张朝

张朝，复旦大学基础医学院生物化学与分子生物学系青年研究员，博士生导师。2016年获得复旦大学生物信息学博士学位，2016-2020年间在美国德克萨斯大学休斯顿健康科学中心从事博士后研究。2021年入职复旦大学，在生物化学与分子生物学系和代谢分子医学教育部重点实验室开展基因调控与复杂疾病方向的研究。

主要研究方向：

1. 计算生物学与多组学：开发计算生物学方法鉴别疾病中转录及转录后调控、翻译及翻译后调控中多维度多层次的功能分子。

2. 基因调控与复杂疾病：识别疾病中关键的调控元件并探索其机制和潜在临床价值。

联系方式：

Email：ZhaoZhang@fudan.edu.cn

电话：021-54237896

地址：上海市徐汇区东安路131号科研2号楼A4-015

代表性科研成果（*通讯作者，#第一作者）：

1. Zhang, Zhao, Luo, Mei, Li, Qiang, Liu, Yuan, Lussier, Charles, Zhang, Jian, Ye, Youqiong, Guo, An-Yuan, Han, Leng. Genetic, Pharmacogenomic and Immune landscapes of enhancer RNAs across human cancers. Cancer Research. 2022.82(5): 785–790

2. Jin, Weiwei, Jiang, Guanghui, Yang, Yanbo, Yang, Jianye, Yang, Wenqian, Wang, Dongyang, Niu, Xiaohui, Zhong, Rong, Zhang, Zhao, Gong, Jing. Animal-eRNAdb: a comprehensive animal enhancer RNA database. Nucleic acids research. 2022.50(D1): D46–D53

3. Zhang, Zhao, Hong, Wei, Ruan, Hang, Jing, Ying, Li, Shengli, Liu Yaoming, Wang, Jun, Li,Wenbo, Diao, Lixia, Han, Leng. HeRA: an atlas of enhancer RNAs across human tissues. Nucleic acids research. 2021.49(D1):D932–D938

4. Zhao Zhang*, Jian Zhang, Lixia Diao & Leng Han*. Small non-coding RNAs in human cancer: function, clinical utility, and characterization. Oncogene. 2021, 40:1570–1577

5. Zhao Zhang, Leng Han*. Circular RNAs sequenced at last. Nature Biotechnology, 2021, 39: 811–812

6. Zhang, Zhao, Jing, Ji, Ye, Youqiong, Chen, Zhiao, Jing, Ying, Li, Shengli, Hong, Wei, Ruan, Hang, Liu, Yaoming, Hu, Qingsong, Wang, Jun, Li, Wenbo, Lin, Chunru, Diao, Lixia, Zhou, Yubin, Han, Leng. Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors. Genome Medicine. 2020, 12:Article number:101, https://doi.org/10.1186/s13073-020-00795-6

7. Youqiong Ye#, Zhao Zhang#, Yaoming Liu, Lixia Diao* & Leng Han*. A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine. Trends in Genetics. 2020, 36(5):p318–336

8. Zhang, Zhao, Lee, Joo-Hyung, Ruan, Hang, Ye, Youqiong, Krakowiak, Joanna, Hu, Qingsong, Xiang, Yu, Gong, Jing, Zhou, Bingying, Wang, Li, Lin, Chunru, Diao, Lixia, Mills, Gordon B., Li, Wenbo, Han, Leng. Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer. Nature Communications. 2019, 10:4562. https://doi.org/10.1038/s41467-019-12543-5.

9. Zhao Zhang#, Youqiong Ye#, Jing Gong, Hang Ruan, Chun-Jie Liu, Yu Xiang, Chunyan Cai, An-Yuan Guo, Jiqiang Ling, Lixia Diao*, John N Weinstein* & Leng Han*. Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers. Communications Biology. 2018, 1:234. https://doi.org/10.1038/s42003-018-0239-8.

科研项目：

1. 上海市浦江人才计划，30万，（2021-2023），主持。

主讲课程：

1. 本科生课程：生物化学，生物化学II

2. 研究生课程：生物大分子