宋淑淑
宋淑淑,青年副研究员。
教育及工作经历:
2009/9-2013/6 山东大学理学学士
2013/9-2018/6 复旦大学生物化学与分子生物学专业博士
2018/9-2021/8 复旦大学附属中山医院肝癌研究所博士后
2021/9-至今 复旦大学基础医学院青年副研究员
联系方式:
邮箱:shushusong@fudan.edu.cn
电话:021-54237694
地址:上海市东安路131号科研2号楼A4-028
主要研究方向:
1. O-糖基化在肿瘤及炎症相关疾病中的生物学作用
2. 肿瘤免疫微环境的调控
在研科研项目:
浆膜蛋白RTN3通过PD-L1调控肝癌免疫逃逸的功能机制研究(82103535),30万元,2022.01-2024.12,国家自然科学基金青年项目,项目负责人。
近年来科研成果:
1. Song S, Shi Y, Wu W, Wu H, Chang L, Peng P, Zhang L, Fan J, Gu J, Ruan Y*. Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus. Gut. 2021 Nov;70(11):2159-2171.
2. Zhou Y#, Song S#, Tian M#, Tang Z#, Wang H, Fang Y, Qu W, Jiang X, Tao C, Huang R, Zhou P, Zhu S, Zhou J, Fan J, Liu W*, Shi Y*. Cystathionine β-synthase-mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltra-tion and induces apoptosis to inhibit HCC carcinogenesis. J Immunother Cancer. 2021 Aug;9(8):e003031.
3. Song S#*, Liu B#, Zeng X, Wu Y, Chen H, Wu H, Gu J, Gao X*, Ruan Y*, Wang H*. Reticulon 2 promotes gastric cancer metastasis via activating endoplasmic reticulum Ca2+ efflux-mediated ERK signalling. Cell Death Dis. 2022 Apr 15;13(4):349.
4. Song S#, Peng P#, Tang Z#, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, Zhang M, Zhang J, Wu H, Li C, Wang X, Wang H*, Ruan Y*, Gu J. Decreased expression of STING predicts poor prognosis in patients with gastric cancer. Sci Rep. 2017 Feb 8;7:39858.
5. Peng P#, Min L#, Song S#, Zhao J, Li L, Yang C, Shao M, Zhang M, Wu H, Zhang J, Li C, Wang X, Wang H*, Qin J*, Ruan Y*, Gu J. Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy. Int J Mol Sci. 2016 Sep 27;17(10):1612.
6. Wu H, Song S, Yan A, Guo X, Chang L, Xu L, Hu L, Kuang M, Liu B, He D, Zhao R, Wang L*, Wu X*, Gu J, Ruan Y*.RACK1 promotes the invasive activities and lymph node metastasis of cervical cancer via galectin-1.Cancer Lett. 2020 Jan 28;469:287-300.
7. Duan F, Wu H, Jia D, Wu W, Ren S, Wang L, Song S, Guo X, Liu F*, Ruan Y*, Gu J.O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis.J Hepatol. 2018 Jun;68(6):1191-1202.
8. 专利:顾建新,阮元元,贾冬威,宋淑淑,邵苗苗,李莉莉. O-GlcNAc糖基化修饰在防治肝纤维化中的应用,2019.09.2,中国,ZL201510979220.8