai Q*, Guo J*, Xu J*. Identification and validation of dichotomous immune subtypes based on intratumoral immune cells infiltration in clear cell renal cell carcinoma patients. J Immunother Cancer.2020; 8(1): e000447.
8.Zhou Q, Qi Y, Wang Z, Zeng H, Zhang H, Liu Z, Huang Q, Xiong Y, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Xu L, Dai B, Guo J, Zhu Y*, Zhang W*, Xu J*. CCR5 blockade inflames anti-tumor immunity in BAP1-mutant clear-cell renal cell carcinoma. J Immunother Cancer.2020; 8 (1): e000228.
9.Hu B, Wang Z, Zeng H, Qi Y, Chen Y, Wang T, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Dai B, Guo J, Xu L*, Zhang W*, Xu J*. Blockade of DC-SIGN+ tumor-associated macrophages reactivates anti-tumor immunity and improves immunotherapy in muscle-invasive bladder cancer. Cancer Res. 2020; 80(8): 1707–1719.
10.Weng ML, Chen WK, Chen XY, Lu H, Sun ZR, Yu Q, Sun PF, Xu YJ, Zhu MM, Jiang N, Zhang J, Zhang JP, Song YL, Ma D*, Zhang XP*, Miao CH*., Zhang XP*, Miao CH*. Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression. Nat Commun. 2020 Apr 20;11(1):1869. doi: 10.1038/s41467-020-15795-8.
11.Zhaomeng Cui#, Yang Liu#, Wei Wan#, Yuyan Xu, Yehui Hu, Meng Ding, Xin Dou, Ruina Wang, Hailing Li, Yongmei Meng, Wei Li, Wei Jiang, Zengxia Li, Minjia Tan, Dengke K. Ma, Yu Ding，Jun O Liu, Cheng Luo*, Biao Yu*, Qiqun Tang*, Yongjun Dang*. Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. Protein Cell. 2020 May 12.
12.Ming H, Wang Q, Zhang Y, Ji L, Cheng L, Huo X, Yan Z, Liu Z, Dang Y, Wen B*. The nuclear bodies formed by histone demethylase KDM7A. Protein Cell. 2020 Sep 16.
13.Liu X, Cao Y, Li R, Gu Y, Chen Y, Qi Y, Lv K, Wang J, Yu K, Lin C, Liu H, Zhang H, He H, Chen L, Zhang P, Shen Z, Qin J, Sun Y, Li H*, Huang H*, Zhang W*, Xu J*. Poor clinical outcomes of intratumoral dendritic cell–specific intercellular adhesion molecule 3–grabbing non-integrin–positive macrophages associated with immune evasion in gastric cancer. Eur J Cancer. 2020; 128:27-37.
14.Qingwen Zhao, Zhe Zhang, Weiqiong Rong, Weiwei Jin, Linyu Yan, Wenfang Jin,Yingjiang Xu, Xuan Cui, Qiqun Tang, Dongning Pan*. KMT5C modulates adipocyte thermogenesis by regulating Trp53 expression. Proc Natl Acad Sci USA. 2020, 117(36):22413-22422.
15.Wu H, Song SS, Yan AQ, Guo XY, Chang L, Xu L, Hu L, Kuang MZ, Liu B, He DC, Zhao R, Wang L*, Wu X*, Gu JX, Ruan YY*. RACK1 promotes the invasive activities and lymph node metastasis of cervical cancer via galectin-1. Cancer Lett. 2020 Jan;469:287-300.
16.Ziwei Liang#, Bingrui Wu#, Zhi Ji, Weitao Liu, Danfang Shi, Xiaoning Chen, Yuyanyan Wei#, Jianhai Jiang*. The binding of LDN193189 to CD133 C-terminus suppresses the tumorigenesis and immune escape of liver tumor-initiating cells. Cancer Letters, 2021, 513(10): 90-100
17.Li R, Liu H, Cao Y, Wang J, Chen Y, Qi Y, Lv K, Liu X, Yu K, Lin C, Zhang H, He H, Li H, Chen L, Shen Z, Qin J, Zhang W*, Sun Y*, Xu J*. Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis. Br J Cancer. 2020; 122(10): 1525–1534.
