刘浥

刘浥，博士，研究员，博士生导师

教育背景

2004年    美国加州大学河滨分校，生物医学系，博士

1997年    复旦大学，遗传系，学士

工作经历

2017-至今    复旦大学基础医学院 研究员

2010-2017   中科院上海生科院营养科学研究所 研究员

2005-2010   美国索科尔生物研究所（The Salk Institute） 博士后

2004-2005   美国加州大学河滨分校 博士后

人才项目

2010年    入选中国科学院“百人计划”

2012年    获得基金委优青资助

研究方向

生物钟和糖代谢调控机制主要以生物钟和糖代谢调控网络的互作机制为研究方向，探索生物钟维持糖代谢稳态的分子调控机制，及其在2型糖尿病发生发展中的病理机理。

代表性论文

1、Chen Y, Wang J, Wang Y, Wang P, Zhou Z, Wu R, Xu Q, You H, Liu Y, Wang L,Zhou L, Wu Y, Hu L*, Liu H*, Liu Y*. A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex. Nature Communications, 2022, 13(1):246

2、Wu R., Dang F., Li P., Wang P., Xu Q., Liu Z., Li Y., Wu Y., Chen Y., Liu Y*., The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex. (2019) Cell Metabolism, 29:653-677

3、Dang, F., Sun, X., Ma, X., Wu, R., Zhang, D., Chen, Y., Xu, Q., Wu, Y., Liu Y*. Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock. (2016) Nature Communications. 7:12696 Doi:10.1038/ncomms12696.

4、Ma X, Zhou Z, Chen Y, Wu Y, Liu Y*., (2016) RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice. Diabetologia. 59(2):354-62.

5、Sun, X., Dang, F., Zhang, D., Yuan, Y., Zhang, C., Wu, Y., Wang, Y., Liu, Y*., (2015) Glucagon-CREB/CRTC2 Signaling Cascade Regulates Hepatic BMAL1 Protein. J Biol Chem. 290(4):2189-97.

发表论文

1、Chen Y, Wang J, Wang Y, Wang P, Zhou Z, Wu R, Xu Q, You H, Liu Y, Wang L, Zhou L, Wu Y, Hu L, Liu H, Liu Y*. A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex. Nature Communications, 2022, 13(1):246.

2、Wu R., Dang F., Li P., Wang P., Xu Q., Liu Z., Li Y., Wu Y., Chen Y., Liu Y*., The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex. Cell Metabolism, 2019, 29:653-677

3、Dang F., Wu R., Wang P., Wu Y., Azam S., Liu Y*., Fasting and Feeding Signals Control the Oscillatory Expression of Angptl8 to Modulate Lipid Metabolism. (2016) Scientific Report. 6:36926; doi: 10.1038/srep36926

4、Dang, F., Sun, X., Ma, X., Wu, R., Zhang, D., Chen, Y., Xu, Q., Wu, Y., Liu Y*. Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock. (2016) Nature Communications. 7:12696 Doi:10.1038/ncomms12696.

5、Ma X, Zhou Z, Chen Y, Wu Y, Liu Y*., (2016) RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice. Diabetologia. 59(2):354-62.

6、Sun, X., Dang, F., Zhang, D., Yuan, Y., Zhang, C., Wu, Y., Wang, Y., Liu, Y*., (2015) Glucagon-CREB/CRTC2 Signaling Cascade Regulates Hepatic BMAL1 Protein. J Biol Chem. 290(4):2189-97.

7、Zhang, E.E*., Liu, Y*., Dentin, R., Pongsawakul, P.Y., Liu, A.C., Hirota, T., Nusinow, D.A., Sun, X., Landais, S., Kodama, Y., Brenner, D.A., Montminy, M., Kay, S.A. (2010) Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nature Medicine 16:1152-1156. (* co-first authors)

8、Wang, Y., Inoue, H., Ravnskjaer, K., Viste, K., Miller, N., Liu, Y*., Hedrick, S., Vera, L., Montminy, M. (2010) Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. 107(7):3087-92.

