2021年代表性文章
1. Shushu Song, Yinghong Shi, Weicheng Wu, Hao Wu, Lei Chang, Peike Peng, Lei Zhang, Jia Fan, Jianxin Gu, Yuanyuan Ruan. Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus. Gut. 2021, 70(11): 2159-2171
2. Yang Liu, Xin Dou, Wei-yu Zhou, Meng Ding, Ling Liu,Ruo-qi Du, Liang Guo, Shu-wen Qian, Yan Tang, Qi-qi Yang, Dong-ning Pan, Xiao-ying Li, Yan Lu, Jin-ke Cheng, and Qi-qun Tang. Hepatic Small Ubiquitin-Related Modifier (SUMO)–Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver–Adipose Tissue Crosstalk. Hepatology.2021, 74(4):1864-1883
3. Linyu Yan, WeiweiJin, Qingwen Zhao, Xuan Cui, Ting Shi, Yingjiang Xu,Feiyan Li, Wenfang Jin, Zhe Zhang, Zhao Zhang, Qi-qun Tang, Dongning Pan. PWWP2B fine-tunes adipose thermogenesis by stabilizing HDACs in a NuRD subcomplex. Advanced Science. 2021, 8(16): 2102060
4. S Fan#, L Yue#, W Wan#, Y Zhang#, B Zhang#, C Otomo, Q Li, T Lin, J Hu, P Xu, M Zhu, H Tao, Z Chen, L Li, H Ding, Z Yao, J Lu, Y Wen, N Zhang, M Tan, K Chen, Y Xie, T Otomo, B Zhou*, H Jiang*, Y Dang*, C Luo*. Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein. Angew Chem Int EdEngl. 2021, 60(50): 26105-26114
5. Yufu Zhou#, Shushu Song#, Mengxin Tian#, Zheng Tang#, Han Wang, Yuan Fang, Weifeng Qu, Xifei Jiang, Chenyang Tao, Run Huang, Peiyun Zhou, Shiguo Zhu, Jian Zhou, Jia Fan, Weiren Liu*, Yinghong Shi*. Cystathionine β-synthase-mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis. Journal for ImmunoTherapy of Cancer. 2021, 9(8): e003031
6. Yi-Na Wang, Yan Tang, Zhihui He, Hong Ma, Linyuan Wang, Yang Liu, Qiqi Yang, Dongning Pan, Cuiqing Zhu, Shuwen Qian*, Qi-Qun Tang*. Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue. Nature Metabolism. 2021, 3(11):1536-1551
7. Wenjuan Mu, Shuwen Qian, Yanjun Song, Lijie Yang, Saisai Song, Qiqi Yang, Hao Liu, Yang Liu, Dongning Pan, Yan Tang, Qi-Qun Tang. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox biology. 2021, 43: 101979
8. Yingjiang Xu, Ting Shi, Xuan Cui, Linyu Yan, Qi Wang, Xiaoyan Xu,Qingwen Zhao, Xiaoxuan Xu, Qi-Qun Tang, Huiru Tang, Dongning Pan. Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues. EMBO J. 2021, 40(24): e108069
9. Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen. Ruyi Xue and Si Zhang. Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2‑mediated proinflammatory response and a novel nuclear autophagy‑mediated DNA damage mechanism. J Hematol Oncol. 2021, 14(1):9
10. Peng WQ, Xiao G, Li BY, Guo YY, Guo L*, Qi-qun Tang*. L-Theanine Activates the Browning of White Adipose Tissue through the AMPK/α-Ketoglutarate/Prdm16 Axis and Ameliorates Diet-induced Obesity in Mice. Diabetes, 2021,70(7):1458-1472
11. Bing Zhao#*, Mengfang Wu#, Zhihuang Hu#, Tianfa Wang, Jinchao Yu, Yixin Ma, Qi Wang, Yanling Zhang, Di Chen, Tianyu Li, Yaran Li, Min Yu*, Huijie Wang*, Wei Mo*. A novel oncotherapy strategy, direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer. British Journal of Pharmacology. 2021, 1–18, https://doi.org/10.1111/bph.15384
12. Ziwei Liang, Bingrui Wu, Zhi Ji, Weitao Liu, Danfang Shi, Xiaoning Chen, Yuyanyan Wei#, Jianhai Jiang#. The binding of LDN193189 to CD133 C-terminus suppresses the tumorigenesis and immune escape of liver tumor-initiating cells. Cancer Letters. 2021, 513(10): 90-100
13. R Bao, Y Meng, H Zhang, C Yang, W Li, C Zhang, J Zhang, R Sun, Z Li, W Jiang, C Zhang, C Zhang*, HX Yuan*, Y Dang*. Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death Dis. 2021, 12(11):972.
