卫功宏
卫功宏，博导，复旦大学特聘教授。2006年博士毕业于北京协和医学院；2006年底于芬兰国立公共卫生研究所、国家卫生和福利研究所及赫尔辛基大学医学院从事博士后研究；2011-2019年任职芬兰奥卢大学医学院，独立PI，历任青年研究员、副教授、教授；2014-2019任芬兰科学院研究员；2019年起加盟复旦大学基础医学院。
E-mail: gonghong_wei@fudan.edu.cn
研究方向主要集中于恶性肿瘤易感、发生发展和转移的生物学机制，以及潜在的临床转化应用。主要运用生化与分子生物学、（表观）遗传与功能基因组学、高通量DNA测序和生物信息学等方法，以及基于实验大数据的整合基因组和系统生物学研究策略，解析恶性泌尿肿瘤、乳腺癌、肝癌或其它复杂疾病风险位点和驱动基因的功能。近年来以通讯或资深作者在Cell、Nature Genetics、Nature Communications、Clinical Cancer Research等期刊发表系列研究论文；研究工作曾受到知名国际杂志Nature Genetics, Cancer Discovery, Nature Reviews Urology等和Faculty of 1000的关注和点评，以及 Science Daily，赫尔辛基日报等媒体的报道。多次受邀为Nature Genetics, Nature Communications，Genome Biology，Genome Research，Cell Research，Theranostics，Science Bulletin等四十多种学术杂志审稿。曾分别获得奥卢大学生物中心2014，2016和2018年度发现奖，以及2014和2018年度芬兰生物医学和临床科学领域最佳论文奖（Medix Prize 2015；2019）；指导博士生曾获2016年度芬兰奥卢大学医学部最佳博士论文奖和2019年度国家自费留学奖学金，目前已培养的1名博士后和1名博士生分别任国内重点大学博导、教授。
代表性论文(#并列第一作者；*通讯作者)
1. Gao P#, Xia JH#, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP, Zhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S; PRACTICAL Consortium, Tammela TLJ, Auvinen A, Wang X, Huang Q, Wang L, Manninen A, Vaarala MH, Wang L, Schleutker J, Wei GH*. Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus. Cell. 2018. 174:576-589.
Previewed in Bulger M. Changing the Guard at a Prostate Cancer SNP. Cell. 174:501-502, 2018
Highlighted in Bradley C. Mechanistic insights into a non-coding risk SNP. Nature Reviews Urology 15:655, 2018
Invited author's views: Xia JH & Wei GH. Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness. Molecular & Cellular Oncology. 5(6):e1516451. 2018
2. Huang Q#, Whitington T#, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J*, Wei GH*. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. Nature Genetics. 2014. 46:126-135.
Previewed in HOXB13, RFX6 and prostate cancer risk. Nature Genetics. 46:94-95, 2014
Highlighted in Prostate cancer: HOXB13 and a SNP collaborate to increase risk. Nature Reviews Urology. 11:64, 2014
Research Watch A Prostate Cancer–Associated SNP Increases HOXB13 Binding. Cancer Discovery 4:268, 2014
Recommended by Faculty of 1000: ★★ Very Good, good for teaching, new finding. In F1000Prime, 27 Jan 2014; DOI: 10.3410/f.718228195.793490008
News in JNCI: Journal of the National Cancer Institute, 2014
Eturauhassyöpään johtava geenimuutos löytyi Oulussa. HELSINGIN SANOMAT Jan 10 2014
3. Whitington T#, Gao P#, Song W, Ross-Adams H, Lamb AD, Yang Y, Svezia I, Klevebring D, Mills IG, Karlsson R, Halim S, Dunning MJ, Egevad L, Warren AY, Neal DE, Grönberg H, Lindberg J, Wei GH (joint supervision), Wiklund F. Gene regulatory mechanisms underpinning prostate cancer susceptibility. Nature Genetics. 2016. 48:387-397.
Research Watch Prostate Cancer Risk Loci Are Associated with Gene Regulatory Mechanisms. Cancer Discovery 6:OF13, 2016
4. Zhang P#, Xia J#, Zhu J, Gao P, Tian YJ, Du M, Guo CY, Suleman S, Zhang Q, Kohli M, Tillmans L, Thibodeau SN, French AJ, Cerhan JR, Wang LD*, Wei GH*, Wang L*. High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. Nature Communications. 2018. 9, 2022.
5. Sipeky C#, Gao P#, Zhang Q, Wang L, Ettala O, Talala K, Tammela TL, Auvinen A, Wiklund F, Wei GH*, Schleutker J*. Synergistic interaction of HOXB13 and CIP2A predispose to aggressive prostate cancer. Clinical Cancer Research. 2018. 15;24(24):6265-6276.
6. Wei GH, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-Wide Analysis of ETS Family DNA-Binding in vitro and in vivo. EMBO J. 2010. 29:2147-2160.
7. Wei GH, Liu DP, Liang CC. Chromatin domain boundaries: insulators and beyond. Cell Research. 2005. 15:292-300.
8. Wei GH, Liu DP, Liang CC. Charting gene regulatory networks: strategies, challenges and perspectives. Biochem J. 2004. 381(Pt 1):1-12.