18.Zhou Q, Zhang H, Wang Z, Zeng H, Liu Z, Huang Q, Lin Z, Qu Y, Xiong Y, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Dai B, Guo J, Zhu Y*, Xu L*, Xu J*. Poor clinical outcomes and immunoevasive contexture in interleukin-9 abundant muscle-invasive bladder cancer. Int J Cancer. 2020;147(12):3539–3549.
19.Zeng H, Liu Z, Wang Z, Zhou Q, Qi Y, Chen Y, Chen L, Zhang P, Wang J, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Dai B, Guo J, Xu L*, Zhang W*, Xu J*. Intratumoral IL22-producing cells define immunoevasive subtype muscle-invasive bladder cancer with poor prognosis and superior nivolumab responses. Int J Cancer. 2020;146(2):542-552.
20.Yan Z, Ji L, Huo X, Wang Q, Zhang Y, Wen B*. G9a/GLP-Sensitivity of H3K9me2 Demarcates Two Types of Genomic Compartments. Genomics Proteomics Bioinformatics. 2020 Dec 4:S1672-0229(20)30132-7. （IF：7.051）
21.Li S#, Liu F#, Xu L, Li C, Yang X, Guo B, Gu J, Wang L*. Wnt/β-Catenin Signaling Axis Is Required for TFEB-Mediated Gastric Cancer Metastasis and Epithelial-Mesenchymal Transition. Mol Cancer Res. 2020 Nov;18(11):1650-1659.
22.Zhao H, Gong L, Wu S, Jing T, Xiao X, Cui Y, Xu H, Lu H, Tang Y, Zhang J, Zhou Q, Ma D*, Li X*. The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy. EBioMedicine. 2020 Jun;56:102813. doi: 10.1016/j.ebiom.2020.102813. Epub 2020 Jun 13.
23.Lu H, Zhang H, Weng ML, Zhang J, Jiang N, Cata JP, Ma D*, Chen WK, Miao CH*. Morphine promotes tumorigenesis and cetuximab resistance via EGFR signaling activation in human colorectal cancer. J Cell Physiol. 2020 Nov 13. doi: 10.1002/jcp.30161. Online ahead of print.
24.Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B*. A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165988.
25.Ji L, Huo X, Zhang Y, Yan Z, Wang Q, Wen B*. TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture. Biochim Biophys Acta Gene Regul Mech. 2020 May;1863(5):194518.
26.Xiaojing Li#, Yuanyuan Zhang#, Yuhua Fu#, Hao Zhang, Hexuan Li, Quanfu Li, Hailing Li, Renke Tan, Chenxiao Jiang, Wei Jiang, Zeng-xia Li, Cheng Luo*, Boxun Lu*, Yongjun Dang*. Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex. Acta Pharmacol Sin. 2020, accepted
27.Yaran Li, Yinong Huang, Bing Zhao, Mengfang Wu, Tianyu Li, Yanling Zhang, Di Chen, Min Yu, Wei Mo*. RGD-hirudin-based low molecular weight peptide prevents blood coagulation via subcutaneous injection. Acta Pharmacol Sin. 2020, 41(6): 753-762
28.Xu L#, Liu F#, Li C, Li S, Wu H, Guo B, Gu J*, Wang L*. Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-β1 via CLEC-2. Glycobiology. 2020 Apr 20;30(5):301-311.
29.Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Ling Dong*, Harry L. A. Janssen*, Si Zhang*. M2‐polarized tumor‐associated macrophages promote epithelial‐mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma. Journal of Cellular Biochemistry, 2020，121(4), 2828-2838.
30.Han J, Pan Y, Gu Y, Xu X, Zhao R, Sha J, Zhang R, Gu J*, Ren S*. Profiling of IgG N-glycome during mouse aging: Fucosylated diantennary glycans containing one Neu5Gc-linked LacNAc are associated with age. J Proteomics. 2020 Oct 30;229:103966.
31.Han J, Pan Y, Qin W, Gu Y, Xu X, Zhao R, Sha J, Zhang R, Gu J, Ren S*. Quantitation of sex-specific serum N-glycome changes in expression level during mouse aging based on Bionic Glycome method. Exp Gerontol. 2020 Nov;141:111098.