2025年代表性文章

1. Zhang J*, Xiang WQ, Ma D*. Individualized gene editing: A leap forward in treating rare genetic disorders. The Innovation. 2025;6(11):101116.

2. Chenyang Zhang, Yan-Yan Chen, Shuyu Chen, Yunzhe Wang, Yifan Yuan, Xiwen Yang, Wei Hu, Bo Chen, Zengxin Qi, Jason T Huse, Yun Liu, Bo Wen, Xiuping Liu*, Leng Han*, Yuxiang Wang*, Zhao Zhang*.Characterization of an enhancer RNA signature reveals treatment strategies for improving immunotherapy efficacy in cancer. Cancer Research. 2025; 85 (8): 1530–1543.

3. Zhao Q, Cui X, Zhu Q, Li F, Bao R, Shi T, Liu H, Lv W, Xu Y, Gao Y, Tang QQ, Zhang M, Pan D*. Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis. Nat Commun. 2025 Feb 10, 16(1): 1483.

4. Dandan Dong#, Zixian Wang#, Mengqi Liu, Qin Zhang, Wenjie Xu, Yu Wei, Jing Zhu, Xiayun Yang, Qixiang Zhang, Yao Zhu, Liang Wang*, Peng Zhang*, Gong-Hong Wei*. Combined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus. Nat Commun. 2025 Oct 8;16(1):8950. PMID: 41062477.

5. Yi Gao, Shiyin Fan, Xue Sun, Jiaxi Li, Yue Dai, Hongchen Li, Haijie Ma*, Yanping Xu*, Lei Lv*. Oncometabolite fumarate facilitates PD-L1 expression and immune evasion in clear cell renal cell carcinoma. Cell Death & Disease. 2025 Jun 3;16(1):432.

6. Yue Dai#, Hongchen Li#, Shiyin Fan, Kai Wang, Ziyi Cui, Xinyu Zhao, Xue Sun, Mingen Lin, Jiaxi Li, Yi Gao, Ziyin Tian, Hui Yang*, Bingbing Zha*, Lei Lv*, Yanping Xu*. Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma. Cell Death & Disease. 2025 Feb 6;16(1):71.

7. Yuan H, Jiang M, Xu X, Zhu J, Dong S, Meng W, Zhang D, Ma J, Lin Y, Chen Z, Sun S, Qiu W, Liu Y.* Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines. Genes & Diseases. (2025) 12(5):101603.

8. Li F, Huang HS, Zhao Q, Zhang W, Shi T, Lv W, Zhu Q, Liu H, Huang H, Tang QQ, Gao Y, Peng T, Pan D*. Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction. EMBO J. 2025 Sep 15; 44 (18): 5005 -5036.

9. Yunzhe Wang, James Wengler, Yuzhu Fang, Joseph Zhou, Hang Ruan, Zhao Zhang*, Leng Han*. Characterization of tumor antigens from multi-omics data: computational approaches and resources. Genomics, Proteomics & Bioinformatics. 2025; 23(3), qzaf001.

10. Xinyang Li, Yue Hua, Jiahui Wang, Mengxiao Wu, Yu Pan, Jiyong Wang, and Xiaoqing Gan*. B4GALT1 and Wntless collaborate to block LRP5/6 translocation from Golgi to cell surface. Journal of Cell Biology. 2025, 224 (12):1-19.

11. Tianfa Wang, Zhiyuan Shen, Liu Yang, Xiaohan Zhang, Min Yu*, Sanjian Yu*, Bing Zhao*, The coagulation and tumor system are directly linked through the proteolysis and activation of epidermal growth factor receptor by thrombin, Oncogene. 2025 May;44(17):1153-1166.

12. Wenjie Xu#, Qixiang Zhang#, Lijuan Qiao#, Zixi Wang, Tian Wang, Dandan Dong, Qin Zhang, Liang Wang*, Gong-Hong Wei*, Peng Zhang*. IP-SNPs-seq links noncoding risk alleles to lineage transcription factor programs in prostate cancer. Cellular and Molecular Life Sciences. 2025 Dec 8;82(1):438.

13. Yajun Hu, Zhiyuan Shen, Liu Yang, Yanling Zhan, Tianfa Wang, Xiaohan Zhang, Sanjian Yu*, Min Yu*, Bing Zhao*. ISM1 regulates white adipose tissue remodelling by dampeningadipocyte differentiation and enhancing inflammation, Diabetes Obesity &Metabolism. 2025 Jun;27(6):3050-3060.

14. Wei Zhang, Yan Zhang, Liping Han, Tao Bo, Zhiyong Qi, Haoxuan Zhong, Huajie Xu, Liang Hu*, She Chen*, Si Zhang*. Double-stranded DNA enhances platelet activation, thrombosis, and myocardial injury via cyclic GMP-AMP synthase. Cardiovascular Research. 2025, 121(2):353-366.