14. Qingyun Yuan, Qiaoyan Liang, Zujun Sun, Xingxing Yuan, Weihua Hou, Yuxiong Wang, Huijie Wang*, Min Yu*. Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy. OncoImmunology. 2021, 10(1): 1914954
15. Shenyi Wang, Jinming Cai, Si Zhang, Mingwei Dong, Li Zhang, Yingying Xu, Bing Shen, She Chen. Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis. Cancer Science. 2021, 112(7):2625-2641.
16. Zhang M, Du S, Ou H, Cui R, Jiang N, Lin Y, Ge R, Ma D, Zhang J. Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice. J Mol Cell Biol. 2021, 13(3): 210-224
17. Chen S, Jia Z, Cai M, Ye M, Wu D, Wan T, Zhang B, Wu P, Xu Y, Guo Y, Tian C, Ma D, Ma J. SP1-Mediated Upregulation of Long Noncoding RNA ZFAS1 Involved in Non-syndromic Cleft Lip and Palate via Inactivating WNT/β-Catenin Signaling Pathway. Front Cell Dev Biol. 2021, 9:662780
18. Peiru Liu#, Jing Zhang#, Duo Du, Dandan Zhang, Zelin Jin, Wenqing Qiu, Xiushi Zhou, Shulong Dong, Mengyu Zhou, Heyu Zhao, Wei Zhang, Jiakang Ma, Shaoyang Sun, Weiguo Fu*, Yun Liu*, Lixin Wang*. Altered DNA methylation pattern reveals epigenetic regulation of Hox genes in thoracic aortic dissection and serves as a biomarker in disease diagnosis. Clinical Epigenetics. 2021, 13(1): 124
19. Gao R, Ye M, Liu B, Wei M, Ma D, Dong K. m6A Modification: A Double-Edged Sword in Tumor Development. Front Oncol. 2021, 11: 679367
20. Hong Q, Li B, Cai X, Lv Z, Cai S, Zhong Y, Wen B. Transcriptomic Analyses of the Adenoma-Carcinoma Sequence Identify Hallmarks Associated With the Onset of Colorectal Cancer. Front Oncol. 2021, 11: 704531
21. X Li#, Y Zhang#, Y Fu#, H Zhang, H Li, Q Li, H Li, R Tan, C Jiang, W Jiang, Z Li, C Luo*, B Lu*, Y Dang*. Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex. Acta Pharmacol Sin. 2021, 42(10): 1556-1566.
22. Liu G, Liu B, Liu X, Xie L, He J, Zhang J, Dong R, Ma D, Dong K, Ye M. ARID1B/SUB1-activated lncRNA HOXA-AS2 drives the malignant behaviour of hepatoblastoma through regulation of HOXA3. J Cell Mol Med.2021, 25(7): 3524-3536
23. Xiao-xiao Wang, Si Zhang, Ping-ping Dong, Yao-hua Li, Li Zhang, Song-hai Shi, Zhiqiang Yu, She Chen. MRCKβ links Dasm1 to actin rearrangements to promote dendrite development. J Biol Chem. 2021, 296: 100730.
