张朋
张朋，青年副研究员
教育及工作经历：
2019.10-至今 复旦大学基础医学院生物化学与分子生物学系，青年副研究员
2016.09-2019.09 威斯康星医学院病理学系，博士后研究员
2012.09-2016.08 郑州大学内科学专业，博士研究生
2009.09-2012.08 新乡医学院病理学与病理生理学专业，硕士研究生
2006.09-2009.08 新乡医学院临床医学专业，本科生
联系方式：
Email：peng_zhang@fudan.edu.cn
电话：021-5423-7291
地址：上海市徐汇区东安路131号东1号楼343室
研究方向：
1、肿瘤发病机制研究：采用分子遗传学、全基因组关联研究、高通量测序等方法，研究前列腺癌和食管癌等的易感及发生发展机制。
2、肿瘤转化医学研究：采用生物化学与分子生物学、功能基因组学、生物信息学等方法，研究前列腺癌和食管癌等的遗传风险位点与驱动基因的生物学机制及临床意义，寻找潜在的分子标志物和临床精准治疗靶点。
人才项目：
2019，复旦大学引进人才
科研奖项：
2014，河南省科学技术进步一等奖，河南省教育厅，第14完成人
科研项目：
2020-2024，NIH/NCI，R01，Functional characterization of prostate cancer risk loci by high throughput sequencing，在研，参加
2015-2018，国家自然科学基金委员会，面上项目，同卵双胞胎食管癌患者全基因组外显子测序和变异基因功能研究，已结题，参加
讲授课程：
本科生课程：生物化学实验、MBBS-The Experiments in Biochemistry
代表性论著：
1. Yang Chen#, Peng Zhang#, Jinling Liao#, Jiwen Cheng, Qin Zhang, Tianyu Li, Haiying Zhang, Yonghua Jiang, Fangxing Zhang, Yanyu Zeng, Linjian Mo, Haibiao Yan, Deyun Liu, Qinyun Zhang, Chunlin Zou*, Gong-Hong Wei*, Zengnan Mo*. Single-cell transcriptomics reveals cell type diversity of human prostate. Journal of Genetics and Genomics. 2022 Apr 5; S1673-8527(22)00090-X. PMID: 35395421.
2. Peng Zhang#, Lori S Tillmans#, Stephen N Thibodeau, Liang Wang*. Single-Nucleotide Polymorphisms Sequencing Identifies Candidate Functional Variants at Prostate Cancer Risk Loci. Genes (Basel). 2019 Jul 18;10(7):547. PMID: 31323811; PMCID: PMC6678189.
3. Peng Zhang#, Ji-Han Xia#, Jing Zhu, Ping Gao, Yi-Jun Tian, Meijun Du, Yong-Chen Guo, Sufyan Suleman, Qin Zhang, Manish Kohli, Lori S Tillmans, Stephen N Thibodeau, Amy J French, James R Cerhan, Li-Dong Wang*, Gong-Hong Wei*, Liang Wang*. High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. Nature Communications. 2018 May 22;9(1):2022. PMID: 29789573; PMCID: PMC5964124.
4. Josephine My Ko#, Peng Zhang#, Simon Law, Yanhui Fan, You-Qiang Song, Xue Ke Zhao, Elibe H W Wong, Sa Tang, Xin Song, Maria Li Lung*, Li Dong Wang*. Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma. Oncology Reports. 2014 Aug;32(2):860-870. PMID: 24890309.
5. Xiaoming Dong#, Qin Zhang#, Jinglan Hao#, Qianwen Xie, Binbing Xu, Peng Zhang, Haicheng Lu, Qilai Huang, Tielin Yang, Gong-Hong Wei*, Rong Na*, Ping Gao*. Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. Frontiers in Oncology. 2021 Nov 10; 11:754206. PMID: 34858826; PMCID: PMC8631195.
6. Ping Gao#, Ji-Han Xia#, Csilla Sipeky, Xiao-Ming Dong, Qin Zhang, Yuehong Yang, Peng Zhang, Sara Pereira Cruz, Kai Zhang, Jing Zhu, Hang-Mao Lee, Sufyan Suleman, Nikolaos Giannareas, Song Liu, PRACTICAL Consortium; Teuvo L J Tammela, Anssi Auvinen, Xiaoyue Wang, Qilai Huang, Liguo Wang, Aki Manninen, Markku H Vaarala, Liang Wang, Johanna Schleutker, Gong-Hong Wei*. Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus. Cell. 2018 Jul 26;174(3):576-589.e18. PMID: 30033361; PMCID: PMC6091222.
7. Yuan Wang#, Rachel Lieberman#, Jing Pan, Qi Zhang, Meijun Du, Peng Zhang, Marja Nevalainen, Manish Kohli, Niraj K Shenoy, Hui Meng, Ming You, Liang Wang*. miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. Molecular Cancer. 2016 Nov 10;15(1):70. PMID: 27832783; PMCID: PMC5105253.
8. Chen Wu#, Zhaoming Wang#, Xin Song#, Xiao-Shan Feng#, Christian C Abnet#, Jie He#, Nan Hu#, Xian-Bo Zuo#, Wen Tan#, Qimin Zhan, ......, Peng Zhang, ......, Alisa M Goldstein, Dongxin Lin*, Philip R Taylor*, Li-Dong Wang*, Stephen J Chanock. Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Nature Genetics. 2014 Sep;46(9):1001-1006. PMID: 25129146; PMCID: PMC4212832.
9. Christian C Abnet#*, Zhaoming Wang#, Xin Song#, Nan Hu#, Fu-You Zhou#, Neal D Freedman#, Xue-Min Li#, Kai Yu, ......, Peng Zhang, ......, Liang Wang, Song-Liang Qiu*, Alisa M Goldstein*, Zhi-Qing Yuan*, Stephen J Chanock*, Xue-Jun Zhang*, Philip R Taylor*, Li-Dong Wang*. Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. Human Molecular Genetics. 2012 May 1;21(9):2132-2141. PMID: 22323360; PMCID: PMC3315211.
10. Li-Dong Wang*, Fu-You Zhou, Xue-Min Li, ......, Peng Zhang, ......, Liang Wang, Song-Liang Qiu, Zhi-Ming Cai, Xue-Jun Zhang. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nature Genetics. 2010 Sep;42(9):759-763. PMID: 20729853.