汤其群
汤其群，复旦大学基础医学院生物化学与分子生物学系教授、博士生导师。现任复旦大学学术委员会副主任（医学部主任），“代谢分子医学”教育部重点实验室主任，担任教育部高等学校基础医学教育指导委员会副主委。教育部“长江学者奖励计划”特聘教授，国家自然科学基金委“杰出青年基金”获得者，美国Johns Hopkins大学生物化学系兼职教授和国际著名生物化学期刊JBC副主编，美国中华医学基金会CMB杰出教授。曾任复旦大学上海医学院副院长，基础医学院院长，中国生物化学与分子生物学学会副理事长，国际著名杂志JBC副主编。
主要研究方向：
汤其群教授从事医学生化教育18年，主要从事脂肪细胞发育分化的机制和代谢性疾病关系研究，成果发表于Science，Nature metabolism，Hepatology，PNAS，Gene&Development, Cell Res, Diabetes等期刊。曾获国家科技进步二等奖、卫生部科技进步一等奖、教育部高等学校优秀科技成果奖、“霍英东优秀青年教师”一等奖（生物类）、谈家桢生命科学创新奖。担任国家卫生健康委员会“十四五”规划教材《生物化学与分子生物学》（第10版）主编；科学出版社出版的《生物化学》（英文改编版，第2版）主编；担任复旦大学出版社出版的《医学人文导论》、《代谢分子医学导论》和《医学分子遗传》主编以及复旦大学大学出版社出版的《基础医学本科核心系列教材》（一套13本）的总主编。
联系方式：
邮件：qqtang@shmu.edu.cn
电话：021-54237198
办公室：上海市徐汇区东安路131号科研2号楼A4-008
近5年代表性科研成果：
1、Liu Y, Jiang JJ, Du SY, Mu LS, Fan JJ, Hu JC, Ye Y, Ding M, Zhou WY, Yu QH, Xia YF, Xu HY, Shi YJ, Qian SW, Tang Y, Li W, Dang YJ, Dong X, Li XY, Xu CJ, Tang QQ*. Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction. Science. 2024 Jun 14;384(6701):eadk5382.
2、Meng Ding, Hong-yu Xu, Wei-yu Zhou, Yi-fan Xia, Bai-yu Li, Yi-jie Shi, Xin Dou, Qi-qi Yang, Shu-wen Qian, Yan Tang, Dong-ning Pan, Yang Liu*, Qi-qun Tang*. CLCF1 signaling restrains thermogenesis and disrupts metabolic homeostasis by inhibiting mitochondrial biogenesis in brown adipocytes. PNAS, 2023 Aug 15;120(33):e2305717120.
3、Li BY, Peng WQ, Liu Y, Guo L, Tang QQ*. HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway. Cell Rep. 2023 Jul 25;42(7):112731.
4、Tang Y, Yang LJ, Liu H, Song YJ, Yang QQ, Liu Y, Qian SW, Tang QQ*. Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis. Cell Rep. 2023 Jan 31;42(1):111948.
5、Wen-Juan Mu, Yan-Jue Song, Li-Jie Yang, Shu-Wen Qian, Qi-Qi Yang, Yang Liu, Qi-Qun Tang*, Yan Tang*. Bone morphogenetic protein 4 in perivascular adipose tissue ameliorates hypertension through regulation of angiotensinogen. Front Cardiovasc Med. 2022 Nov 14;9:1038176.
6、Guo YY, Li BY, Xiao G, Liu Y, Guo L*, Tang QQ*. Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice. Nature Metabolism. 2022 Oct;4(10):1352-1368.
7、Ding M, Ma YJ, Du RQ, Zhou WY, Dou X, Yang QQ, Tang Y, Qian SW, Liu Y, Pan DN, Tang QQ*, Liu Y*. CHCHD10 Modulates Thermogenesis of Adipocyte by Regulating Lipolysis. Diabetes. 2022 Sep 1;71(9):1862-1879.
8、Bai-Yu Li, Ying-Ying Guo, Gang Xiao, Liang Guo*, Qi-qun Tang*. SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway. Mol Metab. 2022,15;61:101500.
9、Xin Dou#, Wei-Yu Zhou#, Meng Ding, Yin-Jun Ma, Qi-Qi Yang, Shu-Wen Qian, Yan Tang, Qi-Qun Tang*, Yang Liu*. The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKα. J Biol Chem. 2021 Dec 28;298(2):101544
10、Yi-Na Wang, Yan Tang, Zhihui He, Hong Ma, Linyuan Wang, Yang Liu, Qiqi Yang, Dongning Pan, Cuiqing Zhu, Shuwen Qian*, Qi-Qun Tang*. Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue. Nature Metabolism. 2021. 3(11):1536-1551
11、Yang Liu, Xin Dou, Wei-yu Zhou, Meng Ding, Ling Liu, Ruo-qi Du, Liang Guo, Shu-wen Qian, Yan Tang, Qi-qi Yang, Dong-ning Pan, Xiao-ying Li, Yan Lu, Jin-ke Cheng, Qi-qun Tang*. Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk. Hepatology, 2021;74(4):1864-1883
12、Yuli Lin , Liuling Xiao, Qian Cai , Cuisong Zhu , Shufen Li , Bingji Li , Ting Liu , Qiongyue Zhang , Yi Wang , Yiming Li , Xing He , Dongning Pan , Qi-qun Tang , Xiaohui Wu , Weiqing Pan , Jiqiu Wang , Xi Li , Rui He. The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit. Sci Immunol, 2021 Jul 30;6(61):eabg9698.