24. Shuwen Qian, Yan Tang, Qi-qun Tang*. Adipose tissue plasticity and the pleiotropic roles of BMP signaling. J Biol Chem. 2021, 296:10067
25. M.H. Chen, L.S. Fu, F. Zhang, Y. Yang, X.Z. Wu. LncAY controls BMI1 expression and activates BMI1/Wnt/beta-catenin signaling axis in hepatocellular carcinoma. Life Sci. 2021, 280:119748
26. Xu W, Chen Z, Liu G, Dai Y, Xu X, Ma D, Liu L. Identification of a Potential PPAR-Related Multigene Signature Predicting Prognosis of Patients with Hepatocellular Carcinoma. PPAR Res. 2021:Article ID 6642939. https://doi.org/10.1155/2021/6642939
27. Cui R, Jiang N, Zhang M, Du S, Ou H, Ge R, Ma D, Zhang J. AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells. Biochim Biophys ActaMol Cell Res. 2021, 1868(1):118858
28. Ma J, Chen S, Hao L, Sheng W, Chen W, Ma X, Zhang B, Ma D, Huang G. Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation by targeting HAND2. Front Med. 2021, 15: 91-100
29. Yufeng Liu; Hanghang Cheng; Chenchen Cheng; Zhonghua Zhao; Qi Chen; Wenjiao Zeng; Cheng Huang; Wei Jiang#; Guoyuan Liu#. ZNF191 alters DNA methylation and activates PI3K-AKT pathway in hepatoma cells via transcriptional regulation of DNMT1. Cancer Medicine. 2022, 11(5): 1269-1280
30. Ye M, He J, Zhang J, Liu B, Liu X, Xie L, Wei M, Dong R, Li K, Ma D, Dong K. USP7 promotes hepatoblastoma progression through activation of PI3K/AKT signaling pathway. Cancer Biomark. 2021, 31(2): 107-117
31. Weitao Liu, Zhi Ji, BingRui Wu, Sijing Huang, Qihang Chen, Xiaoning Chen, Yuanyan Wei, Jianhai Jiang. Siglec-15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44. FEBS letters. 2021, 595(17): 2290-2302
32. Xingxing Yuan, Zujun Sun, Qingyun Yuan, Weihua Hou, Qiaoyan Liang, Yuxiong Wang, Wei Mo, Huijie Wang*, Min Yu*. Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors. Investigational New Drugs. 2021, 39(1): 34-51
33. Yannan Zhao, Dingjin Yao, Yi Li, Si Zhang, Zhonghua Tao, Li Zhang, Xichun Hu, Biyun Wang, She Chen. Loss of polarity protein Par3 is mediated by transcription factor Sp1 in breast cancer. Biochem Biophys Res Commun. 2021, 561:172-179.
34. Dong, Y., Cai, Q., Fu, L., Liu, H., Ma, M., and Wu, X. Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular Carcinoma Treatment and Prognosis. Biomed Res Int. 2021, Article ID 4873678.
35. Xu Y, Ma J, Xu G, Ma D. Recent advances in the epigenetics of bone metabolism. J Bone Miner Metab. 2021,39: 914-924.
36. Zhou J, Xiong Y, Dong X, Wang H, Qian Y, Ma D, Li X. Genome-wide methylation analysis reveals differentially methylated CpG sites and altered expression of heart development-associated genes in fetuses with cardiac defects. Exp Ther Med. 2021, 22(3): Article Number: 1032
37. Matthew R. Kudelka #, Zhonghua Li#, Tatiana A. Chernova, David F. Smith, Xuezheng Song, Richard D. Cummings, Tongzhong Ju. Cellular O-Glycome Reporter/Amplification (CORA): Analytical and Preparative Tools to Study Mucin-Type O-Glycans of Living Cells. Current Protocols. 2021, 1(6): e142
综述：
1. Zhao Zhang & Leng Han. Circular RNAs sequenced at last. Nature Biotechnology. 2021, 39, 811–812
2. N Sun#, Q Xie#, Y Dang*, Y Wang*. Agonist lock touched and untouched retinoic acid receptor-related orphan receptor-γt (RORγt) inverse agonists: classification based on the molecular mechanisms of action. J Med Chem. 2021, 64(15):10519-10536.
3. 穆文娟; 杨丽洁; 宋赛赛; 汤妍; 不同脂肪组织与动脉粥样硬化关系的研究进展. 生命科学 2021, 33(02): 166-175