15. Lixiao Zhou^#, Liyang Yu^#, Shushu Song^#, Yong Wang^#, Qiang Zhu^#, Meng Li, Yutong Sha, Liang Xu, Xin Shu, Qingqing Liao, Ting Wu, Bing Yang, Siyuan Chai, Bingyi Lin, Liming Wu, Ruhong Zhou, Xiaotao Duan, Chenggang Zhu, Yuanyuan Ruan*, Wen Yi*. Mina53 catalyzes arginine demethylation of p53 to promote tumor growth. Cell Rep. 2025 Feb;44(2):115242.

16. Bo Liu, Yingying Wu, Anyi Xiang, Yiyi Yu, Shushu Song, Ying Zhang*, Jianxin Gu, Haojie Lu*, Ping Xu*, Fenglin Liu*, Yuanyuan Ruan*.The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level. Cell Rep. 2025 Sep;44(9):116249.

17. Zhao Huijuan, Fan Jiteng, Han Jing, Qin Wenjun, Sha Jicheng, Zhang Weilong, Gu Yong, Ma Xiaonan, Gu Jianxin*, Ren Shifang*. Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics. Engineering. 2025. Epub, https://doi.org/10.1016/j.eng.2025.07.042.

18. Weilong Zhang, Liqi Xie, Huijuan Zhao, Xiaonan Ma, Shifang Ren*. High-throughput glycosylation screening method for biologics development using MALDI-TOF-MS. Commun Chem. 2025 Oct 2;8(1):291.

19. Zhixue Chen, Lin Xu, Yejv Yuan, Si Zhang*, Ruyi Xue *. Metabolic crosstalk between platelets and cancer: Mechanisms, functions, and therapeutic potential. Seminars in Cancer Biology. 2025 Feb 13;110:65-82.

20. Lin, X. H. ^#, Y. Y. Xu^#, E. C. Bai^#, Y. R. Deng, W. Zhang, R. Y. Xue, S. Zhang, L. Zhang, W. Q. Tang*, L. Dong*, and S. Chen*. 6-Aminonicotinamide, a G6pd Inhibitor, Mitigates Caps1 Reduction Mediated Hcc Metastasis Via Erk and Gsk3β Signals. Neoplasia 2025,70:101239.

21. Jiang, S. Y. ^#, L. Y. Jiang^#, Y. Y. Xu, Y. J. Ma, Y. R. Deng, C. Jiao, M. Yin, C. Qin, J. L. Li, L. Zhang, and S. Chen*. Usp5 Deubiquitinates and Stabilizes Impdh2, to Promote Hepatocellular Carcinoma Progression. Oncogene 2025,44(24):1936.

22. Wenjing Ma^#, Junyuan Luo^#, Huan Liu^#, Qi Du, Tianhui Hao, Yinyu Jiang, Zhengwei Huang, Lefu Lan*, Zhonghua Li*, and Tiehai Li*, Chemoenzymatic Synthesis of Highly O-Glycosylated MUC7 Glycopeptides for Probing Inhibitory Activity against Pseudomonas aeruginosa Biofilm Formation. Angew Chem Int Ed Engl. 2025, May; 64(20):e202424312.

23. Zhonghua Li*^#, Yuxiao Zhang^#, Yi Lasanajak, Qing Zhang, Lauren Byrd-Leotis, David A. Steinhauer, Haojie Lu, and Xuezheng Song*, A Simple One-Step Deuterated Peracetylation-MALDI-MS/MS (OSDPM) Strategy for Structural Sequencing of Glycosaminoglycan Oligosaccharides. Anal Chem. 2025 Aug; 97(31):16778-16787.

24. Liu Z, Zhang L, Jin K, Zeng H, Su X, Ding Y, Sun J, Wu Y, Liu H, Zhu Y, Xu L, Zhang W*, Wang Z*, Chang Y*, Xu J*. ARID1A loss plus CD8⁺ T cell infiltration associate with favorable clinical outcomes in urothelial carcinoma. Clin Cancer Res. 2025;31(20):4311-4322.

25. Jin K, Ding Y, Xu J, Liu Z, Zeng H, Su X, Zhang L, Sun J, Wu Y, Liu H, Chang Y, Zhu Y, Wang Z*, Xu L*, Zhang W*, Xu J*. Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression. J Immunother Cancer. 2025;13(1):e010964.

26. Zhang L, Liu Z, Jin K, Ding Y, Sun J, Wu Y, Su X, Zeng H, Liu H, Chang Y, Zhu Y, Wang Z*, Xu L*, Zhang W*, Xu J*. Natural killer cell infiltration elicits gender-dependent dichotomous clinical outcomes in urothelial carcinoma. Cancer. 2025; 131(24):e70196.

27. Sun M, Gu Y, Wang J, Zhang Z, Ling Z, Shao F, Lin C, He H, Li R*, Liu H*, Xu J*. Smad4 loss identifies aggressive subtype with immunotherapy and anti-HER-2 treatment resistance in gastric cancer. Br J Cancer. 2025; 132(12):1148-1157.

28. Jiang W, Liu L, Xu Z, Qiu Y, Zhang B, Cheng J, Luo J, Qu Y*, Guo J*, Xu J*.  SPP1+ Tumor-associated Macrophages Drive Immunotherapy Resistance via CD8+ T Cell Dysfunction in Clear Cell Renal Cell Carcinoma. Cancer Immunol Res. 2025; 3(10):1533-1546.