9、Liu, Y*., Dentin, R.*, Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D.J., Cole, P., Yates, J.R. 3rd., Olefsky, J., Guarente, L., Montminy, M. (2008) A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456, 269-273. (* co-first authors)

10、Dentin, R.*, Liu, Y*., Koo, S., Hedrick, S., Vargas, T., Heredia, J., Yates, J.R. 3rd., Montminy, M. (2007) Insulin Modulates Gluconeogenesis via Inhibition of the Coactivator TORC2. Nature 449:366-369. (* co-first authors)

11、Ravnskjaer, K., Kester, H., Liu, Y., Zhang, X., Lee, D., Yates, J.R. 3rd., Montminy, M. (2007) Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J. 26:2880-2889.

12、Liu, Y., Montminy, M. (2006) CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5. Cell Metab. 3:387-388.

13、Fang, X., Hu, S., Xu, B., Snyder, G.D., Harmon, S., Yao, J., Liu, Y., Sangras, B., Falck, J.R., Weintraub, N.L., Spector, A.A. (2006) 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. Am J Physiol Heart Circ Physiol. 290:H55-63.

14、Liu, Y*., Zhang, Y*., Schmelzer, K., Lee, T.S., Fang, X., Zhu, Y., Spector, A.A., Gill, S., Morisseau, C., Hammock, B.D., Shyy, J.Y. (2005) The anti-inflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 102:16747-16752. (*co-first authors)

15、Fang, X., Hu, S., Watanabe, T., Weintraub, N.L., Snyder, G.D., Yao, J., Liu, Y., Shyy, J.Y., Hammock, B.D., Spector, A.A. (2005) Activation of Peroxisome Proliferator-activated Receptor (alpha) by Substituted Urea-derived Soluble Epoxide Hydrolase Inhibitors. J. Pharmacol. Exp. Ther. 314:260-270.

16、Yeh, M., Cole, A.L., Choi, J., Liu, Y., Tulchinsky, D., Qiao, J.H., Fishbein, M.C., Dooley, A.N., Hovnanian, T., Mouilleseaux, K., Vora, D.K., Yang, W.P., Gargalovic, P., Kirchgessner, T., Shyy, J.Y., Berliner, J.A. Role of sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. (2004) Circ Res. 95:780-788.

17、Zeng, L., Liao, H., Liu, Y., Lee, T.S., Zhu, M., Wang, X., Stemerman, M.B., Zhu, Y., Shyy, J.Y. Sterol-responsive element-binding protein (SREBP) 2 down-regulate ATP-binding cassette transporter A 1 in vascular endothelial cell: a 4 novel role of SREBP in regulating cholesterol metabolism. (2004) J. Biol. Chem., 279:48801-48807.

18、Liu, Y., Zhu, Y., Rannou, F., Lee, T.S., Formentin, K., Zeng, L., Yuan, X., Wang, N., Chien, S., Forman, B.M., Shyy, J.Y. Laminar Flow Activates Peroxisome Proliferator-Activator Receptor γ in Vascular Endothelial Cells. (2004) Circulation, 110:1128-1133.

19、Lin, T., Zeng, L., Liu, Y., DeFea, K., Schwartz, M.A., Chien, S., Shyy, J.Y. The Rho-ROCK-LIMK-Cofilin Pathway Regulates Shear Stress Activation of Sterol Regulatory Element Binding Proteins. (2003) Circ Res., 92:1296-1304.

20、Liu, Y*., Chen, B.P*., Lu, M., Zhu, Y., Stemerman, M.B., Chien, S., Shyy, J.Y. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. (2002) Arterioscler. Thromb. Vasc. Biol., 22: 76-81. (* co-first authors)

21、Yang, L., Kuo, C.B., Liu, Y., Coss, D., Xu, X., Chen, C., Oster-Granite, M.L., Walker, A.M. Administration of unmodified prolactin (U-PRL) and a molecular mimic of phosphorylated prolactin (PP-PRL) during rat pregnancy provides evidence that the U-PRL: PP-PRL ratio is crucial to the normal development of pup tissues. (2001) J. Endocrinol., 168: 227-238.