13、Wenjuan Mu#, Shuwen Qian#, Yanjun Song, Lijie Yang, Saisai Song, Qiqi Yang, Hao Liu, Yang Liu, Dongning Pan, Yan Tang*, Qi-qun Tang*. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox biology. 2021 Jul;43:101979.
14、Shuwen Qian, Yan Tang, Qi-qun Tang*. Adipose tissue plasticity and the pleiotropic roles of BMP signaling. J Biol Chem. 2021 Apr 16:100678
15、Peng WQ, Xiao G, Li BY, Guo YY, Guo L*, Qi-qun Tang* L-Theanine Activates the Browning of White Adipose Tissue through the AMPK/α-Ketoglutarate/Prdm16 Axis and Ameliorates Diet-induced Obesity in Mice. Diabetes. 2021;70(7):1458-1472
16、Zou Y, Wang YN, Ma H, He ZH, Tang Y, Guo L, Liu Y, Ding M, Qian S*, Qi-qun Tang* SCD1 Promotes Lipid Mobilization in Subcutaneous White Adipose Tissue. J Lipid Res. 2020 Dec;61(12):1589-1604
17、Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Qi-qun Tang, Wen B (2020). A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice. Biochim Biophys Acta Mol Basis Dis. 2020 Oct 13;1867(1):165988.
18、Qingwen Zhao, Zhe Zhang, Weiqiong Rong, Weiwei Jin, Linyu Yan, Wenfang Jin, Yingjiang Xu, Xuan Cui, Qi-qun Tang, Dongning Pan.KMT5c modulates adipocyte thermogenesis by regulating Trp53 expression. Proc Natl Acad Sci USA. 2020 Sep 8;117(36):22413-22422.
19、Cui Z#, Liu Y#, Wan W#, Xu Y, Hu Y, Ding M, Dou X, Wang R, Li H, Meng Y, Li W, Jiang W, Li Z, Li Y, Tan M, Ma DK, Ding Y, Liu JO, Luo C*, Yu B*, Qi-qun Tang*, Dang Y*. Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. Protein Cell. 2021 Jun;12(6):493-501.
20、Shuwen Qian#, Jiabao Pan#, Yan Su#, Yan Tang, Yina Wang, Ying Zou, Yaxin Zhao, Hong Ma, Youyou Zhang, Yang Liu, Liang Guo, Qi-qun Tang*. BMPR2 Promotes Fatty Acid Oxidation and Protects White Adipocytes From Cell Death in Mice. Commun Biol. 2020 Apr 29;3(1):200
21、Zhao YX, Pan JB, Wang YN, Zou Y, Guo L, Qian SW, Qi-qun Tang*. Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue. Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E1158-E1171.
22、Guo YY, Li BY, Peng WQ, Guo L*, Qi-qun Tang*. Taurine-mediated browning of white adipose tissue is involved in its anti-obesity effect in mice. J Biol Chem. 2019.11;294(41):15014-15024
23、Guo L, Guo L, Guo YY, Li BY, Peng WQ, Chang XX, Gao X, Qi-qun Tang*. Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease. J Biol Chem. 2019 Aug 2;294(31):11805-11816
24、Guo L, Guo YY, Li BY, Peng WQ, Qi-qun Tang*. Histone demethylase KDM5A is transactivated by the transcription factor C/EBPβ and promotes preadipocyte differentiation by inhibiting Wnt/β-catenin signaling. J Biol Chem. 2019.14;294(24):9642-9654
25、Qian SW, Wu MY, Zhao YX, Zou Y. Wang YN, Pan JB, Tang Y, Liu Y, Huang HY, Qi-qun Tang*. BMP4 facilitates beige fat biogenesis via regulating adipose tissue macrophages. J Mol. Cell Biol, 2019. 11(1):14-25
科研项目：
1. 米色脂肪的激活及其调控，编号：81730021，
经费：292万 ，2018.01-2022.12 国家自然科学基金重点项目 项目负责人
2. 调控组织稳态和代谢平衡关键分泌因子的鉴定和机制研究，编号：2018YFA0800400，
经费：1915万元，2019.09-2024.08，国家重点研发计划，项目负责人
3. 缺氧诱导的线粒体内膜蛋白Higd1A在脂肪组织代谢稳态中的作用及其分子机制研究，编号32070760，
经费：58万元，2021.01-2024.12, 国家自然科学基金面上项目，项目负责人
4. 脂肪组织新型内分泌因子的鉴定及功能研究，编号82330023，
经费：220万元，2024.01-2028.12，国家自然科学基金重点项目，项目负责人。
专著：
“分子医学导论” 7-309-04830-X/R.928 复旦大学出版社 2006年
生物化学第7版、第8版 人民卫生出版社 2007年 编委
生物化学 科学出版社 2012年 副主编
医学分子生物学第2版 人民卫生出版社 2013 编委
《生物化学》（英文改编版，第2版）科学出版社 主编
《医学人文导论》复旦大学出版社
《代谢分子医学导论》复旦大学出版社 主编